التداخل بين ميتوبرولول وفينلافاكسين

Caution should be exercised with co-administration of venlafaxine and metoprolol.

Metoprolol - Concomitant administration of venlafaxine (50 mg every 8 hours for 5 days) and metoprolol (100 mg every 24 hours for 5 days) to 18 healthy male subjects in a pharmacokinetic interaction study for both drugs resulted in an increase of plasma concentrations of metoprolol by approximately 30-40% without altering the plasma concentrations of its active…

Metoprolol: Possibly reduced blood-pressure lowering effect despite increased metoprolol plasma levels.

Venlafaxine appeared to reduce the blood pressure lowering effect of metoprolol in this study.

Metoprolol did not alter the pharmacokinetic profile of venlafaxine or its active metabolite, O-desmethylvenlafaxine.