Isosorbide dinitrate and Nitroglycerin interaction
Isosorbide dinitrate and Nitroglycerin: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Nitroglycerin (NITROGLYCERIN LINGUAL) label · effective 2025-12-17
Hypersensitivity to Nitroglycerin Lingual Spray or to other nitrates or nitrites or any excipient.
Hypersensitivity Nitroglycerin Lingual Spray is contraindicated in patients who are allergic to nitroglycerin, other nitrates or nitrites or any excipient.
From the Isosorbide dinitrate label · effective 2020-03-02
Drug Interactions The vasodilating effects of isosorbide dinitrate may be additive with those of other vasodilators.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.