Ketamine and Methylphenidate interaction
Ketamine and Methylphenidate: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Methylphenidate (Methylphenidate Extended-Release) label · effective 2026-06-16
Intervention Avoid use of methylphenidate extended-release orally disintegrating tablets in patients being treated with anesthetics on the day of surgery.
Halogenated Anesthetics Clinical Impact Concomitant use of halogenated anesthetics and methylphenidate extended-release orally disintegrating tablets may increase the risk of sudden blood pressure and heart rate increase during surgery.
From the Ketamine (Ketalar) label · effective 2026-03-27
Sympathomimetics and Vasopressin : Sympathomimetics and vasopressin may enhance the sympathomimetic effects of ketamine [see Drug Interactions ( 7.2 )] .
Closely monitor vital signs when KETALAR and sympathomimetics or vasopressin are co-administered and consider dose adjustment individualized to the patient’s clinical situation.
Sympathomimetics and Vasopressin : Closely monitor vital signs when co-administered with KETALAR.
Sympathomimetics and Vasopressin Sympathomimetics and vasopressin may enhance the sympathomimetic effects of ketamine.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.