Witamina K: interakcje

Patients with a hemorrhagic diathesis (e.g., hemophilia, hypoprothrombinemia, von Willebrand's disease, the thrombocytopenias, thrombasthenia and other ill-defined hereditary platelet dysfunctions, severe vitamin K deficiency and severe liver damage). (etykieta leku Butalbital + kwas acetylosalicylowy + kofeina, Przeciwwskazania)

A potentially life-threatening bleeding disorder related to decreased levels of vitamin K-dependent clotting factors may occur in newborns exposed to phenytoin in utero. (etykieta leku Fenytoina, Ostrzeżenia i środki ostrożności)

Do not administer agents that enhance the risk of hemorrhage with fondaparinux sodium unless essential for the management of the underlying condition, such as vitamin K antagonists for the treatment of VTE. (etykieta leku Fondaparynuks, Ostrzeżenia i środki ostrożności)

A potentially life-threatening bleeding disorder related to decreased levels of vitamin K-dependent clotting factors may occur in newborns exposed to phenytoin in utero. (etykieta leku Fosfenytoina, Ostrzeżenia i środki ostrożności)

WARNING: SERIOUS ADVERSE REACTIONS OR DEATH IN PATIENTS WITH COMPLETE DPD DEFICIENCY and INCREASED RISK OF BLEEDING WITH CONCOMITANT USE OF VITAMIN K ANTAGONISTS Increased risk of serious adverse reactions or death in patients with complete DPD deficiency • Test patients for genetic variants of DPYD prior to initiating XELODA unless immediate treatment is necessary. (etykieta leku Kapecytabina, Ostrzeżenie w ramce)

Postmarketing reports suggest that concomitant administration of high doses of cefazolin and rifampin may prolong the prothrombin time, leading to severe vitamin K–dependent coagulation disorders that may be life-threatening or fatal. (etykieta leku Ryfampicyna, Ostrzeżenia)

Witamina K osłabia przeciwzakrzepowe działanie warfaryny; nagłe zmiany jej spożycia z suplementów lub diety mogą rozchwiać INR. (NIH Office of Dietary Supplements, Vitamin K)

For patients with APS (especially those who are triple positive [positive for lupus anticoagulant, anticardiolipin, and anti-beta 2-glycoprotein I antibodies]), treatment with DOACs has been associated with increased rates of recurrent thrombotic events compared with vitamin K antagonist therapy. (etykieta leku Apiksaban, Ostrzeżenia i środki ostrożności)

Some patients had serious bleeding including intracranial, retroperitoneal, and gastrointestinal requiring blood transfusion and/or administration of vitamin K. (etykieta leku Bikalutamid, Ostrzeżenia i środki ostrożności)

This can adversely affect patients with inherited (i.e. hemophilia) or acquired (i.e. liver disease or vitamin K deficiency) bleeding disorders. (etykieta leku Butalbital + kwas acetylosalicylowy + kofeina + kodeina, Ostrzeżenia i środki ostrożności)

Prothrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicated (5.5) (etykieta leku Cefazolina, Ostrzeżenia i środki ostrożności)

Prothrombin time should be monitored in patients at risk, and exogenous vitamin K administered as indicated. (etykieta leku Cefepim, Ostrzeżenia i środki ostrożności)

Prothrombin time should be monitored in patients at risk and exogenous vitamin K administered as indicated. (etykieta leku Cefiksym, Ostrzeżenia i środki ostrożności)

Prothrombin time should be monitored and exogenous vitamin K administered as indicated. (etykieta leku Cefotetan, Ostrzeżenia)

Patients with impaired vitamin K synthesis or low vitamin K stores (e.g., chronic hepatic disease and malnutrition) may require monitoring of prothrombin time during Ceftriaxone for Injection and Dextrose Injection treatment. (etykieta leku Ceftriakson, Ostrzeżenia i środki ostrożności)

Warfarin and oral anticoagulants Cinchona alkaloids, including quinine, may have the potential to depress hepatic enzyme synthesis of vitamin K-dependent coagulation pathway proteins and may enhance the action of warfarin and other oral anticoagulants. (etykieta leku Chinina, Interakcje z innymi lekami)

For patients with APS (especially those who are triple-positive [positive for lupus anticoagulant, anticardiolipin, and anti-beta 2-glycoprotein I antibodies]), treatment with DOACs has been associated with increased rates of recurrent thrombotic events compared with vitamin K antagonist therapy. (etykieta leku Dabigatran, Ostrzeżenia i środki ostrożności)

For patients with APS (especially those who are triple positive [positive for lupus anticoagulant, anticardiolipin antibodies, and anti-beta 2-glycoprotein I antibodies]), treatment with DOACs has been associated with increased rates of recurrent thrombotic events compared with vitamin K antagonist therapy. (etykieta leku Edoksaban, Ostrzeżenia i środki ostrożności)

Vitamin K or Fat-Soluble Vitamin Deficiencies: Colesevelam hydrochloride may decrease absorption of fat-soluble vitamins. (etykieta leku Kolesewelam, Ostrzeżenia i środki ostrożności)

Drug Interactions Oral Anticoagulants — Thyroid hormones appear to increase catabolism of vitamin K-dependent clotting factors. (etykieta leku Lewotyroksyna + liotyronina, Interakcje z innymi lekami)

Oral neomycin sulfate may enhance the effect of coumarin in anticoagulants by decreasing vitamin K availability. (etykieta leku Neomycyna, Interakcje z innymi lekami)

The effect of ORLISTAT on the absorption of supplemental vitamin D, vitamin A, and nutritionally-derived vitamin K is not known at this time [see Clinical Pharmacology (12.3) , and Warnings and Precautions (5.1) ] . (etykieta leku Orlistat, Interakcje z innymi lekami)

Increased prothrombin time has been reported in patients concomitantly treated with pentoxifylline and vitamin K antagonists. (etykieta leku Pentoksyfilina, Interakcje z innymi lekami)

Drug Interactions Anticoagulants (oral) : Due to the potential inhibition of vitamin K activity by propylthiouracil, the activity of oral anticoagulants (e.g., warfarin) may be increased; additional monitoring of PT/INR should be considered, especially before surgical procedures. (etykieta leku Propylotiouracyl, Interakcje z innymi lekami)

For patients with APS (especially those who are triple positive [positive for lupus anticoagulant, anticardiolipin, and anti-beta 2-glycoprotein I antibodies]), treatment with DOACs has been associated with increased rates of recurrent thrombotic events compared with vitamin K antagonist therapy. (etykieta leku Rywaroksaban, Ostrzeżenia i środki ostrożności)

In vitro experiments demonstrated additional aPTT and PT(INR) prolongations for sugammadex in combination with vitamin K antagonists, unfractionated heparin, low molecular weight heparinoids, rivaroxaban, and dabigatran up to ~25% and ~50% at C max levels of sugammadex corresponding to 4 mg/kg and 16 mg/kg doses, respectively. (etykieta leku Sugammadeks, Ostrzeżenia i środki ostrożności)

Drug Interactions Anticoagulants (oral): Due to potential inhibition of vitamin K activity by methimazole, the activity of oral anticoagulants (e.g., warfarin) may be increased; additional monitoring of PT/INR should be considered, especially before surgical procedures. β-adrenergic blocking agents: Hyperthyroidism may cause an increased clearance of beta blockers… (etykieta leku Tiamazol, Interakcje z innymi lekami)

Cutaneous Reactions Parenteral administration of vitamin K replacements (including phytonadione injectable emulsion) may cause cutaneous reactions. (etykieta leku Fitomenadion (witamina K1), Ostrzeżenia i środki ostrożności)

Methylergonovine maleate has been administered instead of vitamin K and Hepatitis B vaccine, medications which are routinely administered to the newborn. (etykieta leku Metyloergometryna, Ostrzeżenia)

Neonatal hemorrhage, with a coagulation defect resembling vitamin K deficiency, has been described in newborns whose mothers were taking primidone and other anticonvulsants. (etykieta leku Prymidon, Ostrzeżenia)