Interaction Checker

Vitamin D interactions

Some medicines lower vitamin D levels; with thiazide diuretics, vitamin D can raise blood calcium too high.

Vitamin D has 37 documented interactions across the FDA labels and fact sheets we index: 1 major, 15 moderate, 21 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This vitamin and mineral page is a starting point, not a verdict for your situation.

Major interactions (1)

  • Calcitriolvitamin D analogMajor

    CONTRAINDICATIONS Calcitriol should not be given to patients with hypercalcemia or evidence of vitamin D toxicity. (Calcitriol label, Contraindications)

Moderate interactions (15)

  • Bisoprolol and hydrochlorothiazidebeta blockerModerate

    Thiazide diuretics reduce calcium excretion; combined with vitamin D and calcium supplements this can lead to hypercalcemia, especially in older adults. (NIH Office of Dietary Supplements, Vitamin D)

  • Chlorthalidonethiazide diureticModerate

    Thiazide diuretics reduce calcium excretion; combined with vitamin D and calcium supplements this can lead to hypercalcemia, especially in older adults. (NIH Office of Dietary Supplements, Vitamin D)

  • DenosumabModerate

    Monitor calcium levels during therapy, especially in the first weeks of initiating therapy, and adequately supplement all patients with calcium and vitamin D. (Denosumab label, Warnings and precautions)

  • Hydrochlorothiazidethiazide diureticModerate

    Thiazide diuretics reduce calcium excretion; combined with vitamin D and calcium supplements this can lead to hypercalcemia, especially in older adults. (NIH Office of Dietary Supplements, Vitamin D)

  • IbandronatebisphosphonateModerate

    Instruct patients to take supplemental calcium and vitamin D if their dietary intake is inadequate (see Dosage and Administration [2.3] ) . (Ibandronate label, Warnings and precautions)

  • Indapamidethiazide diureticModerate

    Thiazide diuretics reduce calcium excretion; combined with vitamin D and calcium supplements this can lead to hypercalcemia, especially in older adults. (NIH Office of Dietary Supplements, Vitamin D)

  • Lisinopril and hydrochlorothiazideACE inhibitorModerate

    Thiazide diuretics reduce calcium excretion; combined with vitamin D and calcium supplements this can lead to hypercalcemia, especially in older adults. (NIH Office of Dietary Supplements, Vitamin D)

  • Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Thiazide diuretics reduce calcium excretion; combined with vitamin D and calcium supplements this can lead to hypercalcemia, especially in older adults. (NIH Office of Dietary Supplements, Vitamin D)

  • Metolazonethiazide diureticModerate

    Thiazide diuretics reduce calcium excretion; combined with vitamin D and calcium supplements this can lead to hypercalcemia, especially in older adults. (NIH Office of Dietary Supplements, Vitamin D)

  • OrlistatModerate

    The effect of ORLISTAT on the absorption of supplemental vitamin D, vitamin A, and nutritionally-derived vitamin K is not known at this time [see Clinical Pharmacology (12.3) , and Warnings and Precautions (5.1) ] . (Orlistat label, Drug interactions)

  • PhenytoinanticonvulsantModerate

    Effects on Vitamin D and Bone The chronic use of phenytoin in patients with epilepsy has been associated with decreased bone mineral density (osteopenia, osteoporosis, and osteomalacia) and bone fractures. (Phenytoin label, Warnings and precautions)

  • RisedronatebisphosphonateModerate

    Calcium Supplements/Antacids When Risedronate sodium delayed-release was administered following breakfast, the co-administration of a tablet containing 600 mg of elemental calcium and 400 international units vitamin D reduced risedronate bioavailability by approximately 38% [ see Clinical Pharmacology (12.3) ] . (Risedronate label, Drug interactions)

  • Spironolactone and hydrochlorothiazidealdosterone antagonistModerate

    Thiazide diuretics reduce calcium excretion; combined with vitamin D and calcium supplements this can lead to hypercalcemia, especially in older adults. (NIH Office of Dietary Supplements, Vitamin D)

  • Triamterene and hydrochlorothiazidepotassium-sparing diureticModerate

    Thiazide diuretics reduce calcium excretion; combined with vitamin D and calcium supplements this can lead to hypercalcemia, especially in older adults. (NIH Office of Dietary Supplements, Vitamin D)

  • Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Moderate

    Thiazide diuretics reduce calcium excretion; combined with vitamin D and calcium supplements this can lead to hypercalcemia, especially in older adults. (NIH Office of Dietary Supplements, Vitamin D)

Minor mentions (21)

  • AlendronatebisphosphonateMinor

    Other disorders affecting mineral metabolism (such as vitamin D deficiency) should also be effectively treated. (Alendronate label, Warnings and precautions)

  • BeclomethasonecorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • BetamethasonecorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • BudesonidecorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • Budesonide and formoterolcorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • Cholestyraminebile acid sequestrantMinor

    These reduce absorption of vitamin D (a fat-soluble vitamin); take vitamin D several hours apart. (NIH Office of Dietary Supplements, Vitamin D)

  • ClobetasolcorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • Colesevelambile acid sequestrantMinor

    These reduce absorption of vitamin D (a fat-soluble vitamin); take vitamin D several hours apart. (NIH Office of Dietary Supplements, Vitamin D)

  • DesonidecorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • DexamethasonecorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • FludrocortisonecorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • FluocinonidecorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • FluticasonecorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • Fluticasone and salmeterolcorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • HalobetasolcorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • HydrocortisonecorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • MethylprednisolonecorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • MometasonecorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • PrednisolonecorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • PrednisonecorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

  • TriamcinolonecorticosteroidMinor

    Corticosteroids such as prednisone reduce calcium absorption and impair vitamin D metabolism, contributing to bone loss. (NIH Office of Dietary Supplements, Vitamin D)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.