Pralatrexate and Probenecid interaction
Pralatrexate and Probenecid: the Pralatrexate prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Pralatrexate label · effective 2022-11-15
Avoid coadministration with probenecid or nonsteroidal anti-inflammatory drugs.
Effects of Other Drugs on Pralatrexate Injection Coadministration of Pralatrexate injection with probenecid increased pralatrexate plasma concentrations [see Clinical Pharmacology ( 12.3 )] , which may increase the risk of adverse reactions.
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Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.