Pramipexole and Rasagiline interaction
Pramipexole and Rasagiline: the Rasagiline prescribing label describes an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Rasagiline label · effective 2020-06-30
For this reason, prescribers should monitor patients for drowsiness or sleepiness, because some of the events occur well after initiation of treatment with dopaminergic medication.
Dyskinesia When used as an adjunct to levodopa, rasagiline may cause dyskinesia or potentiate dopaminergic side effects and exacerbate preexisting dyskinesia.
Patients with a major psychotic disorder should ordinarily not be treated with rasagiline because of the risk of exacerbating the psychosis with an increase in central dopaminergic tone.
In addition, many treatments for psychosis that decrease central dopaminergic tone may decrease the effectiveness of rasagiline [see Drug Interactions ( 7.8 )] .
…patients can experience intense urges to gamble, increased sexual urges, intense urges to spend money, binge eating, and/or other intense urges, and the inability to control these urges while taking one or more of the medications, including rasagiline, that increase central dopaminergic tone and that are generally used for the treatment of Parkinson’s disease.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.