Theophylline and Verapamil interaction

Theophylline and Verapamil: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.

Moderate

Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.

What the FDA labels say

From the Verapamil (Verapamil Hydrochloride) label · effective 2025-03-25

Moderate

Theophylline Verapamil may inhibit the clearance and increase the plasma levels of theophylline.

Drug interactionsnames TheophyllineView label on DailyMed

From the Theophylline label · effective 2026-01-29

Minor

Verapamil Similar to disulfiram.

Drug interactionsnames VerapamilView label on DailyMed

Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.

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Not medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.