Naproxen and esomeprazole and Rifampin interaction
Naproxen and esomeprazole and Rifampin: the Naproxen and esomeprazole prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Naproxen and esomeprazole (Naproxen and esomeprazole magnesium) label · effective 2026-05-27
John’s Wort or Rifampin : Avoid concomitant use.
John’s Wort, rifampin : Avoid concomitant use with naproxen and esomeprazole magnesium delayed-release tablets [see Warnings and Precautions ( 5.25 ) ].
John’s Wort or rifampin) can substantially decrease esomeprazole concentrations.
Table 4: Clinically Significant Interactions with Esomeprazole Magnesium - Affecting Co-Administered Drugs CYP2C19 or CYP3A4 Inducers Clinical Impact : Decreased exposure of esomeprazole when used concomitantly with strong inducers [see Clinical Pharmacology (12.3) ].
John’s Wort or rifampin [see Drug Interactions (7) ].
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.