التداخل بين نيتروبروسيد وثيوسلفات الصوديوم

(When sodium thiosulfate is given, as described under DOSAGE AND ADMINISTRATION, the body's capacity for CN - elimination is greatly increased.) Methemoglobin normally present in the body can buffer a certain amount of CN - , but the capacity of this system is exhausted by the CN - produced from about 500 mcg/kg of sodium nitroprusside.

In some of these cases, infusion of sodium thiosulfate caused dramatic clinical improvement, supporting the diagnosis of cyanide toxicity.