Orlistat and Vitamin D interaction
Orlistat and Vitamin D: the Orlistat prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Orlistat label · effective 2026-01-09
The effect of ORLISTAT on the absorption of supplemental vitamin D, vitamin A, and nutritionally-derived vitamin K is not known at this time [see Clinical Pharmacology (12.3) , and Warnings and Precautions (5.1) ] .
In addition, the levels of vitamin D and beta-carotene may be low in obese patients compared with non-obese subjects.
Curated guidance for Vitamin D
These reduce absorption of vitamin D (a fat-soluble vitamin); take vitamin D several hours apart.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.