Imatinib and Methotrexate interaction
Imatinib and Methotrexate: the Imatinib prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Imatinib (Gleevec) label · effective 2026-07-13
Gleevec may delay the clearance of methotrexate when methotrexate is used at high doses (> 500 mg/m 2 ).
Interactions With Methotrexate Gleevec may delay the clearance of methotrexate and result in sustained methotrexate concentrations when methotrexate is used at high doses (> 500 mg/m 2 ).
Refer to the prescribing information for methotrexate injection for recommendations on management of methotrexate concentrations.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.