Metoprolol and Venlafaxine interaction
Metoprolol and Venlafaxine: the Venlafaxine prescribing label describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Venlafaxine (Venlafaxine Hydrochloride) label · effective 2025-01-31
Caution should be exercised with co-administration of venlafaxine and metoprolol.
Metoprolol - Concomitant administration of venlafaxine (50 mg every 8 hours for 5 days) and metoprolol (100 mg every 24 hours for 5 days) to 18 healthy male subjects in a pharmacokinetic interaction study for both drugs resulted in an increase of plasma concentrations of metoprolol by approximately 30-40% without altering the plasma concentrations of its active…
Metoprolol: Possibly reduced blood-pressure lowering effect despite increased metoprolol plasma levels.
Venlafaxine appeared to reduce the blood pressure lowering effect of metoprolol in this study.
Metoprolol did not alter the pharmacokinetic profile of venlafaxine or its active metabolite, O-desmethylvenlafaxine.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.