Interações de Ampicilina + sulbactam
Ampicilina + sulbactam (Unasyn), antibiótico da classe das penicilinas, tem 80 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 31; moderadas: 34; leves: 13; casos em que uma bula relata não haver interação significativa: 2). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.
Interações segundo a bula
Interações graves (31)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
Since bacteriostatic drugs may interfere with the bactericidal action of penicillins, it is advisable to avoid giving tetracycline-class drugs in conjunction with penicillin. (bula de Demeclociclina, Interações medicamentosas)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
Avoid co-administration of tetracyclines with penicillin. (bula de Doxiciclina, Interações medicamentosas)
INVANZ is contraindicated in patients with known hypersensitivity to any component of this product or to other drugs in the same class or in patients who have demonstrated anaphylactic reactions to beta-lactams. (bula de Ertapeném, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
Hypersensitivity Reactions: Serious and occasionally fatal hypersensitivity (anaphylactic) reactions have been reported in patients receiving therapy with beta-lactams. (bula de Imipeném + cilastatina, Advertências e precauções)
Penicillin Because bacteriostatic drugs may interfere with the bactericidal action of penicillin, avoid giving EMROSI in conjunction with penicillin. (bula de Minociclina, Interações medicamentosas)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
CONTRAINDICATIONS The use of UNASYN is contraindicated in individuals with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to ampicillin, sulbactam or to other beta-lactam antibacterial drugs (e.g., penicillins and cephalosporins). (bula de Ampicilina + sulbactam, Contraindicações)
Drug Interactions Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracycline in conjunction with penicillin or other bactericidal antibacterials. (bula de Tetraciclina, Interações medicamentosas)
Interações moderadas (34)
The concurrent administration of allopurinol and ampicillin increases substantially the incidence of rashes in patients receiving both drugs as compared to patients receiving ampicillin alone. (bula de Ampicilina + sulbactam, Interações medicamentosas)
Use caution when CAYSTON is administered to patients with a known allergic reaction to beta-lactams. (bula de Aztreonam, Advertências e precauções)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Benazepril + hidroclorotiazida, Advertências)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Bisoprolol + hidroclorotiazida, Advertências)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Candesartana + hidroclorotiazida, Advertências)
Ampicillin: In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin. (bula de Cloroquina, Interações medicamentosas)
The absorption of tetracycline, furosemide, penicillin G, hydrochlorothiazide, and gemfibrozil was significantly decreased when given simultaneously with colestipol hydrochloride; these drugs were not tested to determine the effect of administration one hour before colestipol hydrochloride. (bula de Colestipol, Interações medicamentosas)
Drug Interactions Cholestyramine for Oral Suspension USP may delay or reduce the absorption of concomitant oral medication such as phenylbutazone, warfarin, thiazide diuretics (acidic), or propranolol (basic), as well as tetracycline, penicillin G, phenobarbital, thyroid and thyroxine preparations, estrogens and progestins, and digitalis. (bula de Colestiramina, Interações medicamentosas)
Drugs that Cause Hypokalemia The risk of hypokalemia is greater with coadministration of KEVEYIS and other drugs that can cause hypokalemia (e.g., loop diuretics, thiazide diuretics, laxatives, antifungals, penicillins, and theophylline) [see Warnings and Precautions (5.3) ] . (bula de Diclorfenamida, Interações medicamentosas)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Enalapril + hidroclorotiazida, Advertências)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Espironolactona + hidroclorotiazida, Advertências)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Hidroclorotiazida, Advertências e precauções)
Ampicillin In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin. (bula de Hidroxicloroquina, Interações medicamentosas)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Irbesartana + hidroclorotiazida, Advertências e precauções)
Examples of relevant classes of compounds where antacids have been demonstrated to reduce bioavailability include antibiotics (such as quinolones, ampicillin, and tetracyclines), thyroid hormones, ACE inhibitors, statin lipid regulators, and anti-malarials. (bula de Lantânio, Interações medicamentosas)
In patients taking ARAVA, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased. (bula de Leflunomida, Interações medicamentosas)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Lisinopril + hidroclorotiazida, Advertências)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Losartana + hidroclorotiazida, Advertências e precauções)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Metoprolol + hidroclorotiazida, Advertências e precauções)
Effect of Other Drugs on XATMEP Oral Antibiotics Penicillins may reduce the renal clearance of methotrexate; increased serum concentrations of methotrexate with concomitant hematologic and gastrointestinal toxicity have been observed with methotrexate. (bula de Metotrexato, Interações medicamentosas)
Examples Cyclosporine A, trimethoprim/sulfamethoxazole, bile acid sequestrants (cholestyramine), rifampin as well as aminoglycoside, cephalosporin, fluoroquinolone and penicillin classes of antimicrobials Drugs Modulating Glucuronidation Clinical Impact Concomitant use with drugs inducing glucuronidation decreases MPA systemic exposure, potentially reducing mycophenolate… (bula de Micofenolato, Interações medicamentosas)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Olmesartana + anlodipino + hidroclorotiazida, Advertências e precauções)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Olmesartana + hidroclorotiazida, Advertências e precauções)
- ProbenecidaModerada
Drug Interactions Probenecid decreases the renal tubular secretion of ampicillin and sulbactam. (bula de Ampicilina + sulbactam, Interações medicamentosas)
- Probenecida + colchicinaModerada
Drug Interactions Probenecid decreases the renal tubular secretion of ampicillin and sulbactam. (bula de Ampicilina + sulbactam, Interações medicamentosas)
- ProtaminaModerada
Drug Interactions Protamine sulfate has been shown to be incompatible with certain antibiotics, including several of the cephalosporins and penicillins (see DOSAGE AND ADMINISTRATION ). (bula de Protamina, Precauções)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Quinapril + hidroclorotiazida, Advertências)
Salicylate competes with a number of drugs for protein binding sites, notably penicillin, thiopental, thyroxine, triiodothyronine, phenytoin, sulfinpyrazone, naproxen, warfarin, methotrexate, and possibly corticosteroids. [When Salsalate tablets, USP are administered with aspirin, its protein binding is reduced, although the clearance of free Salsalate tablets,… (bula de Salsalato, Interações medicamentosas)
Drugs that May Enhance the Neuromuscular Blocking Action of Succinylcholine : promazine, oxytocin, aprotinin, certain non-penicillin antibiotics, quinidine, β-adrenergic blockers, procainamide, lidocaine, trimethaphan, lithium carbonate, magnesium salts, quinine, chloroquine, isoflurane, desflurane, metoclopramide, terbutaline, and drugs that reduce plasma cholinesterase… (bula de Suxametônio (succinilcolina), Interações medicamentosas)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Telmisartana + hidroclorotiazida, Advertências e precauções)
In patients taking AUBAGIO, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased. (bula de Teriflunomida, Interações medicamentosas)
…from blood bank (may contain up to 30 mEq of potassium per liter of plasma or up to 65 mEq per liter of whole blood when stored for more than 10 days); low-salt milk (may contain up to 60 mEq of potassium per liter); potassium-containing medications (such as parenteral penicillin G potassium); salt substitutes (most contain substantial amounts of potassium). (bula de Triantereno, Interações medicamentosas)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Triantereno + hidroclorotiazida, Advertências)
Risk factors for developing acute angle-closure glaucoma may include a history of sulfonamide or penicillin allergy. (bula de Valsartana + hidroclorotiazida, Advertências e precauções)
Menções leves (13)
UNASYN and aminoglycosides should not be reconstituted together due to the in vitro inactivation of aminoglycosides by the ampicillin component of UNASYN. (bula de Ampicilina + sulbactam, Interações medicamentosas)
These include probenecid, cholestyramine, and some antibiotics (e.g., erythromycin, rifampicin, ampicillin and chloramphenicol). (bula de Carbidopa + levodopa + entacapona, Interações medicamentosas)
A similar association, though less marked, has been suggested for barbiturates, phenylbutazone, phenytoin sodium, and possibly with griseofulvin, ampicillin, and tetracyclines. (bula de Diacetato de etinodiol + etinilestradiol, Interações medicamentosas)
- EntacaponaLeve
These include probenecid, cholestyramine, and some antibiotics (e.g., erythromycin, rifampicin, ampicillin, and chloramphenicol). (bula de Entacapona, Precauções)
Infants born to women treated during pregnancy with oral erythromycin for early syphilis should be treated with an appropriate penicillin regimen. (bula de Eritromicina, Advertências)
Some antibiotics such as penicillin may compete with phenylacetylglutamine and hippurate for active secretion by renal tubules, which may affect the overall disposition of the infused drug. (bula de Fenilacetato de sódio + benzoato de sódio, Interações medicamentosas)
UNASYN and aminoglycosides should not be reconstituted together due to the in vitro inactivation of aminoglycosides by the ampicillin component of UNASYN. (bula de Ampicilina + sulbactam, Interações medicamentosas)
There have been reports of individuals with a history of penicillin hypersensitivity who have experienced severe hypersensitivity reactions when treated with another β-lactam. (bula de Meropeném, Advertências e precauções)
UNASYN and aminoglycosides should not be reconstituted together due to the in vitro inactivation of aminoglycosides by the ampicillin component of UNASYN. (bula de Ampicilina + sulbactam, Interações medicamentosas)
- PenicilaminaLeve
Patients who are allergic to penicillin may theoretically have cross-sensitivity to penicillamine. (bula de Penicilamina, Precauções)
UNASYN and aminoglycosides should not be reconstituted together due to the in vitro inactivation of aminoglycosides by the ampicillin component of UNASYN. (bula de Ampicilina + sulbactam, Interações medicamentosas)
Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (bula de Raloxifeno, Interações medicamentosas)
UNASYN and aminoglycosides should not be reconstituted together due to the in vitro inactivation of aminoglycosides by the ampicillin component of UNASYN. (bula de Ampicilina + sulbactam, Interações medicamentosas)
Nenhuma interação significativa relatada (2)
…Produce No Clinically Significant Interaction With Theophylline Refer to PRECAUTIONS , Drug Interactions for information regarding table. albuterol, systemic and inhaled amoxicillin ampicillin, with or without sulbactam atenolol azithromycin caffeine, dietary ingestion cefaclor co-trimoxazole (trimethoprim and sulfamethoxazole) diltiazem dirithromycin enflurane… (bula de Aminofilina, Interações medicamentosas)
…interact with theophylline or drugs that produce no clinically significant interaction with theophylline.* albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without methylprednisolone sulbactam metronidazole atenolol metoprolol azithromycin nadolol caffeine, dietary ingestion nifedipine cefaclor nizatidine co-trimoxazole… (bula de Teofilina, Interações medicamentosas)
Verifique Ampicilina + sulbactam com tudo o que você toma. Adicione sua lista completa; todos os pares são verificados de uma vez.
Abrir no verificadorNão é aconselhamento médico. A gravidade reflete a redação da bula, não as suas circunstâncias. Um alerta “grave” pode ser rotina sob supervisão, e um “leve” pode ser importante em doses altas. Pergunte a um farmacêutico.