Methylphenidate and Propofol interaction
Methylphenidate and Propofol: the Methylphenidate prescribing label flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Methylphenidate (Methylphenidate Extended-Release) label · effective 2026-06-16
Intervention Avoid use of methylphenidate extended-release orally disintegrating tablets in patients being treated with anesthetics on the day of surgery.
Halogenated Anesthetics Clinical Impact Concomitant use of halogenated anesthetics and methylphenidate extended-release orally disintegrating tablets may increase the risk of sudden blood pressure and heart rate increase during surgery.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.