Omeprazole and sodium bicarbonate and Rifampin interaction
Omeprazole and sodium bicarbonate and Rifampin: both prescribing labels flag this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Omeprazole and sodium bicarbonate (Konvomep) label · effective 2025-12-16
John’s Wort or Rifampin : Avoid concomitant use of KONVOMEP.
John’s Wort, rifampin : Avoid concomitant use with KONVOMEP [see Warnings and Precautions ( 5.11 )] .
John’s wort or rifampin) can substantially decrease omeprazole concentrations [see Drug Interactions ( 7 )] .
Table 6: Clinically Relevant Interactions Affecting Omeprazole when Co-Administered with Other Drugs CYP2C19 or CYP3A4 Inducers Clinical Impact: Decreased exposure of omeprazole when used concomitantly with strong inducers [see Clinical Pharmacology ( 12.3 )] .
From the Rifampin label · effective 2026-05-05
Quinine Prevention or Management : Avoid concomitant use Decrease AUC by 75%-85% Telithromycin Decrease AUC by 86% Theophylline Decrease exposure by 20%-40% Effect of Other Drugs on Rifampin Concomitant antacid administration may reduce the absorption of rifampin.
Daily doses of rifampin should be given at least 1 hour before the ingestion of antacids.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.