Interaction Checker

Interações de Fenilbutirato de glicerol

Fenilbutirato de glicerol (Ravicti) tem 64 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 0; moderadas: 30; leves: 34; casos em que uma bula relata não haver interação significativa: 0). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.

Interações segundo a bula

Interações moderadas (30)

  • Ácido valproicoanticonvulsivanteModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Azelastina + fluticasonaanti-histamínicoModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • BeclometasonacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • BetametasonacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • BudesonidacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Budesonida + formoterolcorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • CiclesonidacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • CiclosporinaimunossupressorModerada

    CYP3A4 Substrates with narrow therapeutic index (e.g., alfentanil, quinidine, cyclosporine) : Glycerol phenylbutyrate may decrease exposure; monitor for decreased efficacy of the narrow therapeutic index drug ( 7.3 ) (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • ClobetasolcorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • DeflazacortecorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • DesonidacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • DexametasonacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Dextrometorfano + quinidinamedicamento serotoninérgicoModerada

    CYP3A4 Substrates with narrow therapeutic index (e.g., alfentanil, quinidine, cyclosporine) : Glycerol phenylbutyrate may decrease exposure; monitor for decreased efficacy of the narrow therapeutic index drug ( 7.3 ) (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Fenilacetato de sódio + benzoato de sódioModerada

    In a study of adult cancer patients, subjects received sodium phenylacetate administered as a 1-hour infusion twice daily at two dose levels of 125 and 150 mg/kg for a 2-week period. (bula de Fenilbutirato de glicerol, Advertências e precauções)

  • FludrocortisonacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • FlunisolidacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • FluocinonidacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • FluticasonacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Fluticasona + salmeterolcorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • HalobetasolcorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • HaloperidolantipsicóticoModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • HidrocortisonacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • MetilprednisolonacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • MidazolambenzodiazepínicoModerada

    Midazolam : Decreased exposure; monitor for suboptimal effect of midazolam.( 7.3 ) (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • MometasonacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Olopatadina + mometasonaanti-histamínicoModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • PrednisolonacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • PrednisonacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • QuinidinaantiarrítmicoModerada

    CYP3A4 Substrates with narrow therapeutic index (e.g., alfentanil, quinidine, cyclosporine) : Glycerol phenylbutyrate may decrease exposure; monitor for decreased efficacy of the narrow therapeutic index drug ( 7.3 ) (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • TriancinolonacorticosteroideModerada

    Corticosteroids, valproic acid, or haloperidol : May increase plasma ammonia level; monitor ammonia levels closely. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

Menções leves (34)

  • Aprepitantoinibidor da CYP3A4Leve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Armodafinilaestimulante do SNCLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Bosentanaindutor da CYP3A4Leve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • CarbamazepinaanticonvulsivanteLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • CenobamatoanticonvulsivanteLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • ClobazambenzodiazepínicoLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Deferasiroxsuplemento de ferroLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • EfavirenzantirretroviralLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Efavirenz + lamivudina + tenofovirantirretroviralLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • EslicarbazepinaanticonvulsivanteLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • EtravirinaantirretroviralLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Fenilbutirato de sódioLeve

    In clinical trials in patients with UCDs who had been on sodium phenylbutyrate prior to administration of glycerol phenylbutyrate, adverse reactions of headache, fatigue, symptoms of peripheral neuropathy, seizures, tremor and/or dizziness were reported. (bula de Fenilbutirato de glicerol, Advertências e precauções)

  • FenitoínaanticonvulsivanteLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • FenobarbitalbarbitúricoLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Fentermina + topiramatoestimulante do SNCLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • FosfenitoínaanticonvulsivanteLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • GriseofulvinaantifúngicoLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Lopinavir + ritonavirantirretroviralLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Lorlatinibeindutor da CYP3A4Leve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Mitapivateindutor da CYP3A4Leve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Mitotanoindutor da CYP3A4Leve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Modafinilaestimulante do SNCLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Nafcilinaantibiótico da classe das penicilinasLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • NevirapinaantirretroviralLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • OxcarbazepinaanticonvulsivanteLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • PrimidonaanticonvulsivanteLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • ProbenecidaLeve

    Probenecid : May affect renal excretion of metabolites of glycerol phenylbutyrate, including phenylacetylglutamine (PAGN) and PAA. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Probenecida + colchicinaLeve

    Probenecid : May affect renal excretion of metabolites of glycerol phenylbutyrate, including phenylacetylglutamine (PAGN) and PAA. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • RifabutinaantibióticoLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • RifampicinaantibióticoLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • RifapentinaantibióticoLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • RitonavirantirretroviralLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • Suzetriginaindutor da CYP3A4Leve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

  • TopiramatoanticonvulsivanteLeve

    Potential for Glycerol Phenylbutyrate to Affect Other Drugs Drugs with narrow therapeutic index that are substrates of CYP3A4 Glycerol phenylbutyrate is a weak inducer of CYP3A4 in humans. (bula de Fenilbutirato de glicerol, Interações medicamentosas)

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Não é aconselhamento médico. A gravidade reflete a redação da bula, não as suas circunstâncias. Um alerta “grave” pode ser rotina sob supervisão, e um “leve” pode ser importante em doses altas. Pergunte a um farmacêutico.