Methotrexate and Theophylline interaction
Methotrexate and Theophylline: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Methotrexate (Xatmep) label · effective 2026-05-28
Effect of XATMEP on Other Drugs Theophylline Methotrexate may decrease the clearance of theophylline.
Monitor theophylline levels when coadministered with XATMEP.
From the Theophylline label · effective 2026-01-29
Methotrexate (MTX) Decreases theophylline clearance.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.