Lamotrigine and Levonorgestrel and ethinyl estradiol interaction
Lamotrigine and Levonorgestrel and ethinyl estradiol: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Lamotrigine (SUBVENITE) label · effective 2026-06-04
Decrease in levonorgestrel component by 19%.
Concomitant Use with Estrogen-Containing Products, Including Oral Contraceptives Some estrogen-containing oral contraceptives have been shown to decrease serum concentrations of lamotrigine [see Clinical Pharmacology ( 12.3 )] .
Dosage adjustments will be necessary in most patients who start or stop estrogen-containing oral contraceptives while taking SUBVENITE [see Dosage and Administration ( 2.1 )] .
Estrogen-containing oral contraceptives decrease lamotrigine concentrations by approximately 50%.
Specific dosing guidance for these drugs is provided in the Dosage and Administration section, and, for women taking estrogen-containing products, including oral contraceptives, in the Warnings and Precautions section [see Dosage and Administration ( 2.1 ), Warnings and Precautions ( 5.9 )] .
From the Levonorgestrel and ethinyl estradiol (Tyblume) label · effective 2026-08-27
Table 4 Significant Drug Interaction Information for Drugs Co-Administered with CHCs Lamotrigine Clinical effect Concomitant use of CHCs with lamotrigine may significantly decrease systemic exposure of lamotrigine due to induction of lamotrigine glucuronidation [see Clinical Pharmacology (12.3) ].
Decreased systemic exposure of lamotrigine may reduce seizure control.
Consult the approved product labeling for lamotrigine.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.