Nitroprusside and Sodium thiosulfate interaction
Nitroprusside and Sodium thiosulfate: the Nitroprusside prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Nitroprusside (Sodium Nitroprusside) label · effective 2026-06-24
(When sodium thiosulfate is given, as described under DOSAGE AND ADMINISTRATION, the body's capacity for CN - elimination is greatly increased.) Methemoglobin normally present in the body can buffer a certain amount of CN - , but the capacity of this system is exhausted by the CN - produced from about 500 mcg/kg of sodium nitroprusside.
In some of these cases, infusion of sodium thiosulfate caused dramatic clinical improvement, supporting the diagnosis of cyanide toxicity.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.