Methylphenidate interactions
Methylphenidate (Ritalin, Concerta, Jornay), a CNS stimulant has 155 documented interactions across the FDA labels and fact sheets we index: 30 major, 113 moderate, 12 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This drug page is a starting point, not a verdict for your situation.
Major interactions (30)
Do Not Exceed Recommended Dose Fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs in patients with asthma. (Albuterol label, Warnings and precautions)
Hypersensitivity reactions such as angioedema and anaphylactic reactions have been reported in patients treated with other amphetamine products [see Adverse Reactions ( 6.2 )] . taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive… (Amphetamine and dextroamphetamine label, Contraindications)
Clinically significant cardiovascular effects and fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs. (Budesonide and formoterol label, Warnings and precautions)
Intervention Concomitant use of methylphenidate extended-release orally disintegrating tablets with a gastric pH modulator (i.e., a H2-blocker or a proton pump inhibitor) is not recommended. (Methylphenidate label, Drug interactions)
Intervention Concomitant use of methylphenidate extended-release orally disintegrating tablets with a gastric pH modulator (i.e., a H2-blocker or a proton pump inhibitor) is not recommended. (Methylphenidate label, Drug interactions)
• Hypersensitivity to methylphenidate or other components of Focalin XR. (Dexmethylphenidate label, Contraindications)
Avoid concomitant use of other drugs that are also associated with similar cardiac effects (e.g., amphetamines, other sympathomimetic agents, atropine, amoxapine, scopolamine, antihistamines, other anticholinergic agents, amitriptyline, desipramine, other tricyclic antidepressants). (Dronabinol label, Warnings and precautions)
Intervention Concomitant use of methylphenidate extended-release orally disintegrating tablets with a gastric pH modulator (i.e., a H2-blocker or a proton pump inhibitor) is not recommended. (Methylphenidate label, Drug interactions)
Intervention Concomitant use of methylphenidate extended-release orally disintegrating tablets with a gastric pH modulator (i.e., a H2-blocker or a proton pump inhibitor) is not recommended. (Methylphenidate label, Drug interactions)
Clinically significant cardiovascular effects and fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs. (Fluticasone and salmeterol label, Warnings and precautions)
Clinically significant cardiovascular effects and fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs. (Formoterol label, Warnings and precautions)
Concomitant treatment with monoamine oxidase inhibitors (MAOIs), and also within a minimum of 14 days following discontinuation of treatment with a monoamine oxidase inhibitor because of the risk of hypertensive crisis [see Drug Interactions (7.1) ]. (Methylphenidate label, Contraindications)
Intervention Avoid use of methylphenidate extended-release orally disintegrating tablets in patients being treated with anesthetics on the day of surgery. (Methylphenidate label, Drug interactions)
Intervention Concomitant use of methylphenidate extended-release orally disintegrating tablets with a gastric pH modulator (i.e., a H2-blocker or a proton pump inhibitor) is not recommended. (Methylphenidate label, Drug interactions)
Do Not Exceed Recommended Dose Fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs in patients with asthma. (Levalbuterol label, Warnings and precautions)
Concomitant treatment with monoamine oxidase inhibitors (MAOIs), and also within a minimum of 14 days following discontinuation of treatment with a monoamine oxidase inhibitor because of the risk of hypertensive crisis [see Drug Interactions (7.1) ]. (Methylphenidate label, Contraindications)
• Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects [see Adverse Reactions (6) , Drug Interactions (7.7) , and Overdosage (10) ] . (Liothyronine label, Boxed warning)
Intervention Concomitant use of methylphenidate extended-release orally disintegrating tablets with a gastric pH modulator (i.e., a H2-blocker or a proton pump inhibitor) is not recommended. (Methylphenidate label, Drug interactions)
Intervention Concomitant use of methylphenidate extended-release orally disintegrating tablets with a gastric pH modulator (i.e., a H2-blocker or a proton pump inhibitor) is not recommended. (Methylphenidate label, Drug interactions)
Intervention Concomitant use of methylphenidate extended-release orally disintegrating tablets with a gastric pH modulator (i.e., a H2-blocker or a proton pump inhibitor) is not recommended. (Methylphenidate label, Drug interactions)
Concomitant treatment with monoamine oxidase inhibitors (MAOIs), and also within a minimum of 14 days following discontinuation of treatment with a monoamine oxidase inhibitor because of the risk of hypertensive crisis [see Drug Interactions (7.1) ]. (Methylphenidate label, Contraindications)
Intervention Avoid use of methylphenidate extended-release orally disintegrating tablets in patients being treated with anesthetics on the day of surgery. (Methylphenidate label, Drug interactions)
Intervention Concomitant use of methylphenidate extended-release orally disintegrating tablets with a gastric pH modulator (i.e., a H2-blocker or a proton pump inhibitor) is not recommended. (Methylphenidate label, Drug interactions)
Concomitant treatment with monoamine oxidase inhibitors (MAOIs), and also within a minimum of 14 days following discontinuation of treatment with a monoamine oxidase inhibitor because of the risk of hypertensive crisis [see Drug Interactions (7.1) ]. (Methylphenidate label, Contraindications)
Clinically significant cardiovascular effects and fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs. (Salmeterol label, Warnings and precautions)
Concomitant treatment with monoamine oxidase inhibitors (MAOIs), and also within a minimum of 14 days following discontinuation of treatment with a monoamine oxidase inhibitor because of the risk of hypertensive crisis [see Drug Interactions (7.1) ]. (Methylphenidate label, Contraindications)
Many patients who received Xyrem during clinical trials in narcolepsy were receiving central nervous system stimulants [see Clinical Trials ( 14 )]. (Sodium oxybate label, Boxed warning)
Hypersensitivity Terbutaline sulfate is contraindicated in patients known to be hypersensitive to sympathomimetic amines or any component of this drug product. (Terbutaline label, Contraindications)
Concomitant treatment with monoamine oxidase inhibitors (MAOIs), and also within a minimum of 14 days following discontinuation of treatment with a monoamine oxidase inhibitor because of the risk of hypertensive crisis [see Drug Interactions (7.1) ]. (Methylphenidate label, Contraindications)
Clinically significant cardiovascular effects and fatalities have been reported in association with excessive use of inhaled sympathomimetic drugs. (Umeclidinium and vilanterol label, Warnings and precautions)
Moderate interactions (113)
Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of their effect. (Acetazolamide label, Drug interactions)
Sympathomimetics, Methylxanthines, Steroids In clinical studies, concurrent administration of aclidinium bromide and other drugs commonly used in the treatment of COPD including sympathomimetics (short-acting beta 2 agonists), methylxanthines, and oral and inhaled steroids showed no increases in adverse drug reactions. (Aclidinium label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Alprazolam label, Warnings and precautions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
When amitriptyline is given with anticholinergic agents or sympathomimetic drugs, including epinephrine combined with local anesthetics, close supervision and careful adjustment of dosages are required. (Amitriptyline label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Amlodipine and benazeprildihydropyridine calcium channel blockerModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Azilsartanangiotensin II receptor blocker (ARB)Moderate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Bisoprolol and hydrochlorothiazidebeta blockerModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
…medications that lower the seizure threshold (e.g., other bupropion products, antipsychotics, tricyclic antidepressants, theophylline, and systemic corticosteroids), metabolic disorders (e.g., hypoglycemia, hyponatremia, severe hepatic impairment, and hypoxia), or use of illicit drugs (e.g., cocaine) or abuse or misuse of prescription drugs such as CNS stimulants. (Bupropion label, Warnings and precautions)
- Candesartanangiotensin II receptor blocker (ARB)Moderate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- CaptoprilACE inhibitorModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- ChlordiazepoxidebenzodiazepineModerate
Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Chlordiazepoxide label, Warnings)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (Citalopram label, Warnings and precautions)
- ClobazambenzodiazepineModerate
Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Clobazam label, Warnings and precautions)
Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Clonazepam label, Warnings)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- DesvenlafaxineSNRIModerate
The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (Desvenlafaxine label, Warnings and precautions)
Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Diazepam label, Warnings)
…drugs including dicyclomine hydrochloride: amantadine, antiarrhythmic agents of Class I (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and other drugs having anticholinergic activity. (Dicyclomine label, Drug interactions)
Sympathomimetics Epinephrine Can increase the risk of cardiac arrhythmias. (Digoxin label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (Duloxetine label, Warnings and precautions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- EpinephrinesympathomimeticModerate
• Drugs that potentiate the effects of epinephrine include sympathomimetics, beta blockers, tricyclic antidepressants, MAO inhibitors, COMT inhibitors, clonidine, doxapram, oxytocin, levothyroxine sodium, and certain antihistamines. (Epinephrine label, Drug interactions)
- Eplerenonealdosterone antagonistModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, meperidine, methadone, lithium, tramadol, tryptophan, buspirone, amphetamines, and St. (Escitalopram label, Warnings and precautions)
- Esmololbeta blockerModerate
• Sympathomimetic drugs: Dose adjustment needed ( 7 ) (Esmolol label, Drug interactions)
- Ethacrynic acidloop diureticModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Felodipinedihydropyridine calcium channel blockerModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, meperidine, methadone, buspirone, amphetamines, and St. (Fluoxetine label, Warnings and precautions)
- FluvoxamineSSRIModerate
The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, meperidine, methadone, lithium, tramadol, tryptophan, buspirone, amphetamines, and St. (Fluvoxamine label, Warnings and precautions)
- FosinoprilACE inhibitorModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
…somatropin, protease inhibitors, atypical antipsychotic medications (e.g., olanzapine and clozapine), barbiturates, diazoxide, laxatives, rifampin, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics (e.g., epinephrine, albuterol, terbutaline), and isoniazid. (Glimepiride label, Drug interactions)
…olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), thyroid hormones, phenytoin, nicotinic acid, and calcium channel blocking drugs. (Glipizide label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Indapamidethiazide diureticModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
…Insulin Aspart Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. (Insulin aspart label, Drug interactions)
- Insulin degludecinsulinModerate
…Insulin Degludec Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. (Insulin degludec label, Drug interactions)
- Insulin detemirinsulinModerate
…Effect of LEVEMIR Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. (Insulin detemir label, Drug interactions)
…Glargine-yfgn Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. (Insulin glargine label, Drug interactions)
…Effect of LYUMJEV Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. (Insulin lispro label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Isosorbide dinitrate and hydralazinenitrateModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Isradipinedihydropyridine calcium channel blockerModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- LevomilnacipranSNRIModerate
The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (Levomilnacipran label, Warnings and precautions)
Sympathomimetics Concurrent use may of sympathomimetics and levothyroxine may increase the effects of sympathomimetics or thyroid hormone. (Levothyroxine label, Drug interactions)
Additionally, in studies of another stimulant, there was slowing of the increase in height [see Adverse Reactions (6.1) ] . (Lisdexamfetamine label, Warnings and precautions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Lisinopril and hydrochlorothiazideACE inhibitorModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Lofexidinealpha-adrenergic agonistModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Lorazepam label, Warnings and precautions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- MethyldopaantihypertensiveModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- MinoxidilvasodilatorModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, and St. (Mirtazapine label, Warnings and precautions)
- MoexiprilACE inhibitorModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Nadololbeta blockerModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Naltrexone and bupropionopioid antagonistModerate
…tumor or infection, or metabolic disorders (e.g., hypoglycemia, hyponatremia, severe hepatic impairment, and hypoxia) excessive use of alcohol or sedatives, addiction to cocaine or stimulants, or withdrawal from sedatives patients with diabetes treated with insulin and/or oral diabetic medications (sulfonylureas and meglitinides) that may cause hypoglycemia concomitant… (Naltrexone and bupropion label, Warnings and precautions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Nicardipinedihydropyridine calcium channel blockerModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Nisoldipinedihydropyridine calcium channel blockerModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Close supervision and careful adjustment of the dosage are required when Pamelor is used with other anticholinergic drugs and sympathomimetic drugs. (Nortriptyline label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
The risk is increased with concomitant use of other serotonergic agents (including triptans, tricyclic antidepressants, fentanyl, tramadol, meperidine, methadone, lithium, tryptophan, buspirone, amphetamines, and St. (Paroxetine label, Warnings and precautions)
- PerindoprilACE inhibitorModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Risk of Abuse and Dependence Phentermine is related chemically and pharmacologically to amphetamine (d- and d l l-amphetamine) and other related stimulant drugs that have been extensively abused. (Phentermine label, Warnings and precautions)
- PhenylephrinedecongestantModerate
Pressor Effect with Concomitant Oxytocic Drugs Oxytocic drugs potentiate the increasing blood pressure effect of sympathomimetic pressor amines including BIORPHEN [see Drug Interactions (7.1) ] , with the potential for hemorrhagic stroke. (Phenylephrine label, Warnings and precautions)
…sulfaphenazole, sulfadiazine, sulfamethoxazole-trimethoprim Other Acute alcohol intake, amiodarone, chloramphenicol, chlordiazepoxide, disulfiram, estrogen, fluvastatin, isoniazid, methylphenidate, phenothiazines, salicylates, ticlopidine, tolbutamide, trazodone, warfarin Drugs that may decrease phenytoin serum levels Antacids Antacids may affect absorption of… (Phenytoin label, Drug interactions)
- Pindololbeta blockerModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Risperidone Clinical Impact Combined use of methylphenidate with risperidone when there is a change, whether an increase or decrease, in dosage of either or both medications, may increase the risk of extrapyramidal symptoms (EPS). (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, and St. (Sertraline label, Warnings and precautions)
Beta-2-Receptor Stimulants Beta-agonists such as albuterol, terbutaline and isoproterenol may have to be administered in increased dosages when used concomitantly with sotalol. (Sotalol label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Spironolactone and hydrochlorothiazidealdosterone antagonistModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Temazepam label, Warnings)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Concomitant Respiratory Medications SPIRIVA RESPIMAT has been used concomitantly with short-acting and long-acting sympathomimetic (beta-agonists) bronchodilators, methylxanthines, oral and inhaled steroids, antihistamines, mucolytics, leukotriene modifiers, cromones, and anti-IgE treatment without increases in adverse reactions. (Tiotropium label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- TrandolaprilACE inhibitorModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Triamterenepotassium-sparing diureticModerate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- TriazolambenzodiazepineModerate
Prescribe the lowest effective dosage; avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (e.g., opioid analgesics, stimulants); and advise patients on the proper disposal of unused drug. (Triazolam label, Warnings and precautions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
- Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, meperidine, methadone, busipirone, amphetamines, and St. (Venlafaxine label, Warnings and precautions)
Antihypertensive Drugs: Monitor blood pressure. (Methylphenidate label, Drug interactions)
The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, meperidine, methadone, lithium, tramadol, tryptophan, buspirone, amphetamines, and St. (Vilazodone label, Warnings and precautions)
The risk is increased with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, meperidine, methadone, buspirone, amphetamines, and St. (Vortioxetine label, Warnings and precautions)
The risk is increased with concomitant use of other serotonergic drugs (including selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, tricyclic antidepressants, fentanyl, tramadol, meperidine, methadone, lithium, tryptophan, buspirone, amphetamines, and St. (Ziprasidone label, Warnings and precautions)
Minor mentions (12)
- AcarboseantidiabeticMinor
These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. (Acarbose label, Drug interactions)
- Empagliflozin and metforminSGLT2 inhibitorMinor
These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (Empagliflozin and metformin label, Drug interactions)
These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (Glyburide label, Drug interactions)
- Glyburide and metforminsulfonylureaMinor
Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (Glyburide and metformin label, Drug interactions)
- Insulin regular (human)insulinMinor
Atypical Antipsychotics (e.g., olanzapine and clozapine), Corticosteroids, Danazol, Diuretics, Estrogens, Glucagon, Isoniazid, Niacin, Oral Contraceptives, Phenothiazines, Progestogens (e.g., in oral contraceptives), Protease inhibitors, Somatropin, Sympathomimetic Agents (e.g., albuterol, epinephrine, terbutaline) and Thyroid Hormones. (Insulin regular (human) label, Drug interactions)
ATROVENT HFA has been used concomitantly with other drugs, including sympathomimetic bronchodilators, methylxanthines, oral and inhaled steroids commonly used in the treatment of COPD. (Ipratropium label, Drug interactions)
Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (Metformin label, Drug interactions)
- Pioglitazone and metforminthiazolidinedioneMinor
These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (Pioglitazone and metformin label, Drug interactions)
- Ramelteonsedative-hypnoticMinor
In addition, in vitro data indicate that ramelteon does not cause false-positive results for benzodiazepines, opiates, barbiturates, cocaine, cannabinoids, or amphetamines in two standard urine drug screening methods in vitro . (Ramelteon label, Warnings and precautions)
- RepaglinidemeglitinideMinor
…antipsychotics (e.g., olanzapine and clozapine), calcium channel antagonists, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones. (Repaglinide label, Drug interactions)
- Sitagliptin and metforminDPP-4 inhibitorMinor
Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (Sitagliptin and metformin label, Drug interactions)
- TiagabineanticonvulsantMinor
In most cases, patients were using concomitant medications (antidepressants, antipsychotics, stimulants, narcotics) that are thought to lower the seizure threshold. (Tiagabine label, Warnings)
Check Methylphenidate against everything you take. Add your full list; every pair is checked at once.
Open in the checkerNot medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.