Pioglitazon: interakcje

Hypoglycemia Chloroquine has been shown to cause severe hypoglycemia including loss of consciousness that could be life-threatening in patients treated with or without antidiabetic medications (see PRECAUTIONS , Drug Interactions ). (etykieta leku Chlorochina, Ostrzeżenia)

Antidiabetic agents Hypoglycemia including fatal outcomes have been reported. (etykieta leku Cyprofloksacyna, Interakcje z innymi lekami)

Oral hypoglycemics Clinically significant hypoglycemia may be precipitated by the use of fluconazole with oral hypoglycemic agents; one fatality has been reported from hypoglycemia in association with combined fluconazole and glyburide use. (etykieta leku Flukonazol, Interakcje z innymi lekami)

This warning is based on the study conducted by the University Group Diabetes Program (UGDP), a long-term prospective clinical trial designed to evaluate the effectiveness of glucose-lowering drugs in preventing or delaying vascular complications in patients with non-insulin-dependent diabetes. (etykieta leku Glipizyd + metformina, Przeciwwskazania)

Hypoglycemia PLAQUENIL can cause severe and potentially life-threatening hypoglycemia, in the presence or absence of antidiabetic agents [see Drug Interactions (7) ]. (etykieta leku Hydroksychlorochina, Ostrzeżenia i środki ostrożności)

Hypoglycemia: Severe hypoglycemia has been reported in patients with pre-existing diabetes who are taking medications containing thiazolidinediones (including pioglitazone) or repaglinide. (etykieta leku Abirateron, Ostrzeżenia i środki ostrożności)

Consideration should be taken in patients being treated with antidiabetic agents. (etykieta leku Acetazolamid, Interakcje z innymi lekami)

Glyburide: In a trial of 7 healthy male volunteers, acitretin treatment potentiated the blood glucose-lowering effect of glyburide (a sulfonylurea similar to chlorpropamide) in 3 of the 7 subjects. (etykieta leku Acytretyna, Interakcje z innymi lekami)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Antidiabetic Agents: In rare cases, diabetic patients receiving an ACE inhibitor (including benazepril) concomitantly with insulin or oral antidiabetics may develop hypoglycemia. (etykieta leku Amlodypina + benazepryl, Interakcje z innymi lekami)

Some patients required either initiation or dose adjustments of insulin or oral hypoglycemic agents for treatment of these events. (etykieta leku Atazanawir, Ostrzeżenia i środki ostrożności)

Hypoglycemia Risk in Patients with Diabetes Mellitus In patients using insulin, agents enhancing insulin secretion (e.g., sulfonylureas), or insulin sensitizers (e.g., thiazolidinedione class), based on the mechanism of action, TARGRETIN could enhance the action of these agents, resulting in hypoglycemia. (etykieta leku Beksaroten, Ostrzeżenia i środki ostrożności)

Antidiabetics: Increased risk of hypoglycemia ( 7.2 ) (etykieta leku Benazepryl, Interakcje z innymi lekami)

Antidiabetic agents: Dosage adjustment of antidiabetic drug may be required. (etykieta leku Benazepryl + hydrochlorotiazyd, Interakcje z innymi lekami)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

However, patients subject to spontaneous hypoglycemia, or diabetic patients receiving insulin or oral hypoglycemic agents, should be cautioned about these possibilities and bisoprolol fumarate should be used with caution. (etykieta leku Bisoprolol, Ostrzeżenia)

Antidiabetic drugs (oral agents and insulin) - dosage adjustment of the antidiabetic drug may be required. (etykieta leku Bisoprolol + hydrochlorotiazyd, Środki ostrożności)

Masking of Hypoglycemic Symptoms in Patients with Diabetes Mellitus Beta-adrenergic blocking agents should be administered with caution in patients subject to spontaneous hypoglycemia or to diabetic patients (especially those with labile diabetes) who are receiving insulin or oral hypoglycemic agents. (etykieta leku Brymonidyna + tymolol, Ostrzeżenia i środki ostrożności)

Oral antidiabetic agents and insulin, causing hypoglycemia by contributing an additive effect, if dosage of Butalbital, Aspirin, and Caffeine Capsules exceeds maximum recommended daily dosage. (etykieta leku Butalbital + kwas acetylosalicylowy + kofeina, Interakcje z innymi lekami)

Evaluate the blood pressure and renal function of patients Examples: Metoprolol, propranolol Hypoglycemic Agents Clinical Impact: Aspirin may increase the serum glucose-lowering action of insulin and sulfonylureas leading to hypoglycemia. (etykieta leku Butalbital + kwas acetylosalicylowy + kofeina + kodeina, Interakcje z innymi lekami)

Antidiabetic Drugs (Oral Agents and Insulin) - dosage adjustment of the antidiabetic drug may be required. (etykieta leku Chlorotiazyd, Interakcje z innymi lekami)

Caution should be exercised when used with antidiabetic drugs. (etykieta leku Danazol, Interakcje z innymi lekami)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Initiation or dose adjustments of insulin or oral hypoglycemic agents may be required. (etykieta leku Darunawir, Ostrzeżenia i środki ostrożności)

Some patients required either initiation or dose adjustments of insulin or oral hypoglycemic agents for treatment of these events. (etykieta leku Darunawir + kobicystat, Ostrzeżenia i środki ostrożności)

• Strong CYP2C8 inhibitors (e.g., gemfibrozil) increase pioglitazone concentrations. (etykieta leku Pioglitazon, Interakcje z innymi lekami)

Hyperglycemia Corticosteroids can increase blood glucose, worsen pre-existing diabetes, and predispose those on long-term therapy to diabetes mellitus, and may reduce the effect of the antidiabetic drugs. (etykieta leku Deksametazon, Ostrzeżenia i środki ostrożności)

Masking of Hypoglycemic Symptoms in Patients with Diabetes Mellitus Beta-adrenergic blocking agents should be administered with caution in patients subject to spontaneous hypoglycemia or to diabetic patients (especially those with labile diabetes) who are receiving insulin or oral hypoglycemic agents. (etykieta leku Dorzolamid + tymolol, Ostrzeżenia i środki ostrożności)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

In diabetic patients dosage adjustments of insulin or oral hypoglycemic agents may be required. (etykieta leku Enalapryl + hydrochlorotiazyd, Środki ostrożności)

• A reduction in dose of insulin or oral hypoglycemic medication may be required in some patients. (etykieta leku Fentermina, Ostrzeżenia i środki ostrożności)

• Topiramate may decrease pioglitazone concentrations. (etykieta leku Pioglitazon, Interakcje z innymi lekami)

Monitor for symptoms of hyperglycemia; adjust dosage of antidiabetic drug upward if necessary. (etykieta leku Fludrokortyzon, Interakcje z innymi lekami)

As is true with many other types of medication when taken concurrently by patients with diabetes, insulin and/or oral hypoglycemic, dosage may need to be adjusted when therapy with PROZAC is instituted or discontinued. (etykieta leku Fluoksetyna, Ostrzeżenia i środki ostrożności)

Some patients required either initiation or dose adjustments of insulin or oral hypoglycemic agents for treatment of these events. (etykieta leku Fosamprenawir, Ostrzeżenia i środki ostrożności)

• Strong CYP2C8 inhibitors (e.g., gemfibrozil) increase pioglitazone concentrations. (etykieta leku Pioglitazon, Interakcje z innymi lekami)

• Hypoglycemia: When used with insulin or an insulin secretagogue, a lower dose of the insulin or insulin secretagogue may be needed to reduce the risk of hypoglycemia. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

• Hypoglycemia: When used with insulin or an insulin secretagogue, a lower dose of the insulin or insulin secretagogue may be needed to reduce the risk of hypoglycemia. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

• Hypoglycemia: When used with insulin or an insulin secretagogue, a lower dose of the insulin or insulin secretagogue may be needed to reduce the risk of hypoglycemia. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

• Hypoglycemia: When used with insulin or an insulin secretagogue, a lower dose of the insulin or insulin secretagogue may be needed to reduce the risk of hypoglycemia. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Antidiabetic drugs: Dosage adjustment of antidiabetic may be required (7.2) (etykieta leku Hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic Agents Clinical Impact: Corticosteroids in supraphysiologic doses may increase blood glucose concentrations. (etykieta leku Hydrokortyzon, Interakcje z innymi lekami)

Combination use with insulin and use in congestive heart failure NYHA Class I and II may increase risk. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Combination use with insulin and use in congestive heart failure NYHA Class I and II may increase risk. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Combination use with insulin and use in congestive heart failure NYHA Class I and II may increase risk. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Combination use with insulin and use in congestive heart failure NYHA Class I and II may increase risk. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Combination use with insulin and use in congestive heart failure NYHA Class I and II may increase risk. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Combination use with insulin and use in congestive heart failure NYHA Class I and II may increase risk. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Antidiabetic drugs: Dosage adjustment of antidiabetic may be required. (etykieta leku Irbesartan + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetic Drugs Repaglinide Saxagliptin Monitor for adverse reactions. (etykieta leku Itrakonazol, Interakcje z innymi lekami)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Antidiabetic drugs (oral agents and insulin) − Dosage adjustment of the antidiabetic drug may be required. (etykieta leku Kandesartan + hydrochlorotiazyd, Interakcje z innymi lekami)

• Strong CYP2C8 inhibitors (e.g., gemfibrozil) increase pioglitazone concentrations. (etykieta leku Pioglitazon, Interakcje z innymi lekami)

Closely monitor for adverse reactions of CYP2C9 substrates where minimal concentration changes may lead to serious adverse reactions when used concomitantly with XELODA (e.g., anticoagulants, antidiabetic drugs). (etykieta leku Kapecytabina, Interakcje z innymi lekami)

Insulin and oral hypoglycemics action may be enhanced. (etykieta leku Karwedilol, Interakcje z innymi lekami)

Antidiabetics repaglinide, saxagliptin Antihelmintics and Antiprotozoals praziquantel Antimigraine Drugs ergot alkaloids, such as dihydroergotamine, ergometrine (ergonovine), ergotamine, methylergometrine (methylergonovine) eletriptan Ergot alkaloids: The potential increase in plasma concentrations of ergot alkaloids when coadministered with ketoconazole tablets… (etykieta leku Ketokonazol, Interakcje z innymi lekami)

With certain hypoglycemic drugs such as nateglinide, pioglitazone, repaglinide and rosiglitazone, inhibition of CYP3A enzyme by clarithromycin may be involved and could cause hypoglycemia when used concomitantly. (etykieta leku Klarytromycyna, Ostrzeżenia i środki ostrożności)

…TG levels occurred when colesevelam hydrochloride was used as monotherapy (median increase 9.7% compared to placebo) and when colesevelam hydrochloride was used in combination with pioglitazone (median increase 11% compared to placebo in combination with pioglitazone), sulfonylureas (median increase 18% compared to placebo in combination with sulfonylureas), and… (etykieta leku Kolesewelam, Ostrzeżenia i środki ostrożności)

Oral Hypoglycemics Moderate doses of aspirin may increase the effectiveness of oral hypoglycemic drugs, leading to hypoglycemia. (etykieta leku Kwas acetylosalicylowy + dipirydamol, Interakcje z innymi lekami)

Hyperglycemia and Hypoglycemia : Glucose monitoring is recommended and antidiabetic treatment adjusted accordingly. (etykieta leku Lanreotyd, Ostrzeżenia i środki ostrożności)

In patients taking ARAVA, exposure of drugs metabolized by CYP2C8 (e.g., paclitaxel, pioglitazone, repaglinide, rosiglitazone) may be increased. (etykieta leku Leflunomid, Interakcje z innymi lekami)

Blood Glucose Disturbances Fluoroquinolones, including Levofloxacin in 5% Dextrose Injection, have been associated with disturbances of blood glucose, including symptomatic hyperglycemia and hypoglycemia, usually in diabetic patients receiving concomitant treatment with an oral hypoglycemic agent (e.g., glyburide) or with insulin. (etykieta leku Lewofloksacyna, Ostrzeżenia i środki ostrożności)

Worsening of Diabetic Control : May worsen glycemic control and result in increased antidiabetic agent or insulin requirements. (etykieta leku Lewotyroksyna, Ostrzeżenia i środki ostrożności)

Insulin or Oral Hypoglycemics — Initiating thyroid replacement therapy may cause increases in insulin or oral hypoglycemic requirements. (etykieta leku Lewotyroksyna + liotyronina, Interakcje z innymi lekami)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

• Hypoglycemia: Postmarketing cases of symptomatic hypoglycemia have been reported in patients with diabetes mellitus receiving insulin or oral hypoglycemic agents. (etykieta leku Linezolid, Ostrzeżenia i środki ostrożności)

• Worsening of diabetic control: Therapy in patients with diabetes mellitus may worsen glycemic control and result in increased antidiabetic agent or insulin requirements. (etykieta leku Liotyronina, Ostrzeżenia i środki ostrożności)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Antidiabetics Concomitant administration of Zestril and antidiabetic medicines (insulins, oral hypoglycemic agents) may cause an increased blood-glucose-lowering effect with risk of hypoglycemia. (etykieta leku Lizynopryl, Interakcje z innymi lekami)

Antidiabetic drugs (oral agents and insulin) - dosage adjustment of the antidiabetic drug may be required. (etykieta leku Lizynopryl + hydrochlorotiazyd, Interakcje z innymi lekami)

Some patients required either initiation or dose adjustments of insulin or oral hypoglycemic agents for treatment of these events. (etykieta leku Lopinawir + rytonawir, Ostrzeżenia i środki ostrożności)

Antidiabetic drugs: dosage adjustment of antidiabetic may be required. (etykieta leku Losartan + hydrochlorotiazyd, Interakcje z innymi lekami)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Insulin And Oral Antidiabetic Agents See Glucose Tolerance under PRECAUTIONS , General . (etykieta leku Metolazon, Interakcje z innymi lekami)

Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Metoprolol + hydrochlorotiazyd, Interakcje z innymi lekami)

Antidiabetics : Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required. (etykieta leku Metyloprednizolon, Interakcje z innymi lekami)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Antidiabetic agents Carefully monitor blood glucose. (etykieta leku Moksyfloksacyna, Interakcje z innymi lekami)

Beta-blockade also reduces the release of insulin in response to hyperglycemia; therefore, it may be necessary to adjust the dose of antidiabetic drugs. (etykieta leku Nadolol, Ostrzeżenia)

Use of Antidiabetic Medications: Weight loss may cause hypoglycemia. (etykieta leku Naltrekson + bupropion, Ostrzeżenia i środki ostrożności)

• Hypoglycemia: When used with insulin or an insulin secretagogue, a lower dose of the insulin or insulin secretagogue may be needed to reduce the risk of hypoglycemia. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

• Strong CYP2C8 inhibitors (e.g., gemfibrozil) increase pioglitazone concentrations. (etykieta leku Pioglitazon, Interakcje z innymi lekami)

Fluoroquinolones have been associated with disturbances of blood glucose, including symptomatic hyperglycemia and hypoglycemia, usually in diabetic patients receiving concomitant treatment with an oral hypoglycemic agent (e.g., glyburide) or with insulin. (etykieta leku Ofloksacyna, Ostrzeżenia)

Hypoglycemia or Hyperglycemia: Monitor glucose and adjust antidiabetic treatment as needed (‎ 5.2 ). (etykieta leku Oktreotyd, Ostrzeżenia i środki ostrożności)

• Increased amlodipine exposure when coadministered with CYP3A inhibitors Hydrochlorothiazide ( 7.3 ): • Antidiabetic drugs: Dosage adjustment of antidiabetic may be required. (etykieta leku Olmesartan + amlodypina + hydrochlorotiazyd, Interakcje z innymi lekami)

• Antidiabetic drugs: Dosage adjustment may be required. (etykieta leku Olmesartan + hydrochlorotiazyd, Interakcje z innymi lekami)

A reduction in dose of oral hypoglycemic medication (e.g., sulfonylureas) or insulin may be required in some patients [see Clinical Studies (14) ] . (etykieta leku Orlistat, Ostrzeżenia i środki ostrożności)

• Strong CYP2C8 inhibitors (e.g., gemfibrozil) increase pioglitazone concentrations. (etykieta leku Pioglitazon, Interakcje z innymi lekami)

Beta-blockade also reduces the release of insulin in response to hyperglycemia; therefore, it may be necessary to adjust the dose of antidiabetic drugs. (etykieta leku Pindolol, Ostrzeżenia)

• Hypoglycemia: When used with insulin or an insulin secretagogue, a lower dose of the insulin or insulin secretagogue may be needed to reduce the risk of hypoglycemia. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Antidiabetic Agents: Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required. (etykieta leku Prednizolon, Interakcje z innymi lekami)

Antidiabetic agents: May increase blood glucose concentrations. (etykieta leku Prednizon, Interakcje z innymi lekami)

Monitor patients for the development of edema when co-administering LYRICA CR and thiazolidinedione antidiabetic agents. (etykieta leku Pregabalina, Ostrzeżenia i środki ostrożności)

• Hypoglycemia: When used with insulin or an insulin secretagogue, a lower dose of the insulin or insulin secretagogue may be needed to reduce the risk of hypoglycemia. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

• CYP2C8 inducers (e.g., rifampin) may decrease pioglitazone concentrations. (etykieta leku Pioglitazon, Interakcje z innymi lekami)

…Diazepam Beta-Blockers Propranolol Calcium Channel Blockers Diltiazem, nifedipine, verapamil Cardiac Glycoside Preparations Digoxin Corticosteroids Prednisone Fibrates Clofibrate Oral Hypoglycemics Sulfonylureas (e.g., glyburide, glipizide) Hormonal Contraceptives/Progestins Ethinyl estradiol, levonorgestrel Immunosuppressants Cyclosporine, tacrolimus Methylxanthines… (etykieta leku Ryfapentyna, Interakcje z innymi lekami)

Some patients required either initiation or dose adjustments of insulin or oral hypoglycemic agents for treatment of these events. (etykieta leku Rytonawir, Ostrzeżenia i środki ostrożności)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Salicylates may enhance the hypoglycemic effect of oral antidiabetic drugs of the sulfonylurea class. (etykieta leku Salsalat, Interakcje z innymi lekami)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

The doses of antidiabetic agents may require adjustment when HUMATROPE is initiated. (etykieta leku Somatropina, Ostrzeżenia i środki ostrożności)

Insulin and Oral Antidiabetics Hyperglycemia may occur, and the dosage of insulin or antidiabetic drugs may require adjustment. (etykieta leku Sotalol, Interakcje z innymi lekami)

Antidiabetic drugs (e.g., oral agents, insulin): Dosage adjustment of the antidiabetic drug may be required (see Precautions ). (etykieta leku Spironolakton + hydrochlorotiazyd, Interakcje z innymi lekami)

• Strong CYP2C8 inhibitors (e.g., gemfibrozil) increase pioglitazone concentrations. (etykieta leku Pioglitazon, Interakcje z innymi lekami)

• Hypoglycemia : Check blood glucose levels regularly and assess if antidiabetic drug dose modifications are required. (etykieta leku Sunitynib, Ostrzeżenia i środki ostrożności)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Congestive Heart Failure ACTOS, like other thiazolidinediones, can cause dose-related fluid retention when used alone or in combination with other antidiabetic medications and is most common when ACTOS is used in combination with insulin. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Antidiabetic drugs: Dosage adjustment may be required ( 7.6 ) (etykieta leku Telmisartan + hydrochlorotiazyd, Interakcje z innymi lekami)

This may result in the need for an increase in the dose of, or initiation of, insulin and/or oral hypoglycemic agent therapy. (etykieta leku Temsyrolimus, Ostrzeżenia i środki ostrożności)

In patients taking AUBAGIO, exposure of drugs metabolized by CYP2C8 (e.g., paclitaxel, pioglitazone, repaglinide, rosiglitazone) may be increased. (etykieta leku Teryflunomid, Interakcje z innymi lekami)

• Topiramate may decrease pioglitazone concentrations. (etykieta leku Pioglitazon, Interakcje z innymi lekami)

(See PRECAUTIONS . ) Antidiabetic Agents Concomitant use of ACE inhibitors and antidiabetic medicines (insulin or oral hypoglycemic agents) may cause an increased blood glucose lowering effect with greater risk of hypoglycemia. (etykieta leku Trandolapryl, Interakcje z innymi lekami)

Hypoglycemia in Diabetic Patients Some MAOIs have contributed to hypoglycemic episodes in diabetic patients receiving insulin or other blood-glucose-lowering agents. (etykieta leku Tranylcypromina, Ostrzeżenia i środki ostrożności)

Antidiabetics: Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required. (etykieta leku Triamcynolon, Interakcje z innymi lekami)

Dyrenium (triamterene) may raise blood glucose levels; for adult-onset diabetes, dosage adjustments of hypoglycemic agents may be necessary during and/or after therapy; concurrent use with chlorpropamide may increase the risk of severe hyponatremia. (etykieta leku Triamteren, Interakcje z innymi lekami)

Oral Hypoglycemic Drugs Concurrent use with chlorpropamide may increase the risk of severe hyponatremia. (etykieta leku Triamteren + hydrochlorotiazyd, Interakcje z innymi lekami)

• Strong CYP2C8 inhibitors (e.g., gemfibrozil) increase pioglitazone concentrations. (etykieta leku Pioglitazon, Interakcje z innymi lekami)

Masking of Hypoglycemic Symptoms in Patients with Diabetes Mellitus Beta-adrenergic blocking agents should be administered with caution in patients subject to spontaneous hypoglycemia or to diabetic patients (especially those with labile diabetes) who are receiving insulin or oral hypoglycemic agents. (etykieta leku Tymolol, Ostrzeżenia i środki ostrożności)

Combination use with insulin and use in congestive heart failure NYHA Class I and II may increase risk. (etykieta leku Pioglitazon, Ostrzeżenia i środki ostrożności)

Hydrochlorothiazide: When administered concurrently, the following drugs may interact with thiazide diuretics: Antidiabetic Drugs (oral agents and insulin) - Dosage adjustment of the antidiabetic drug may be required. (etykieta leku Walsartan + hydrochlorotiazyd, Interakcje z innymi lekami)

…ritonavir, saquinavir, telithromycin, tipranavir, voriconazole, zileuton armodafinil, amprenavir, aprepitant, bosentan, carbamazepine, efavirenz, etravirine, modafinil, nafcillin, phenytoin, pioglitazone, prednisone, rifampin, rufinamide 7.3 Drugs that Increase Bleeding Risk Examples of drugs known to increase the risk of bleeding are presented in Table 3 . (etykieta leku Warfaryna, Interakcje z innymi lekami)

Sulfonylurea Oral Hypoglycemics (CYP2C9 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Frequent monitoring of blood glucose and for signs and symptoms of hypoglycemia. (etykieta leku Worykonazol, Interakcje z innymi lekami)

Antidiabetic drug requirements (i.e., insulin) may be altered. (etykieta leku Amfepramon (dietylopropion), Interakcje z innymi lekami)

Additional predisposing conditions include diabetes mellitus treated with oral hypoglycemic drugs or insulin, use of anorectic drugs, excessive use of alcohol, use of benzodiazepines, sedatives/hypnotics, or opiates. (etykieta leku Bupropion, Ostrzeżenia i środki ostrożności)

Insulin and Oral Hypoglycemic Medications Requirements may be altered. (etykieta leku Fendimetrazyna, Interakcje z innymi lekami)

In some cases, hyperglycemia has resolved when the atypical antipsychotic was discontinued; however, some patients required continuation of antidiabetic treatment despite discontinuation of the suspect drug. (etykieta leku Klozapina, Ostrzeżenia i środki ostrożności)

Oral Hypoglycemic Agents In pharmacokinetic studies of lovastatin in hypercholesterolemic non-insulin dependent diabetic patients, there was no drug interaction with glipizide or with chlorpropamide (see CLINICAL PHARMACOLOGY , Clinical Studies in Adults ). (etykieta leku Lowastatyna, Interakcje z innymi lekami)

Although the systemic absorption of miconazole following ORAVIG administration is minimal and plasma concentrations of miconazole are substantially lower than when given intravenously, the potential for interaction with drugs metabolized through CYP2C9 and CYP3A4 such as oral hypoglycemics, phenytoin, or ergot alkaloids cannot be ruled out. (etykieta leku Mikonazol, Interakcje z innymi lekami)

Moexipril hydrochloride has been used in clinical trials concomitantly with calcium-channel-blocking agents, diuretics, H 2 blockers, digoxin, oral hypoglycemic agents, and cholesterol-lowering agents. (etykieta leku Moeksypryl, Interakcje z innymi lekami)

Glucose Lowering Drugs Pioglitazone: Co-administration of pioglitazone for 7 days with 30 mg nifedipine ER administered orally q.d. for 4 days to male and female volunteers resulted in least square mean (90% CI) values for unchanged nifedipine of 0.83 (0.73-0.95) for C max and 0.88 (0.80-0.96) for AUC relative to nifedipine monotherapy. (etykieta leku Nifedypina, Środki ostrożności)

Moderate and weak CYP3A4 inducers include, for example: amprenavir, aprepitant, armodafinil, bosentan, efavirnenz, etravirine, Echinacea, modafinil, nafcillin, pioglitazone, prednisone, rufinamide, and vemurafenib. (etykieta leku Nimodypina, Interakcje z innymi lekami)

Potentiation of the action of sulfonylurea hypoglycemic agents, thiazide diuretics and uricosuric agents may also be noted. (etykieta leku Sulfadiazyna, Interakcje z innymi lekami)

Drug Interactions with Amlodipine In clinical trials, amlodipine has been safely administered with thiazide diuretics, beta-blockers, angiotensin-converting enzyme inhibitors, long-acting nitrates, sublingual nitroglycerin, digoxin, warfarin, non-steroidal anti-inflammatory drugs, antibiotics, and oral hypoglycemic drugs. (etykieta leku Telmisartan + amlodypina, Interakcje z innymi lekami)

Hypoglycemic Agents: In adult diabetic patients under treatment with either sulfonylureas or insulin there is no change in the clinical effects of either TOLECTIN or the hypoglycemic agents. (etykieta leku Tolmetyna, Interakcje z innymi lekami)

In some cases, hyperglycemia has resolved when the atypical antipsychotic was discontinued; however, some patients required continuation of antidiabetic treatment despite discontinuation of the suspect drug. (etykieta leku Zyprazydon, Ostrzeżenia i środki ostrożności)

Oral hypoglycemic agents Although sulindac and its sulfide metabolite are highly bound to protein, studies in which sulindac was given at a dose of 400 mg daily, have shown no clinically significant interaction with oral hypoglycemic agents. (etykieta leku Sulindak, Interakcje z innymi lekami)