Interações de Deflazacorte

Deflazacorte (Emflaza, Jaythari, Kymbee), corticosteroide, tem 334 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 61; moderadas: 199; leves: 74; casos em que uma bula relata não haver interação significativa: 0). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.

Interações segundo a bula

Interações graves (61)

  • Abirateronainibidor da CYP2D6Grave

    At the primary analysis, increased incidences of fractures (28.6% vs 11.4%) and deaths (38.5% vs 35.5%) have been observed in patients who received abiraterone acetate plus a corticosteroid in combination with radium Ra 223 dichloride compared to patients who received placebo in combination with abiraterone acetate plus a corticosteroid. (bula de Abiraterona, Advertências e precauções)

  • AdalimumabeimunossupressorGrave

    Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids. (bula de Adalimumabe, Advertência em caixa preta)

  • ÁlcoolÁlcoolGrave

    Serious and fatal adverse reactions including “gasping syndrome” can occur in neonates and low birth weight infants treated with benzyl alcohol-preserved drugs, including EMFLAZA. (bula de Deflazacorte, Advertências e precauções)

  • Aprepitantoinibidor da CYP3A4Grave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Arformoterolagonista beta-adrenérgicoGrave

    Use of a LABA, including arformoterol tartrate inhalation solution, without an inhaled corticosteroid is contraindicated in patients with asthma. (bula de Arformoterol, Contraindicações)

  • Armodafinilaestimulante do SNCGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • AtazanavirantirretroviralGrave

    Coadministration of fluticasone propionate and REYATAZ with ritonavir is not recommended unless the potential benefit to the patient outweighs the risk of systemic corticosteroid side effects [see Warnings and Precautions (5.1) ] . (bula de Atazanavir, Interações medicamentosas)

  • Withhold INLYTA and avelumab or pembrolizumab, initiate corticosteroid therapy as needed, and/or permanently discontinue the combination for severe or life-threatening hepatotoxicity. (bula de Axitinibe, Advertências e precauções)

  • Baricitinibeinibidor da JAKGrave

    Most patients with rheumatoid arthritis who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids. (bula de Baricitinibe, Advertência em caixa preta)

  • Bosentanaindutor da CYP3A4Grave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • CarbamazepinaanticonvulsivanteGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • CenobamatoanticonvulsivanteGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Cetoconazolantifúngico azólicoGrave

    Fluticasone: Coadministration of fluticasone propionate and ketoconazole is not recommended unless the potential benefit to the patient outweighs the risk of systemic corticosteroid side effects. (bula de Cetoconazol, Interações medicamentosas)

  • ClobazambenzodiazepínicoGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Deferasiroxsuplemento de ferroGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • DexametasonacorticosteroideGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Severe hypersensitivity reactions characterized by generalized rash/erythema, hypotension and/or bronchospasm, or fatal anaphylaxis, have been reported in patients premedicated with 3 days of corticosteroids. (bula de Docetaxel, Advertências e precauções)

  • EfavirenzantirretroviralGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • …(5.7) , Drug Interactions (7) , and Clinical Pharmacology (12.3) ]: Anticonvulsants: carbamazepine, oxcarbazepine, phenobarbital, phenytoin Antimycobacterials: rifampin, rifapentine Glucocorticoid (systemic): dexamethasone (more than a single-dose) Herbal Products: St John's wort ( Hypericum perforatum ) Proton Pump Inhibitors: e.g., dexlansoprazole, esomeprazole,… (bula de Entricitabina + rilpivirina + tenofovir, Contraindicações)

  • Epinefrina (adrenalina)simpaticomiméticoGrave

    …Antihistamines Thyroid hormones Diuretics Cardiac glycosides, such as digitalis glycosides Quinidine Drugs potentiating hypokalemic effects of epinephrine • Potassium depleting diuretics • Corticosteroids • Theophylline Epinephrine should not be used to counteract circulatory collapse or hypotension caused by phenothiazines, as a reversal of the pressor effects of epinephrine… (bula de Epinefrina (adrenalina), Interações medicamentosas)

  • EslicarbazepinaanticonvulsivanteGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • EtanercepteimunossupressorGrave

    Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids. (bula de Etanercepte, Advertência em caixa preta)

  • EtravirinaantirretroviralGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • FenitoínaanticonvulsivanteGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • FenobarbitalbarbitúricoGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Fentermina + topiramatoestimulante do SNCGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Formoterolagonista beta-adrenérgicoGrave

    Use of a LABA, including formoterol fumarate inhalation solution, without an inhaled corticosteroid is contraindicated in patients with asthma [see Warnings and Precautions (5.1) ]. (bula de Formoterol, Contraindicações)

  • FosamprenavirantirretroviralGrave

    Coadministration of fluticasone and fosamprenavir calcium/ritonavir is not recommended unless the potential benefit to the patient outweighs the risk of systemic corticosteroid side effects. (bula de Fosamprenavir, Interações medicamentosas)

  • FosfenitoínaanticonvulsivanteGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • GriseofulvinaantifúngicoGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • InfliximabeimunossupressorGrave

    Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids. (bula de Infliximabe, Advertência em caixa preta)

  • Lopinavir + ritonavirantirretroviralGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Lorlatinibeindutor da CYP3A4Grave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • LovastatinaestatinaGrave

    Moreover, cholesterol and other products of the cholesterol biosynthesis pathway are essential components for fetal development, including synthesis of steroids and cell membranes. (bula de Lovastatina, Contraindicações)

  • Mifepristonainibidor da CYP3A4Grave

    WARNING: TERMINATION OF PREGNANCY Mifepristone is a potent antagonist of progesterone and cortisol via the progesterone and glucocorticoid (GR-II) receptors, respectively. (bula de Mifepristona, Advertência em caixa preta)

  • Mitapivateindutor da CYP3A4Grave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Mitotanoindutor da CYP3A4Grave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Modafinilaestimulante do SNCGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Moexiprilinibidor da ECAGrave

    None of the cases were considered life-threatening and all resolved either without treatment or with medication (antihistamines or glucocorticoids). (bula de Moexipril, Advertências)

  • Nafcilinaantibiótico da classe das penicilinasGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • NevirapinaantirretroviralGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • OxcarbazepinaanticonvulsivanteGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • PrimidonaanticonvulsivanteGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • RifabutinaantibióticoGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • RifampicinaantibióticoGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • RifapentinaantibióticoGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • RilpivirinaantirretroviralGrave

    Antimycobacterials Rifampin Rifapentine Glucocorticoid (systemic) Dexamethasone (more than a single-dose treatment) Herbal Products St. (bula de Rilpivirina, Contraindicações)

  • RitonavirantirretroviralGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Salmeterolagonista beta-adrenérgicoGrave

    WARNING: ASTHMA-RELATED DEATH Long-acting beta 2 -adrenergic agonists (LABA), such as salmeterol, the active ingredient in SEREVENT DISKUS, as monotherapy (without inhaled corticosteroids [ICS]) increase the risk of asthma-related death. (bula de Salmeterol, Advertência em caixa preta)

  • SirolimoimunossupressorGrave

    In a multicenter clinical study, de novo renal transplant patients treated with sirolimus, mycophenolate mofetil (MMF), steroids, and an IL-2 receptor antagonist had significantly higher acute rejection rates and numerically higher death rates compared to patients treated with cyclosporine, MMF, steroids, and IL-2 receptor antagonist. (bula de Sirolimo, Advertências e precauções)

  • Intervention: Carefully adjust glucocorticoid dosing in pediatric patients receiving glucocorticoid treatments to avoid both hypoadrenalism and an inhibitory effect on growth. (bula de Somatropina, Interações medicamentosas)

  • Suzetriginaindutor da CYP3A4Grave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • TocilizumabeimunossupressorGrave

    Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids. (bula de Tocilizumabe, Advertência em caixa preta)

  • TofacitinibeimunossupressorGrave

    Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids. (bula de Tofacitinibe, Advertência em caixa preta)

  • TopiramatoanticonvulsivanteGrave

    Avoid use of moderate or strong CYP3A4 inducers with EMFLAZA, as they may reduce efficacy ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Trandolaprilinibidor da ECAGrave

    Two of the four cases were life-threatening and resolved without treatment or with medication (corticosteroids). (bula de Trandolapril, Advertências)

  • TretinoínaretinoideGrave

    At first signs or symptoms of this syndrome, immediately initiate high-dose corticosteroid therapy and hemodynamic monitoring until resolution of signs and symptoms. (bula de Tretinoína, Advertência em caixa preta)

  • Trióxido de arsêniomedicamento que prolonga o intervalo QTGrave

    If differentiation syndrome is suspected, immediately initiate high-dose corticosteroids and hemodynamic monitoring until resolution. (bula de Trióxido de arsênio, Advertência em caixa preta)

  • Umeclidínio + vilanterolanticolinérgicoGrave

    • use of a long-acting beta 2 -adrenergic agonist (LABA), including vilanterol, one of the active ingredients in Umeclidinium and Vilanterol ELLIPTA, without an inhaled corticosteroid (ICS), in patients with asthma [see Warnings and Precautions ( 5.1 )] . (bula de Umeclidínio + vilanterol, Contraindicações)

  • UpadacitinibeimunossupressorGrave

    Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids. (bula de Upadacitinibe, Advertência em caixa preta)

Interações moderadas (199)

  • The chance is higher if you are age 60 or older take a blood thinning (anticoagulant) or steroid drug have 3 or more alcoholic drinks every day while using this product have had stomach ulcers or bleeding problems take more or for a longer time than directed take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others]… (bula de Ácido acetilsalicílico, Advertências)

  • Ácido mefenâmicoAINEModerada

    Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy, concomitant use of oral corticosteroids, anti-platelet drugs (such as aspirin), anticoagulants, or selective serotonin reuptake inhibitors (SSRIs), smoking, use of alcohol, older age, and poor general health status. (bula de Ácido mefenâmico, Advertências e precauções)

  • Ácido valproicoanticonvulsivanteModerada

    Oral Contraceptive Steroids Administration of a single-dose of ethinyloestradiol (50 mcg)/levonorgestrel (250 mcg) to 6 women on valproate (200 mg BID) therapy for 2 months did not reveal any pharmacokinetic interaction. (bula de Ácido valproico, Interações medicamentosas)

  • Ácido zoledrônicobisfosfonatoModerada

    A dental examination with appropriate preventive dentistry should be considered prior to treatment with bisphosphonates in patients with a history of concomitant risk factors (e.g., cancer, chemotherapy, angiogenesis inhibitors, radiotherapy, corticosteroids, poor oral hygiene, preexisting dental disease or infection, anemia, coagulopathy). (bula de Ácido zoledrônico, Advertências e precauções)

  • AclidínioanticolinérgicoModerada

    Sympathomimetics, Methylxanthines, Steroids In clinical studies, concurrent administration of aclidinium bromide and other drugs commonly used in the treatment of COPD including sympathomimetics (short-acting beta 2 agonists), methylxanthines, and oral and inhaled steroids showed no increases in adverse drug reactions. (bula de Aclidínio, Interações medicamentosas)

  • AfatinibeModerada

    Patients receiving concomitant corticosteroids, nonsteroidal anti-inflammatory drugs (NSAIDs) or anti-angiogenic agents, or patients with increasing age or who have an underlying history of gastrointestinal ulceration, underlying diverticular disease or bowel metastases may be at increased risk of perforation. (bula de Afatinibe, Advertências e precauções)

  • AlbendazolModerada

    Risk of Neurologic Symptoms: Neurocysticercosis patients may experience cerebral hypertensive episodes, seizures or focal neurologic deficits after initiation of therapy; begin appropriate steroid and anticonvulsant therapy. (bula de Albendazol, Advertências e precauções)

  • AlendronatobisfosfonatoModerada

    …osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (bula de Alendronato, Advertências e precauções)

  • AlentuzumabeimunossupressorModerada

    Institute appropriate medical management (e.g., glucocorticoids, epinephrine, meperidine) for infusion-related reactions as needed [see Dosage and Administration (2.2) ] . (bula de Alentuzumabe, Advertências e precauções)

  • Alisquirenoanti-hipertensivoModerada

    Patients who experience these effects, even without respiratory distress, require prolonged observation and appropriate monitoring measures since treatment with antihistamines and corticosteroids may not be sufficient to prevent respiratory involvement. (bula de Alisquireno, Advertências e precauções)

  • Alogliptina + metforminainibidor da DPP-4Moderada

    Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs and isoniazid Alogliptin Cytochrome (CYP) P450, CYP-Substrates or Inhibitors Clinical Impact: Insulin Secretagogues and Insulin Insulin and insulin secretagogues… (bula de Alogliptina + metformina, Interações medicamentosas)

  • AlpelisibeModerada

    If a SCAR is not confirmed, VIJOICE may require dose modifications, topical or systemic corticosteroids, or oral antihistamine treatment as described in Table 4 [see Dosage and Administration (2.5)] . (bula de Alpelisibe, Advertências e precauções)

  • AmiodaronaantiarrítmicoModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Anfotericina BantifúngicoModerada

    Corticosteroids and Corticotropin (ACTH) Concurrent use of corticosteroids and ACTH may potentiate hypokalemia, which could predispose the patient to cardiac dysfunction. (bula de Anfotericina B, Interações medicamentosas)

  • Atracúriobloqueador neuromuscularModerada

    Myopathy Patients receiving corticosteroids, including EMFLAZA, and concomitant therapy with neuromuscular blocking agents (e.g., pancuronium) or patients with disorders of neuromuscular transmission (e.g., myasthenia gravis) may be at increased risk of developing acute myopathy. (bula de Deflazacorte, Advertências e precauções)

  • BeclometasonacorticosteroideModerada

    Lung function (FEV 1 or PEF), beta‑agonist use, and asthma symptoms should be carefully monitored during withdrawal of oral or other systemic corticosteroids. (bula de Beclometasona, Advertências e precauções)

  • Beladona + ópioopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Beladona + ópio, Advertências e precauções)

  • BendamustinaModerada

    Consider measures to prevent severe reactions, including antihistamines, antipyretics and corticosteroids in subsequent cycles in patients who have experienced Grade 1 or 2 infusion reactions. (bula de Bendamustina, Advertências e precauções)

  • • Reduction in Corticosteroid Dosage: Do not discontinue systemic or inhaled corticosteroids abruptly upon initiation of therapy with FASENRA. (bula de Benralizumabe, Advertências e precauções)

  • Corticosteroids (systemic): cortisone/hydrocortisone dexamethasone ↑ corticosteroids (systemic) ↓ lenacapavir (dexamethasone) Concomitant administration with systemic corticosteroids whose exposures are significantly increased by CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression. (bula de Bictegravir + entricitabina + tenofovir alafenamida, Interações medicamentosas)

  • Budesonida + formoterolcorticosteroideModerada

    In this situation, the patient requires immediate re-evaluation with reassessment of the treatment regimen, giving special consideration to the possible need for replacing the current strength of budesonide and formoterol fumarate dihydrate with a higher strength, adding additional inhaled corticosteroid, or initiating systemic corticosteroids. (bula de Budesonida + formoterol, Advertências e precauções)

  • BuprenorfinaopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Buprenorfina, Advertências e precauções)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Buprenorfina + naloxona, Advertências e precauções)

  • BupropionaantidepressivoModerada

    …risk of seizure: concomitant use of other medications that lower the seizure threshold (e.g., other bupropion products, antipsychotics, tricyclic antidepressants, theophylline, and systemic corticosteroids), metabolic disorders (e.g., hypoglycemia, hyponatremia, severe hepatic impairment, and hypoxia), or use of illicit drugs (e.g., cocaine) or abuse or misuse… (bula de Bupropiona, Advertências e precauções)

  • In patients receiving concomitant corticosteroids and chronic use of aspirin, withdrawal of corticosteroids may result in salicylism because corticosteroids enhance renal clearance of salicylates and their withdrawal is followed by return to normal rates of renal clearance. (bula de Butalbital + ácido acetilsalicílico + cafeína, Interações medicamentosas)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Butalbital + ácido acetilsalicílico + cafeína + codeína, Advertências e precauções)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Butalbital + paracetamol + cafeína + codeína, Advertências e precauções)

  • ButorfanolopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Butorfanol, Advertências)

  • CefoxitinacefalosporinaModerada

    High concentrations of cefoxitin in the urine may interfere with measurement of urinary 17-hydroxy-corticosteroids by the Porter-Silber reaction, and produce false increases of modest degree in the levels reported. (bula de Cefoxitina, Advertências e precauções)

  • CelecoxibeAINEModerada

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs (such as aspirin), anticoagulants; or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (bula de Celecoxibe, Advertências e precauções)

  • CetoprofenoAINEModerada

    PRECAUTIONS General Ketoprofen Capsules, USP cannot be expected to substitute for corticosteroids or to treat corticosteroid insufficiency. (bula de Cetoprofeno, Advertências e precauções)

  • CetorolacoAINEModerada

    In addition to past history of ulcer disease, other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids, or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (bula de Cetorolaco, Advertências e precauções)

  • CiclosporinaimunossupressorModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Cimetidinabloqueador H2Moderada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • CiprofloxacinofluoroquinolonaModerada

    The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is increased in patients over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. (bula de Ciprofloxacino, Advertências e precauções)

  • Cisatracúriobloqueador neuromuscularModerada

    Myopathy Patients receiving corticosteroids, including EMFLAZA, and concomitant therapy with neuromuscular blocking agents (e.g., pancuronium) or patients with disorders of neuromuscular transmission (e.g., myasthenia gravis) may be at increased risk of developing acute myopathy. (bula de Deflazacorte, Advertências e precauções)

  • CitarabinaantimetabólitoModerada

    These reactions include reversible corneal toxicity, and hemorrhagic conjunctivitis, which may be prevented or diminished by prophylaxis with a local corticosteroid eye drop; cerebral and cerebellar dysfunction, including personality changes, somnolence and coma, usually reversible; severe gastrointestinal ulceration, including pneumatosis cystoides intestinalis… (bula de Citarabina, Advertências)

  • CladribinaantimetabólitoModerada

    Prevention or Management Consider a possible decrease in cladribine efficacy if potent BCRP (e.g., corticosteroids) or P-gp (e.g., rifampicin, St. (bula de Cladribina, Interações medicamentosas)

  • Claritromicinaantibiótico macrolídeoModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Cocaínaanestésico localModerada

    Plasma cholinesterase activity may be decreased by chronic administration of certain monoamine oxidase inhibitors, oral contraceptives, glucocorticoids, antimyasthenics (neostigmine), cyclophosphamide, and possibly thiotepa. (bula de Cocaína, Interações medicamentosas)

  • CodeínaopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Codeína, Advertências e precauções)

  • DaptomicinaantibióticoModerada

    Eosinophilic pneumonia: Discontinue Daptomycin for Injection and consider treatment with systemic steroids. (bula de Daptomicina, Advertências e precauções)

  • DarunavirantirretroviralModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Darunavir + cobicistateantirretroviralModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • DenosumabeModerada

    Other risk factors for the development of ONJ include immunosuppressive therapy, treatment with angiogenesis inhibitors, systemic corticosteroids, diabetes, and gingival infections. (bula de Denosumabe, Advertências e precauções)

  • Desogestrel + etinilestradiolanticoncepcional oralModerada

    Sex hormone binding globulins are increased and result in elevated levels of total circulating sex steroids however, free or biologically active levels either decrease or remain unchanged. e. (bula de Desogestrel + etinilestradiol, Precauções)

  • Diacetato de etinodiol + etinilestradiolanticoncepcional oralModerada

    The amount of both steroids should be considered in the choice of an oral contraceptive. (bula de Diacetato de etinodiol + etinilestradiol, Advertências)

  • DicicloverinaanticolinérgicoModerada

    Anticholinergic drugs in the presence of increased intraocular pressure may be hazardous when taken concurrently with agents such as corticosteroids. (bula de Dicicloverina, Interações medicamentosas)

  • DiclofenacoAINEModerada

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (bula de Diclofenaco, Advertências e precauções)

  • Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs (such as aspirin), anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (bula de Diclofenaco + misoprostol, Advertências e precauções)

  • DiflunisalAINEModerada

    Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (bula de Diflunisal, Advertências)

  • Digoxinaglicosídeo digitálicoModerada

    Serum potassium levels should be carefully monitored when digoxin is given to patients at high risk of hypokalemia ( e.g. , those receiving diuretics, corticosteroids, or other drugs that commonly lead to potassium loss; those with gastrointestinal losses through diarrhea, vomiting, or nasogastric suction; or those with potassium-losing endocrinopathies or nephropathies). (bula de Digoxina, Advertências e precauções)

  • Diltiazembloqueador dos canais de cálcioModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • DronedaronaantiarrítmicoModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • DupilumabeModerada

    Eosinophilic Conditions: Be alert to vasculitic rash, worsening pulmonary symptoms, cardiac complications, kidney injury and/or neuropathy, especially upon reduction of oral corticosteroids. (bula de Dupilumabe, Advertências e precauções)

  • Although other risk factors were present in some cases (such as corticosteroid use, exposure to radiation), a possible risk attributable to treatment with ivacaftor cannot be excluded. (bula de Elexacaftor + tezacaftor + ivacaftor, Advertências e precauções)

  • Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Eritromicinaantibiótico macrolídeoModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • ErlotinibeModerada

    Patients receiving concomitant anti-angiogenic agents, corticosteroids, NSAIDs, or taxane-based chemotherapy, or who have prior history of peptic ulceration or diverticular disease may be at increased risk of perforation [see Adverse Reactions (6.1 , 6.2) ]. (bula de Erlotinibe, Advertências e precauções)

  • EstradiolestrogênioModerada

    Other binding proteins may be elevated in serum (i.e., corticosteroid binding globulin (CBG), sex hormone binding globulin (SHBG)) leading to increased total circulating corticosteroids and sex steroids, respectively. (bula de Estradiol, Precauções)

  • Estradiol + dienogesteanticoncepcional oralModerada

    Interference with Laboratory Tests The use of contraceptive steroids may influence the results of certain laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins [see Warnings and Precautions ( 5.11 ) and Drug Interactions ( 7.2 )]. (bula de Estradiol + dienogeste, Interações medicamentosas)

  • Estradiol + noretisteronaestrogênioModerada

    Other binding proteins may be elevated in serum, for example, corticosteroid binding globulin (CBG), sex hormone-binding globulin (SHBG), leading to increased total circulating corticosteroids and sex steroids, respectively. (bula de Estradiol + noretisterona, Advertências e precauções)

  • Estrogênios conjugadosestrogênioModerada

    Other binding proteins may be elevated in serum, i.e., corticosteroid binding globulin (CBG), SHBG, leading to increased total circulating corticosteroids and sex steroids respectively. (bula de Estrogênios conjugados, Precauções)

  • Other binding proteins may be elevated in serum, for example, corticosteroid binding globulin (CBG), sex hormone-binding globulin (SHBG), leading to increased total circulating corticosteroids and sex steroids, respectively. (bula de Estrogênios conjugados + bazedoxifeno, Advertências e precauções)

  • EtodolacoAINEModerada

    Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (bula de Etodolaco, Advertências)

  • EverolimoimunossupressorModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Use of corticosteroids may cause a protein catabolic state and, thereby, potentially increase plasma ammonia levels in patients with impaired ability to form urea. (bula de Fenilacetato de sódio + benzoato de sódio, Interações medicamentosas)

  • Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Valproic Acid, Haloperidol, or Corticosteroids : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de sódio, Interações medicamentosas)

  • FenilefrinadescongestionanteModerada

    Agonistic Effects (increase in BIORPHEN blood pressure effect) can occur with monoamine oxidase inhibitors (MAOI), oxytocin and oxytocic drugs, tricyclic antidepressants, angiotensin and aldosterone, atropine, steroids, norepinephrine transporter inhibitors, ergot alkaloids. (bula de Fenilefrina, Interações medicamentosas)

  • FenoprofenoAINEModerada

    Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (bula de Fenoprofeno, Advertências e precauções)

  • FentanilaopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Fentanila, Advertências e precauções)

  • FingolimodeimunossupressorModerada

    In both cases, the patients were taking a 1.25 mg dose of fingolimod (higher than the recommended 0.5 mg dose) and had received high-dose corticosteroid therapy to treat suspected MS relapses. (bula de Fingolimode, Advertências e precauções)

  • Fluconazolantifúngico azólicoModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • FlunisolidacorticosteroideModerada

    Pregnancy As with other corticosteroids, flunisolide has been shown to be teratogenic and fetotoxic in rabbits and rats at oral doses of 40 and 200 mcg/kg/day, respectively (approximately 2 and 4 times, respectively, the maximum recommended daily intranasal dose in adults on a mg/m 2 basis). (bula de Flunisolida, Precauções)

  • FluocinonidacorticosteroideModerada

    Use of more than one corticosteroid-containing product at the same time may increase the total systemic absorption of topical corticosteroids. (bula de Fluocinonida, Advertências e precauções)

  • FlurbiprofenoAINEModerada

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking, use of alcohol, older age, and poor general health status. (bula de Flurbiprofeno, Advertências e precauções)

  • Fluticasona + salmeterolcorticosteroideModerada

    In this situation, the patient requires immediate reevaluation with reassessment of the treatment regimen, giving special consideration to the possible need for replacing the current strength of Fluticasone Propionate/Salmeterol MDPI with a higher strength, adding additional inhaled corticosteroid, or initiating systemic corticosteroids. (bula de Fluticasona + salmeterol, Advertências e precauções)

  • Fosaprepitantoinibidor da CYP3A4Moderada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • GlimepiridasulfonilureiaModerada

    …medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are… (bula de Glimepirida, Interações medicamentosas)

  • GlipizidasulfonilureiaModerada

    …examples of medication that may reduce the glucose-lowering effect of GLUCOTROL XL, leading to worsening glycemic control: atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin,… (bula de Glipizida, Interações medicamentosas)

  • HalobetasolcorticosteroideModerada

    Use of more than one corticosteroid-containing product at the same time may increase the total systemic exposure to topical corticosteroids. (bula de Halobetasol, Advertências e precauções)

  • HaloperidolantipsicóticoModerada

    Caution is advised when haloperidol decanoate is used in combination with drugs known to cause electrolyte imbalance (e.g., diuretics or corticosteroids) because hypokalemia, hypomagnesemia, and hypocalcemia are risk factors for QT prolongation. (bula de Haloperidol, Interações medicamentosas)

  • HidralazinavasodilatadorModerada

    Long-term treatment with steroids may be necessary (see PRECAUTIONS, Laboratory Tests ). (bula de Hidralazina, Advertências)

  • HidrocodonaopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Hidrocodona, Advertências e precauções)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Hidrocodona + clorfeniramina, Advertências e precauções)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Hidrocodona + homatropina, Advertências e precauções)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Hidrocodona + ibuprofeno, Advertências)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Hidrocodona + paracetamol, Advertências)

  • HidromorfonaopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Hidromorfona, Advertências e precauções)

  • IbandronatobisfosfonatoModerada

    …osteonecrosis of the jaw include invasive dental procedures (e.g., tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (e.g., chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (e.g., periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection, ill-fitting… (bula de Ibandronato, Advertências e precauções)

  • IbuprofenoAINEModerada

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (bula de Ibuprofeno, Advertências e precauções)

  • Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (bula de Ibuprofeno + famotidina, Advertências e precauções)

  • Imatinibeinibidor da CYP3A4Moderada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • IndometacinaAINEModerada

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (bula de Indometacina, Advertências e precauções)

  • Insulina asparteinsulinaModerada

    Drugs That May Decrease the Blood Glucose Lowering Effect of Insulin Aspart Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g.,… (bula de Insulina asparte, Interações medicamentosas)

  • Insulina degludecainsulinaModerada

    Drugs That May Decrease the Blood Glucose Lowering Effect of Insulin Degludec Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g.,… (bula de Insulina degludeca, Interações medicamentosas)

  • Insulina detemirinsulinaModerada

    Drugs That May Decrease the Blood Glucose Lowering Effect of LEVEMIR Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol,… (bula de Insulina detemir, Interações medicamentosas)

  • Insulina glarginainsulinaModerada

    Drugs that May Decrease the Blood Glucose Lowering Effect of Insulin Glargine-yfgn Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents… (bula de Insulina glargina, Interações medicamentosas)

  • Insulina lisproinsulinaModerada

    Drugs That May Decrease the Blood Glucose Lowering Effect of LYUMJEV Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol,… (bula de Insulina lispro, Interações medicamentosas)

  • IsoniazidaantibióticoModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Itraconazolantifúngico azólicoModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Ivacaftorinibidor da CYP3A4Moderada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • IvermectinaModerada

    Oral hydration, recumbency, intravenous normal saline, and/or parenteral corticosteroids have been used to treat postural hypotension. (bula de Ivermectina, Advertências)

  • LenacapavirantirretroviralModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • LevofloxacinofluoroquinolonaModerada

    The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is increased in patients usually over 60 years of age, in those taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. (bula de Levofloxacino, Advertências e precauções)

  • Levonorgestrel + etinilestradiolanticoncepcional oralModerada

    Thyroid Hormone Replacement Therapy or Corticosteroid Replacement Therapy Clinical effect Concomitant use of CHCs with thyroid hormone replacement therapy or corticosteroid replacement therapy may increase systemic exposure of thyroid-binding and cortisol-binding globulin [see Warnings and Precautions (5.11) ]. (bula de Levonorgestrel + etinilestradiol, Interações medicamentosas)

  • LevorfanolopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Levorfanol, Advertências)

  • Levossalbutamolagonista beta-adrenérgicoModerada

    If the patient needs more doses of XOPENEX HFA than usual, this may be a marker of destabilization of asthma and requires reevaluation of the patient and treatment regimen, giving special consideration to the possible need for anti-inflammatory treatment, e.g., corticosteroids. (bula de Levossalbutamol, Advertências e precauções)

  • Levotiroxinahormônio tireoidianoModerada

    When concomitant administration of corticosteroids and levothyroxine is required, administration of corticosteroid should precede the initiation of levothyroxine therapy to reduce the risk of adrenal crisis. (bula de Deflazacorte, Advertências e precauções)

  • Levotiroxina + liotironinahormônio tireoidianoModerada

    When concomitant administration of corticosteroids and levothyroxine is required, administration of corticosteroid should precede the initiation of levothyroxine therapy to reduce the risk of adrenal crisis. (bula de Deflazacorte, Advertências e precauções)

  • Liotironinahormônio tireoidianoModerada

    In addition, patients with hypopituitarism, primary adrenal insufficiency or congenital adrenal hyperplasia, altered thyroid function, or pheochromocytoma may be at increased risk for adverse endocrine events. (bula de Deflazacorte, Advertências e precauções)

  • Lisinopril + hidroclorotiazidainibidor da ECAModerada

    Even in those instances where swelling of only the tongue is involved, without respiratory distress, patients may require prolonged observation since treatment with antihistamines and corticosteroids may not be sufficient. (bula de Lisinopril + hidroclorotiazida, Advertências)

  • In patients who experience mild or moderate IRRs, consider premedications, including antihistamines, corticosteroids, and antipyretics. (bula de Margetuximabe, Advertências e precauções)

  • MedroxiprogesteronaprogestinaModerada

    MPA Injectable Suspension, USP can pose an additional risk in patients with risk factors for osteoporosis (e.g., metabolic bone disease, chronic alcohol and/or tobacco use, anorexia nervosa, strong family history of osteoporosis or chronic use of drugs that can reduce bone mass such as anticonvulsants or corticosteroids). (bula de Medroxiprogesterona, Advertências e precauções)

  • MegestrolprogestinaModerada

    Laboratory evaluation for adrenal insufficiency and consideration of replacement or stress doses of a rapidly acting glucocorticoid are strongly recommended in such patients. (bula de Megestrol, Advertências e precauções)

  • MeloxicamAINEModerada

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (bula de Meloxicam, Advertências e precauções)

  • MepolizumabeModerada

    Decrease corticosteroids gradually, if appropriate. (bula de Mepolizumabe, Advertências e precauções)

  • MetadonaopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Metadona, Advertências e precauções)

  • Metazolamidainibidor da anidrase carbônicaModerada

    Drug Interactions Methazolamide should be used with caution in patients on steroid therapy because of the potential for developing hypokalemia. (bula de Metazolamida, Interações medicamentosas)

  • Metildopaanti-hipertensivoModerada

    If not, corticosteroids may be given and other causes of anemia should be considered. (bula de Metildopa, Advertências)

  • MetiltestosteronaandrogênioModerada

    Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids. (bula de Metiltestosterona, Advertências)

  • MetiraponaModerada

    This can be corrected by giving appropriate doses of corticosteroids. (bula de Metirapona, Advertências e precauções)

  • Metolazonadiurético tiazídicoModerada

    Corticosteroids Or ACTH May increase the risk of hypokalemia and increase salt and water retention. (bula de Metolazona, Interações medicamentosas)

  • MetotrexatoimunossupressorModerada

    NSAIDs, Aspirin, and Steroids: May elevate and prolong serum methotrexate levels and increase gastrointestinal toxicity. (bula de Metotrexato, Interações medicamentosas)

  • Mirabegronaagonista beta-adrenérgicoModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • MometasonacorticosteroideModerada

    Lung function (FEV 1 or PEF), beta-agonist use, and asthma symptoms should be carefully monitored during withdrawal of oral or other systemic corticosteroids. (bula de Mometasona, Advertências e precauções)

  • Montelucasteantagonista do receptor de leucotrienosModerada

    Inhaled corticosteroid may be reduced gradually. (bula de Montelucaste, Advertências e precauções)

  • MorfinaopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Morfina, Advertências e precauções)

  • MoxifloxacinofluoroquinolonaModerada

    The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is increased in patients over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. (bula de Moxifloxacino, Advertências e precauções)

  • NabumetonaAINEModerada

    Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (bula de Nabumetona, Advertências)

  • NalbufinaopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Nalbufina, Advertências)

  • Naltrexona + bupropionaantagonista opioideModerada

    …hypoglycemia concomitant administration of medications that may lower the seizure threshold, including other bupropion products, antipsychotics, tricyclic antidepressants, theophylline, systemic steroids Recommendations for Reducing the Risk of Seizure: Clinical experience with bupropion suggests that the risk of seizure may be minimized by adhering to the recommended… (bula de Naltrexona + bupropiona, Advertências e precauções)

  • NaproxenoAINEModerada

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (bula de Naproxeno, Advertências e precauções)

  • Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (bula de Naproxeno + esomeprazol, Advertências e precauções)

  • NatalizumabeimunossupressorModerada

    In Studies MS1 and MS2, an increase in infections was seen in patients concurrently receiving short courses of corticosteroids. (bula de Natalizumabe, Advertências e precauções)

  • NateglinidameglitinidaModerada

    Drugs and Herbals That May Reduce the Blood-Glucose-Lowering Effect of Nateglinide and Increase Susceptibility to Hyperglycemia Drugs: Thiazides, corticosteroids, thyroid products, sympathomimetics, somatropin, somatostatin analogues (e.g., lanreotide, octreotide), and CYP inducers (e.g., rifampin, phenytoin and St John's Wort). (bula de Nateglinida, Interações medicamentosas)

  • NefazodonaantidepressivoModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • NintedanibeModerada

    Use OFEV with caution when treating patients with recent abdominal surgery, previous history of diverticular disease or receiving concomitant corticosteroids or NSAIDs. (bula de Nintedanibe, Advertências e precauções)

  • Nirmatrelvir + ritonavirantiviralModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • OcrelizumabeimunossupressorModerada

    In multiple sclerosis (MS) clinical trials, all adult and pediatric patients who were treated with OCREVUS received premedication with methylprednisolone (or an equivalent steroid), and may have also received an antihistamine (all pediatric patients) and/or an analgesic/antipyretic to reduce the risk of infusion reactions prior to each infusion. (bula de Ocrelizumabe, Advertências e precauções)

  • OfloxacinofluoroquinolonaModerada

    The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is increased in patients over 60 years of age, in those taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. (bula de Ofloxacino, Advertências)

  • OliceridinaopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Oliceridina, Advertências e precauções)

  • OmalizumabeModerada

    Corticosteroid Reduction: Do not abruptly discontinue corticosteroids upon initiation of OMLYCLO therapy. (bula de Omalizumabe, Advertências e precauções)

  • OxaprozinaAINEModerada

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs (such as aspirin), anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (bula de Oxaprozina, Advertências e precauções)

  • OxicodonaopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Oxicodona, Advertências e precauções)

  • If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Oxicodona + paracetamol, Advertências e precauções)

  • OximorfonaopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Oximorfona, Advertências e precauções)

  • Palbociclibeinibidor da CYP3A4Moderada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • PamidronatobisfosfonatoModerada

    Many of these patients were also receiving chemotherapy and corticosteroids, which may be risk factors for ONJ. (bula de Pamidronato, Advertências e precauções)

  • Paracetamol + codeínaopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Paracetamol + codeína, Advertências)

  • Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy, concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (bula de Paracetamol + ibuprofeno, Advertências e precauções)

  • PasireotidaModerada

    If adrenal insufficiency is suspected, it should be confirmed and treated per standard of care with exogenous glucocorticoids at replacement doses . (bula de Pasireotida, Advertências e precauções)

  • PenicilaminaModerada

    Treatment has consisted of high doses of corticosteroids alone or, in some cases, concomitantly with an immunosuppressant. (bula de Penicilamina, Advertências)

  • Pentazocina + naloxonaopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Pentazocina + naloxona, Advertências)

  • PerampanelanticonvulsivanteModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Petidina (meperidina)opioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Petidina (meperidina), Advertências e precauções)

  • Pioglitazona + glimepiridatiazolidinedionaModerada

    …medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are… (bula de Pioglitazona + glimepirida, Interações medicamentosas)

  • PiroxicamAINEModerada

    Other factors that increase the risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs (such as aspirin), anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (bula de Piroxicam, Advertências e precauções)

  • PonesimodeimunossupressorModerada

    Prior and Concomitant Treatment with Anti-neoplastic, Immune-Modulating, or Immunosuppressive Therapies Anti-neoplastic, immune-modulating, or immunosuppressive therapies (including corticosteroids) should be coadministered with caution because of the risk of additive immune system effects [see Drug Interactions (7.1) ] . (bula de Ponesimode, Advertências e precauções)

  • Posaconazolantifúngico azólicoModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Prometazina + codeínaopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Prometazina + codeína, Advertências e precauções)

  • Propiltiouracilamedicamento antitireoidianoModerada

    In addition, patients with hypopituitarism, primary adrenal insufficiency or congenital adrenal hyperplasia, altered thyroid function, or pheochromocytoma may be at increased risk for adverse endocrine events. (bula de Deflazacorte, Advertências e precauções)

  • Propofoldepressor do SNCModerada

    The following appear to be major risk factors for the development of these events: decreased oxygen delivery to tissues; serious neurological injury and/or sepsis; high dosages of one or more of the following pharmacological agents: vasoconstrictors, steroids, inotropes and/or prolonged, high-dose infusions of propofol (> 5 mg/kg/hour for > 48 hours). (bula de Propofol, Advertências e precauções)

  • Ranolazinamedicamento que prolonga o intervalo QTModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • RisedronatobisfosfonatoModerada

    …the jaw include invasive dental procedures (for example, tooth extraction, dental implants, boney surgery), diagnosis of cancer, concomitant therapies (for example, chemotherapy, corticosteroids, angiogenesis inhibitors), poor oral hygiene, and co-morbid disorders (for example, periodontal and/or other pre-existing dental disease, anemia, coagulopathy, infection,… (bula de Risedronato, Advertências e precauções)

  • Rocurôniobloqueador neuromuscularModerada

    Myopathy Patients receiving corticosteroids, including EMFLAZA, and concomitant therapy with neuromuscular blocking agents (e.g., pancuronium) or patients with disorders of neuromuscular transmission (e.g., myasthenia gravis) may be at increased risk of developing acute myopathy. (bula de Deflazacorte, Advertências e precauções)

  • Salbutamolagonista beta-adrenérgicoModerada

    If the patient needs more doses of Albuterol Sulfate HFA than usual, this may be a marker of destabilization of asthma and requires reevaluation of the patient and treatment regimen, giving special consideration to the possible need for anti-inflammatory treatment, e.g., corticosteroids. (bula de Salbutamol, Advertências e precauções)

  • SalsalatoAINEModerada

    Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (bula de Salsalato, Advertências)

  • SulindacoAINEModerada

    Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (bula de Sulindaco, Advertências)

  • Sumatriptana + naproxenotriptanoModerada

    Other factors that increase the risk for gastrointestinal bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status. (bula de Sumatriptana + naproxeno, Advertências e precauções)

  • Suvorexantosedativo-hipnóticoModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Suxametônio (succinilcolina)bloqueador neuromuscularModerada

    Myopathy Patients receiving corticosteroids, including EMFLAZA, and concomitant therapy with neuromuscular blocking agents (e.g., pancuronium) or patients with disorders of neuromuscular transmission (e.g., myasthenia gravis) may be at increased risk of developing acute myopathy. (bula de Deflazacorte, Advertências e precauções)

  • TapentadolopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Tapentadol, Advertências e precauções)

  • TemozolomidaModerada

    Pneumocystis Pneumonia (PCP) : Closely monitor all patients, particularly those receiving steroids, for the development of lymphopenia and PCP. (bula de Temozolomida, Advertências e precauções)

  • TensirolimoModerada

    If ILD is suspected, discontinue TORISEL, and consider use of corticosteroids and/or antibiotics. (bula de Tensirolimo, Advertências e precauções)

  • TeofilinametilxantinaModerada

    Dosage Increases: Increases in the dose of theophylline should not be made in response to an acute exacerbation of symptoms of chronic lung disease since theophylline provides little added benefit to inhaled beta2 -selective agonists and systemically administered corticosteroids in this circumstance and increases the risk of adverse effects. (bula de Teofilina, Advertências)

  • Terbutalinaagonista beta-adrenérgicoModerada

    If the patient needs more doses of terbutaline sulfate tablets than usual, this may be a marker of destabilization of asthma and requires reevaluation of the patient and the treatment regimen, giving special consideration to the possible need for anti-inflammatory treatment, e.g., corticosteroids. (bula de Terbutalina, Advertências)

  • Teriparatidahormônio tireoidianoModerada

    In addition, patients with hypopituitarism, primary adrenal insufficiency or congenital adrenal hyperplasia, altered thyroid function, or pheochromocytoma may be at increased risk for adverse endocrine events. (bula de Deflazacorte, Advertências e precauções)

  • Glucocorticoids : Patients receiving glucocorticoid replacement for previously diagnosed hypoadrenalism may require an increase in maintenance or stress doses following initiation of EGRIFTA SV. (bula de Tesamorrelina, Interações medicamentosas)

  • TestosteronaandrogênioModerada

    Abuse of Testosterone and Monitoring of Serum Testosterone : If testosterone use at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids is suspected, check serum testosterone concentration ( 5.5 ). (bula de Testosterona, Advertências e precauções)

  • Tiamazol (metimazol)medicamento antitireoidianoModerada

    In addition, patients with hypopituitarism, primary adrenal insufficiency or congenital adrenal hyperplasia, altered thyroid function, or pheochromocytoma may be at increased risk for adverse endocrine events. (bula de Deflazacorte, Advertências e precauções)

  • Ticagrelorantiagregante plaquetárioModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • TiotrópioanticolinérgicoModerada

    Concomitant Respiratory Medications SPIRIVA RESPIMAT has been used concomitantly with short-acting and long-acting sympathomimetic (beta-agonists) bronchodilators, methylxanthines, oral and inhaled steroids, antihistamines, mucolytics, leukotriene modifiers, cromones, and anti-IgE treatment without increases in adverse reactions. (bula de Tiotrópio, Interações medicamentosas)

  • TolmetinaAINEModerada

    Other factors that increase the risk for GI bleeding in patients treated with NSAIDs include concomitant use of oral corticosteroids or anticoagulants, longer duration of NSAID therapy, smoking, use of alcohol, older age, and poor general health status. (bula de Tolmetina, Advertências)

  • Toranja (grapefruit)Alimentos e bebidasModerada

    Therefore, give one third the recommended dosage of EMFLAZA when moderate or strong CYP3A4 inhibitors (e.g., clarithromycin, fluconazole, diltiazem, verapamil, grapefruit juice) are used concomitantly with EMFLAZA [see Dosage and Administration ( 2.5 ) and Clinical Pharmacology ( 12.3 )] . (bula de Deflazacorte, Interações medicamentosas)

  • Torasemidadiurético de alçaModerada

    Corticosteroids and ACTH: Increased risk of hypokalemia. (bula de Torasemida, Interações medicamentosas)

  • Toxina botulínica tipo Abloqueador neuromuscularModerada

    Myopathy Patients receiving corticosteroids, including EMFLAZA, and concomitant therapy with neuromuscular blocking agents (e.g., pancuronium) or patients with disorders of neuromuscular transmission (e.g., myasthenia gravis) may be at increased risk of developing acute myopathy. (bula de Deflazacorte, Advertências e precauções)

  • Toxina incobotulínica Abloqueador neuromuscularModerada

    Myopathy Patients receiving corticosteroids, including EMFLAZA, and concomitant therapy with neuromuscular blocking agents (e.g., pancuronium) or patients with disorders of neuromuscular transmission (e.g., myasthenia gravis) may be at increased risk of developing acute myopathy. (bula de Deflazacorte, Advertências e precauções)

  • Toxina onabotulínica Abloqueador neuromuscularModerada

    Myopathy Patients receiving corticosteroids, including EMFLAZA, and concomitant therapy with neuromuscular blocking agents (e.g., pancuronium) or patients with disorders of neuromuscular transmission (e.g., myasthenia gravis) may be at increased risk of developing acute myopathy. (bula de Deflazacorte, Advertências e precauções)

  • TramadolopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Tramadol, Advertências e precauções)

  • Tramadol + paracetamolopioideModerada

    If adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids. (bula de Tramadol + paracetamol, Advertências e precauções)

  • TrastuzumabeModerada

    Interrupt TRAZIMERA infusion in all patients experiencing dyspnea, clinically significant hypotension, and intervention of medical therapy administered (which may include epinephrine, corticosteroids, diphenhydramine, bronchodilators, and oxygen). (bula de Trastuzumabe, Advertências e precauções)

  • Triantereno + hidroclorotiazidadiurético poupador de potássioModerada

    Other Considerations Concurrent use of hydrochlorothiazide with amphotericin B or corticosteroids or corticotropin (ACTH) may intensify electrolyte imbalance, particularly hypokalemia, although the presence of triamterene minimizes the hypokalemic effect. (bula de Triantereno + hidroclorotiazida, Interações medicamentosas)

  • VarfarinaanticoagulanteModerada

    More frequent INR monitoring should be performed when starting or stopping other drugs, including botanicals, or when changing dosages of other drugs, including drugs intended for short-term use (e.g., antibiotics, antifungals, corticosteroids) [ see Boxed Warning ]. (bula de Varfarina, Interações medicamentosas)

  • Vecurôniobloqueador neuromuscularModerada

    Myopathy Patients receiving corticosteroids, including EMFLAZA, and concomitant therapy with neuromuscular blocking agents (e.g., pancuronium) or patients with disorders of neuromuscular transmission (e.g., myasthenia gravis) may be at increased risk of developing acute myopathy. (bula de Deflazacorte, Advertências e precauções)

  • Verapamilbloqueador dos canais de cálcioModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Voriconazolantifúngico azólicoModerada

    Moderate or strong CYP3A4 inhibitors: Give one third of the recommended dosage of EMFLAZA ( 7.1 ) (bula de Deflazacorte, Interações medicamentosas)

  • Prior to the first BIZENGRI infusion, premedicate with a corticosteroid, an H1 antihistamine and acetaminophen to reduce the risk of IRRs [see Dosage and Administration (2.4) ]. (bula de Zenocutuzumabe, Advertências e precauções)

Menções leves (74)

  • AcarboseantidiabéticoLeve

    These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel-blocking drugs, and isoniazid. (bula de Acarbose, Interações medicamentosas)

  • Ácido bempedoicoinibidor do OATP1B1Leve

    Tendon rupture may occur more frequently in patients over 60 years of age, in those taking corticosteroid or fluoroquinolone drugs, in patients with renal failure, and in patients with previous tendon disorders. (bula de Ácido bempedoico, Advertências e precauções)

  • Ácido etacrínicodiurético de alçaLeve

    Care should also be exercised in patients receiving potassium-depleting steroids. (bula de Ácido etacrínico, Advertências)

  • If signs of hypersensitivity occur, e.g. anaphylactoid reaction or angioedema develops, discontinue the Activase infusion and promptly institute appropriate therapy (e.g., antihistamines, intravenous corticosteroids, epinephrine). (bula de Alteplase, Advertências e precauções)

  • AmicacinaaminoglicosídeoLeve

    Most patients with hypersensitivity pneumonitis discontinued treatment with ARIKAYCE and received treatment with corticosteroids [see Adverse Reactions (6.1) ] . (bula de Amicacina, Advertências e precauções)

  • Ampicilinaantibiótico da classe das penicilinasLeve

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (bula de Ampicilina, Advertências)

  • Anfetaminaestimulante do SNCLeve

    Drug/Laboratory Test Interactions Amphetamines can cause a significant elevation in plasma corticosteroid levels. (bula de Anfetamina, Interações medicamentosas)

  • Anfetamina + dextroanfetaminaestimulante do SNCLeve

    Interference with Laboratory Tests Amphetamines can cause a significant elevation in plasma corticosteroid levels. (bula de Anfetamina + dextroanfetamina, Interações medicamentosas)

  • Benzilpenicilina (penicilina G)antibiótico da classe das penicilinasLeve

    Oxygen, intravenous steroids, and airway management, including intubation, should also be administered as indicated. (bula de Benzilpenicilina (penicilina G), Advertências)

  • Discontinue in patients who develop a severe infusion-related reaction and administer appropriate medical therapy (e.g., epinephrine, corticosteroids, intravenous antihistamines, bronchodilators and/or oxygen). (bula de Bevacizumabe, Advertências e precauções)

  • Corticosteroids, ACTH - Intensified electrolyte depletion, particularly hypokalemia. (bula de Bisoprolol + hidroclorotiazida, Precauções)

  • The administration of corticosteroids has been suggested, but the results have not been impressive or uniformly successful. (bula de Bussulfano, Advertências)

  • Calcitriolanálogo da vitamina DLeve

    Corticosteroids A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption. (bula de Calcitriol, Interações medicamentosas)

  • Some subjects in the EPIDIOLEX clinical trials had pruritus, erythema, and angioedema requiring treatment, including corticosteroids and antihistamines. (bula de Canabidiol (medicamento de prescrição), Advertências e precauções)

  • Candesartana + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Leve

    Steroids or Adrenocorticotropic Hormone – Hypokalemia may develop during concomitant use of steroids or adrenocorticotropic hormone (ACTH). (bula de Candesartana + hidroclorotiazida, Interações medicamentosas)

  • CefaclorcefalosporinaLeve

    SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. (bula de Cefaclor, Advertências)

  • CefadroxilacefalosporinaLeve

    SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. (bula de Cefadroxila, Advertências e precauções)

  • CefdinircefalosporinaLeve

    SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. (bula de Cefdinir, Advertências)

  • CefotetanacefalosporinaLeve

    SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. (bula de Cefotetana, Advertências)

  • CefprozilacefalosporinaLeve

    SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, INTRAVENOUS FLUIDS, INTRAVENOUS ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. (bula de Cefprozila, Advertências)

  • CeftazidimacefalosporinaLeve

    SERIOUS ACUTE HYPERSENSITIVITY REACTIONS MAY REQUIRE TREATMENT WITH EPINEPHRINE AND OTHER EMERGENCY MEASURES, INCLUDING OXYGEN, IV FLUIDS, IV ANTIHISTAMINES, CORTICOSTEROIDS, PRESSOR AMINES, AND AIRWAY MANAGEMENT, AS CLINICALLY INDICATED. (bula de Ceftazidima, Advertências)

  • CeftriaxonacefalosporinaLeve

    Serious acute hypersensitivity reactions may require treatment with epinephrine and other emergency measures including oxygen, corticosteroids, intravenous fluids, intravenous antihistamines, pressor amines, and airway management, as clinically indicated. (bula de Ceftriaxona, Advertências e precauções)

  • ClofarabinaantimetabólitoLeve

    The use of prophylactic steroids (e.g., 100 mg/m 2 hydrocortisone on Days 1 through 3) may be of benefit in preventing signs or symptoms of SIRS or capillary leak syndrome. (bula de Clofarabina, Advertências e precauções)

  • Clomifenomodulador seletivo do receptor de estrogênioLeve

    Elevated urinary steroid levels, varying degrees of electrolyte imbalance, hypovolemia, hemoconcentration, and hypoproteinemia may occur. (bula de Clomifeno, Advertências)

  • Clorotiazidadiurético tiazídicoLeve

    Corticosteroids, ACTH - intensified electrolyte depletion, particularly hypokalemia. (bula de Clorotiazida, Interações medicamentosas)

  • The recovery of the adrenal gland may take from days to months so patients should be protected from the stress (e.g., trauma or surgery) by the use of corticosteroids during the period of stress. (bula de Corticotropina, Advertências e precauções)

  • Dapagliflozina + metforminainibidor do SGLT2Leve

    These medications include thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (bula de Dapagliflozina + metformina, Interações medicamentosas)

  • Fluid retention events were typically managed by supportive care measures that may include diuretics or short courses of steroids. (bula de Dasatinibe, Advertências e precauções)

  • Dextroanfetaminaestimulante do SNCLeve

    Drug/Laboratory Test Interactions Amphetamines can cause a significant elevation in plasma corticosteroid levels. (bula de Dextroanfetamina, Interações medicamentosas)

  • Droperidolantagonista da dopaminaLeve

    These would include diuretics, laxatives and supraphysiological use of steroid hormones with mineralocorticoid potential. (bula de Droperidol, Interações medicamentosas)

  • Drospirenona + etinilestradiolanticoncepcional oralLeve

    Steroid hormones may be poorly metabolized in patients with impaired liver function. (bula de Drospirenona + etinilestradiol, Advertências e precauções)

  • Empagliflozina + metforminainibidor do SGLT2Leve

    These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (bula de Empagliflozina + metformina, Interações medicamentosas)

  • Corticosteroids, ACTH Intensified electrolyte depletion, particularly hypokalemia. (bula de Enalapril + hidroclorotiazida, Interações medicamentosas)

  • Espironolactona + hidroclorotiazidaantagonista da aldosteronaLeve

    Corticosteroids, ACTH: Intensified electrolyte depletion, particularly hypokalemia, may occur. (bula de Espironolactona + hidroclorotiazida, Interações medicamentosas)

  • Interference with Laboratory Tests The use of contraceptive steroids may influence the results of certain laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins. (bula de Etonogestrel + etinilestradiol, Interações medicamentosas)

  • Fenoximetilpenicilina (penicilina V)antibiótico da classe das penicilinasLeve

    OXYGEN, INTRAVENOUS STEROIDS, AND AIRWAY MANAGEMENT, INCLUDING INTUBATION, SHOULD ALSO BE ADMINISTERED AS INDICATED. (bula de Fenoximetilpenicilina (penicilina V), Advertências)

  • FludarabinaantimetabólitoLeve

    Steroids may or may not be effective in controlling these hemolytic episodes. (bula de Fludarabina, Advertências e precauções)

  • FluoxetinaISRSLeve

    Most patients improved promptly with discontinuation of fluoxetine and/or adjunctive treatment with antihistamines or steroids, and all patients experiencing these reactions were reported to recover completely. (bula de Fluoxetina, Advertências e precauções)

  • GlibenclamidasulfonilureiaLeve

    These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (bula de Glibenclamida, Interações medicamentosas)

  • Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (bula de Glibenclamida + metformina, Interações medicamentosas)

  • Glipizida + metforminasulfonilureiaLeve

    These drugs include thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (bula de Glipizida + metformina, Precauções)

  • In the reported cases NME resolved with discontinuation of the glucagon, and treatment with corticosteroids was not effective. (bula de Glucagon, Advertências e precauções)

  • GuselcumabeimunossupressorLeve

    TREMFYA was subsequently discontinued, and the liver test abnormalities resolved following administration of corticosteroids [see Adverse Reactions (6.1) ] . (bula de Guselcumabe, Advertências e precauções)

  • Atypical Antipsychotics (e.g., olanzapine and clozapine), Corticosteroids, Danazol, Diuretics, Estrogens, Glucagon, Isoniazid, Niacin, Oral Contraceptives, Phenothiazines, Progestogens (e.g., in oral contraceptives), Protease inhibitors, Somatropin, Sympathomimetic Agents (e.g., albuterol, epinephrine, terbutaline) and Thyroid Hormones. (bula de Insulina regular (humana), Interações medicamentosas)

  • IpratrópioanticolinérgicoLeve

    ATROVENT HFA has been used concomitantly with other drugs, including sympathomimetic bronchodilators, methylxanthines, oral and inhaled steroids commonly used in the treatment of COPD. (bula de Ipratrópio, Interações medicamentosas)

  • Patients with Grade 1 and 2 TFR may also be treated with corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDs) and/or narcotic analgesics for management of TFR symptoms. (bula de Lenalidomida, Advertências e precauções)

  • Linagliptina + metforminainibidor da DPP-4Leve

    These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (bula de Linagliptina + metformina, Interações medicamentosas)

  • The infusion should be terminated immediately, followed by the administration of volume expanders, pressor agents, corticosteroids, or antihistamines at the discretion of the physician. (bula de Melfalana, Advertências)

  • Metanfetaminaestimulante do SNCLeve

    Drug/Laboratory Test Interactions Amphetamines can cause a significant elevation in plasma corticosteroid levels. (bula de Metanfetamina, Interações medicamentosas)

  • MetforminabiguanidaLeve

    Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (bula de Metformina, Interações medicamentosas)

  • MetoexitalbarbitúricoLeve

    Intra-arterial glucocorticoid injection at the site of injury, followed by systemic steroids. (bula de Metoexital, Advertências)

  • Midodrinaagonista alfa-adrenérgicoLeve

    Midodrine hydrochloride has been used in patients concomitantly treated with salt-retaining steroid therapy (i.e., fludrocortisone acetate), with or without salt supplementation. (bula de Midodrina, Interações medicamentosas)

  • Following concurrent administration of mitoxantrone injection with corticosteroids, no evidence of drug interactions has been observed. (bula de Mitoxantrona, Interações medicamentosas)

  • Naltrexonaantagonista opioideLeve

    Both cases required hospitalization, and resolved after treatment with antibiotics and corticosteroids. (bula de Naltrexona, Advertências e precauções)

  • Interference with Laboratory Tests The use of contraceptive steroids may influence the results of certain laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins. (bula de Norelgestromina + etinilestradiol, Interações medicamentosas)

  • Noretisterona + etinilestradiolanticoncepcional oralLeve

    Steroid hormones may be poorly metabolized in patients with impaired liver function. (bula de Noretisterona + etinilestradiol, Advertências e precauções)

  • Norgestimato + etinilestradiolanticoncepcional oralLeve

    Interactions with Laboratory Tests The use of contraceptive steroids may influence the results of certain laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins. (bula de Norgestimato + etinilestradiol, Interações medicamentosas)

  • Norgestrel + etinilestradiolanticoncepcional oralLeve

    Interference with Laboratory Tests The use of contraceptive steroids may influence the results of certain laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins. (bula de Norgestrel + etinilestradiol, Precauções)

  • Olanzapina + fluoxetinaantipsicóticoLeve

    Most patients improved promptly with discontinuation of fluoxetine and/or adjunctive treatment with antihistamines or steroids, and all patients experiencing these reactions were reported to recover completely. (bula de Olanzapina + fluoxetina, Advertências e precauções)

  • Olmesartana + anlodipino + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Leve

    Corticosteroids, ACTH: Intensified electrolyte depletion, particularly hypokalemia. (bula de Olmesartana + anlodipino + hidroclorotiazida, Interações medicamentosas)

  • Olmesartana + hidroclorotiazidabloqueador do receptor da angiotensina II (BRA)Leve

    Corticosteroids, ACTH: Intensified electrolyte depletion, particularly hypokalemia. (bula de Olmesartana + hidroclorotiazida, Interações medicamentosas)

  • Oxacilinaantibiótico da classe das penicilinasLeve

    If an allergic reaction occurs, the drug should be discontinued and the patient should receive supportive treatment, e.g. , artificial maintenance of ventilation, pressor amines, antihistamines, and corticosteroids. (bula de Oxacilina, Advertências)

  • Pioglitazona + metforminatiazolidinedionaLeve

    These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (bula de Pioglitazona + metformina, Interações medicamentosas)

  • QuininaantimaláricoLeve

    Drug/Laboratory Interactions Quinine may produce an elevated value for urinary 17-ketogenic steroids when the Zimmerman method is used. (bula de Quinina, Interações medicamentosas)

  • Raloxifenomodulador seletivo do receptor de estrogênioLeve

    Other Concomitant Medications EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology ( 12.3 )] . (bula de Raloxifeno, Interações medicamentosas)

  • RepaglinidameglitinidaLeve

    Examples: Atypical antipsychotics (e.g., olanzapine and clozapine), calcium channel antagonists, corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and… (bula de Repaglinida, Interações medicamentosas)

  • RituximabeimunossupressorLeve

    Institute medical management (e.g., glucocorticoids, epinephrine, bronchodilators, or oxygen) for infusion-related reactions as needed. (bula de Rituximabe, Advertências e precauções)

  • Saxagliptina + metforminainibidor da DPP-4Leve

    These medications include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. (bula de Saxagliptina + metformina, Interações medicamentosas)

  • Sitagliptina + metforminainibidor da DPP-4Leve

    Examples: Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blockers, and isoniazid. (bula de Sitagliptina + metformina, Interações medicamentosas)

  • If symptoms of hypersensitivity occur, initiate appropriate therapy (e.g., antihistamines, corticosteroids, epinephrine). (bula de Tenecteplase, Advertências e precauções)

  • TobramicinaaminoglicosídeoLeve

    In clinical studies, patients receiving TOBI Podhaler continued to take dornase alfa, bronchodilators, inhaled corticosteroids, and macrolides. (bula de Tobramicina, Interações medicamentosas)

  • UstequinumabeimunossupressorLeve

    Patients improved with discontinuation of therapy and in certain cases administration of corticosteroids. (bula de Ustequinumabe, Advertências e precauções)

  • Vitamina DVitaminas e mineraisLeve

    Corticosteroides como a prednisona reduzem a absorção de cálcio e prejudicam o metabolismo da vitamina D, contribuindo para a perda óssea. (NIH Office of Dietary Supplements, Vitamin D)

  • ZiprasidonaantipsicóticoLeve

    Most patients improved promptly with adjunctive treatment with antihistamines or steroids and/or upon discontinuation of ziprasidone, and all patients experiencing these reactions were reported to recover completely. (bula de Ziprasidona, Advertências e precauções)

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Não é aconselhamento médico. A gravidade reflete a redação da bula, não as suas circunstâncias. Um alerta “grave” pode ser rotina sob supervisão, e um “leve” pode ser importante em doses altas. Pergunte a um farmacêutico.