Interações de Axitinibe
Axitinibe (Inlyta) tem 128 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 33; moderadas: 62; leves: 33; casos em que uma bula relata não haver interação significativa: 0). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.
Interações segundo a bula
Interações graves (33)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Moderate CYP3A4/5 inducers (e.g., bosentan, efavirenz, etravirine, modafinil, and nafcillin) may also reduce the plasma exposure of axitinib and should be avoided if possible. (bula de Axitinibe, Interações medicamentosas)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Moderate CYP3A4/5 inducers (e.g., bosentan, efavirenz, etravirine, modafinil, and nafcillin) may also reduce the plasma exposure of axitinib and should be avoided if possible. (bula de Axitinibe, Interações medicamentosas)
Moderate CYP3A4/5 inducers (e.g., bosentan, efavirenz, etravirine, modafinil, and nafcillin) may also reduce the plasma exposure of axitinib and should be avoided if possible. (bula de Axitinibe, Interações medicamentosas)
Moderate CYP3A4/5 inducers (e.g., bosentan, efavirenz, etravirine, modafinil, and nafcillin) may also reduce the plasma exposure of axitinib and should be avoided if possible. (bula de Axitinibe, Interações medicamentosas)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Axitinib Bosutinib Cabazitaxel Cabozantinib Ceritinib Cobimetinib Crizotinib Dabrafenib Dasatinib Docetaxel Ibrutinib Lapatinib Nilotinib Olaparib Pazopanib Sunitinib Trabectedin Trastuzumab-emtansine Vinca alkaloids Not recommended during and 2 weeks after TOLSURA treatment. (bula de Itraconazol, Interações medicamentosas)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Moderate CYP3A4/5 inducers (e.g., bosentan, efavirenz, etravirine, modafinil, and nafcillin) may also reduce the plasma exposure of axitinib and should be avoided if possible. (bula de Axitinibe, Interações medicamentosas)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Moderate CYP3A4/5 inducers (e.g., bosentan, efavirenz, etravirine, modafinil, and nafcillin) may also reduce the plasma exposure of axitinib and should be avoided if possible. (bula de Axitinibe, Interações medicamentosas)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
- SorafenibeGrave
Fatal cerebrovascular accident was reported in 1/359 patients (<1%) receiving INLYTA and none of the patients receiving sorafenib [see Adverse Reactions (6.1) ] . (bula de Axitinibe, Advertências e precauções)
Grapefruit or grapefruit juice may also increase axitinib plasma concentrations and should be avoided. (bula de Axitinibe, Interações medicamentosas)
Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)
Tyrosine kinase inhibitors (including but not limited to axitinib, bosutinib, cabozantinib, ceritinib, cobimetinib, dabrafenib, dasatinib, nilotinib, sunitinib, ibrutinib, ribociclib) (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Avoid concomitant use of voriconazole. (bula de Voriconazol, Interações medicamentosas)
Interações moderadas (62)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
Monitor thyroid function before initiation of, and periodically throughout, treatment with INLYTA. (bula de Axitinibe, Advertências e precauções)
Monitor thyroid function before initiation of, and periodically throughout, treatment with INLYTA. (bula de Axitinibe, Advertências e precauções)
Monitor thyroid function before initiation of, and periodically throughout, treatment with INLYTA. (bula de Axitinibe, Advertências e precauções)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
Monitor thyroid function before initiation of, and periodically throughout, treatment with INLYTA. (bula de Axitinibe, Advertências e precauções)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
Monitor thyroid function before initiation of, and periodically throughout, treatment with INLYTA. (bula de Axitinibe, Advertências e precauções)
Monitor thyroid function before initiation of, and periodically throughout, treatment with INLYTA. (bula de Axitinibe, Advertências e precauções)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inducers Co-administration of rifampin, a strong inducer of CYP3A4/5, reduced the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
CYP3A4/5 Inhibitors Co-administration of ketoconazole, a strong inhibitor of CYP3A4/5, increased the plasma exposure of axitinib in healthy volunteers. (bula de Axitinibe, Interações medicamentosas)
Menções leves (33)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Co-administration of INLYTA with strong CYP3A4/5 inducers (e.g., rifampin, dexamethasone, phenytoin, carbamazepine, rifabutin, rifapentine, phenobarbital, and St. (bula de Axitinibe, Interações medicamentosas)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
- SunitinibeLeve
MACE occurred in 7% of patients with advanced RCC treated with INLYTA in combination with avelumab compared to 3.4% treated with sunitinib in a randomized trial, JAVELIN Renal 101. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Thirty-four patients were treated with corticosteroids and one patient was treated with a non-steroidal immunosuppressant. (bula de Axitinibe, Advertências e precauções)
Verifique Axitinibe com tudo o que você toma. Adicione sua lista completa; todos os pares são verificados de uma vez.
Abrir no verificadorNão é aconselhamento médico. A gravidade reflete a redação da bula, não as suas circunstâncias. Um alerta “grave” pode ser rotina sob supervisão, e um “leve” pode ser importante em doses altas. Pergunte a um farmacêutico.