Interações de Nizatidina

Nizatidina (Axid), bloqueador H2, tem 67 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 7; moderadas: 32; leves: 9; casos em que uma bula relata não haver interação significativa: 19). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.

Interações segundo a bula

Interações graves (7)

  • • Gastric Acid Reducing Agents: Avoid co-administration with proton pump inhibitors (PPIs). (bula de Acalabrutinibe, Interações medicamentosas)

  • Use of RPV with proton pump inhibitors is contraindicated and use of RPV with H 2 -receptor antagonists requires staggered administration [see Contraindications (4) and Clinical Pharmacology (12.3) ] . (bula de Entricitabina + rilpivirina + tenofovir, Interações medicamentosas)

  • Famotidinabloqueador H2Grave

    Famotidine Injection is contraindicated in patients with a history of serious hypersensitivity reactions (e.g., anaphylaxis) to famotidine or other H 2 -receptor antagonists. (bula de Famotidina, Contraindicações)

  • Ibuprofen and famotidine tablet should not be administered to patients with a history of hypersensitivity to other H 2 -receptor antagonists. (bula de Ibuprofeno + famotidina, Contraindicações)

  • Metilfenidatoestimulante do SNCGrave

    Intervention Concomitant use of methylphenidate extended-release orally disintegrating tablets with a gastric pH modulator (i.e., a H2-blocker or a proton pump inhibitor) is not recommended. (bula de Metilfenidato, Interações medicamentosas)

  • Concomitant Use With Gastric Acid-Reducing Agents : Avoid concomitant use of VOTRIENT with gastric acid-reducing agents. (bula de Pazopanibe, Interações medicamentosas)

  • RisedronatobisfosfonatoGrave

    Concomitant administration of Risedronate sodium delayed-release and H 2 blockers or PPIs is not recommended. (bula de Risedronato, Interações medicamentosas)

Interações moderadas (32)

  • In patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently. (bula de Nizatidina, Interações medicamentosas)

  • Ácido acetilsalicílico + dipiridamolantiagregante plaquetárioModerada

    In patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently. (bula de Nizatidina, Interações medicamentosas)

  • AtazanavirantirretroviralModerada

    Reduced plasma concentrations of atazanavir are expected if proton-pump inhibitors, antacids, buffered medications, or H 2 -receptor antagonists are administered with REYATAZ [see Dosage and Administration ( 2.3 , 2.4 , 2.5 and 2.6) ] . (bula de Atazanavir, Interações medicamentosas)

  • BalsalazidasalicilatoModerada

    In patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently. (bula de Nizatidina, Interações medicamentosas)

  • BosutinibeModerada

    Proton Pump Inhibitors (PPI) As an alternative to PPIs, use short-acting antacids or H2 blockers and separate dosing by more than 2 hours from BOSULIF dosing. (bula de Bosutinibe, Interações medicamentosas)

  • In patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently. (bula de Nizatidina, Interações medicamentosas)

  • In patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently. (bula de Nizatidina, Interações medicamentosas)

  • CefpodoximacefalosporinaModerada

    Drug Interactions Antacids Concomitant administration of high doses of antacids (sodium bicarbonate and aluminum hydroxide) or H 2 blockers reduces peak plasma levels by 24% to 42% and the extent of absorption by 27% to 32%, respectively. (bula de Cefpodoxima, Interações medicamentosas)

  • Cetoconazolantifúngico azólicoModerada

    Drugs that may decrease ketoconazole plasma concentrations Drugs that reduce the gastric acidity (e.g., acid neutralizing medicines such as aluminum hydroxide, or acid secretion suppressors such as H 2 -receptor antagonists and proton pump inhibitors) impair the absorption of ketoconazole from ketoconazole tablets. (bula de Cetoconazol, Interações medicamentosas)

  • DiflunisalAINEModerada

    In patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently. (bula de Nizatidina, Interações medicamentosas)

  • ErlotinibeModerada

    Drugs the Increase Gastric pH Co-administration of erlotinib with proton pump inhibitors (e.g., omeprazole) and H-2 receptor antagonists (e.g., ranitidine) decreased erlotinib exposure [see Clinical Pharmacology (12.3) ]. (bula de Erlotinibe, Interações medicamentosas)

  • FenitoínaanticonvulsivanteModerada

    …Azoles Fluconazole, ketoconazole, itraconazole, miconazole, voriconazole Antineoplastic agents Capecitabine, fluorouracil Antidepressants Fluoxetine, fluvoxamine, sertraline Gastric acid reducing agents H 2 antagonists (cimetidine), omeprazole Sulfonamides Sulfamethizole, sulfaphenazole, sulfadiazine, sulfamethoxazole-trimethoprim Other Acute alcohol intake, amiodarone,… (bula de Fenitoína, Interações medicamentosas)

  • FosamprenavirantirretroviralModerada

    Histamine H 2 -receptor antagonists: Cimetidine, famotidine, nizatidine, ranitidine a Fosamprenavir calcium: ↓ Amprenavir Fosamprenavir calcium/ritonavir: Interaction not evaluated Use with caution. (bula de Fosamprenavir, Interações medicamentosas)

  • FosfenitoínaanticonvulsivanteModerada

    …Azoles Fluconazole, ketoconazole, itraconazole, miconazole, voriconazole Antineoplastic agents Capecitabine, fluorouracil Antidepressants Fluoxetine, fluvoxamine, sertraline Gastric acid reducing agents H 2 antagonists (cimetidine), omeprazole Sulfonamides Sulfamethizole, sulfaphenazole, sulfadiazine, sulfamethoxazole-trimethoprim Other Acute alcohol intake, amiodarone,… (bula de Fosfenitoína, Interações medicamentosas)

  • GefitinibeModerada

    Drugs Affecting Gastric pH Drugs that elevate gastric pH (e.g., proton pump inhibitors, histamine H 2 -receptor antagonists, and antacids) may reduce plasma concentrations of gefitinib. (bula de Gefitinibe, Interações medicamentosas)

  • GlimepiridasulfonilureiaModerada

    …glimepiride, increasing the susceptibility to and/or intensity of hypoglycemia: oral anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone,… (bula de Glimepirida, Interações medicamentosas)

  • GlipizidasulfonilureiaModerada

    …angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, propoxyphene, salicylates, somatostatin analogs (e.g., octreotide), sulfonamide antibiotics, nonsteroidal anti-inflammatory agents, chloramphenicol, probenecid, coumarins, voriconazole, H2 receptor antagonists, and quinolones. (bula de Glipizida, Interações medicamentosas)

  • IbandronatobisfosfonatoModerada

    H2 Blockers In healthy volunteers, co-administration with ranitidine resulted in a 20% increased bioavailability of ibandronate, which was not considered to be clinically relevant (see CLINICAL PHARMACOLOGY [12.3] ) . (bula de Ibandronato, Interações medicamentosas)

  • Itraconazolantifúngico azólicoModerada

    Gastrointestinal Drugs Drugs that reduce gastric acidity e.g. acid neutralizing medicines such as aluminum hydroxide, or acid secretion suppressors such as H 2 - receptor antagonists and proton pump inhibitors (e.g., omeprazole). (bula de Itraconazol, Interações medicamentosas)

  • Ledipasvir + sofosbuvirantiviralModerada

    Concomitant Drug Class: Drug Name Effect on Concentration ↓ = decrease, ↑ = increase Clinical Comment tenofovir DF = tenofovir disoproxil fumarate Acid Reducing Agents: ↓ ledipasvir Ledipasvir solubility decreases as pH increases. (bula de Ledipasvir + sofosbuvir, Interações medicamentosas)

  • In patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently. (bula de Nizatidina, Interações medicamentosas)

  • MesalazinasalicilatoModerada

    In patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently. (bula de Nizatidina, Interações medicamentosas)

  • Anaphylactic Shock and Hypersensitivity Reactions: Premedicate all patients with a combination of an H1-antihistamine, an H2 blocker, and a leukotriene inhibitor prior to each APHEXDA dose. (bula de Motixafortida, Advertências e precauções)

  • OctreotidaModerada

    Proton Pump Inhibitors, H2-receptor Antagonists, or Antacids: may decrease bioavailability of MYCAPSSA and the MYCAPSSA dose may need to be increased (‎ 7 ). (bula de Octreotida, Interações medicamentosas)

  • In patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently. (bula de Nizatidina, Interações medicamentosas)

  • Pioglitazona + glimepiridatiazolidinedionaModerada

    …tablets, increasing the susceptibility to and/or intensity of hypoglycemia: oral anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone,… (bula de Pioglitazona + glimepirida, Interações medicamentosas)

  • RilpivirinaantirretroviralModerada

    H 2 -Receptor Antagonists: cimetidine famotidine nizatidine ranitidine ↔ rilpivirine (famotidine taken 12 hours before rilpivirine or 4 hours after rilpivirine) The combination of EDURANT or EDURANT PED and H 2 -receptor antagonists should be used with caution as coadministration may cause significant decreases in rilpivirine plasma concentrations (increase in… (bula de Rilpivirina, Interações medicamentosas)

  • SalsalatoAINEModerada

    In patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently. (bula de Nizatidina, Interações medicamentosas)

  • Sofosbuvir + velpatasvirantiviralModerada

    Clinical Effect/Recommendation Acid Reducing Agents: ↓ velpatasvir Velpatasvir solubility decreases as pH increases. (bula de Sofosbuvir + velpatasvir, Interações medicamentosas)

  • Subsalicilato de bismutosalicilatoModerada

    In patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently. (bula de Nizatidina, Interações medicamentosas)

  • SulfassalazinasulfonamidaModerada

    In patients given very high doses (3,900 mg) of aspirin daily, increases in serum salicylate levels were seen when nizatidine, 150 mg b.i.d., was administered concurrently. (bula de Nizatidina, Interações medicamentosas)

  • TensirolimoModerada

    …physician, treatment may be resumed with the administration of an H 1 -receptor antagonist (such as diphenhydramine), if not previously administered [see Dosage and Administration (2.2) ] , and/or an H 2 -receptor antagonist (such as intravenous famotidine 20 mg or intravenous ranitidine 50 mg) approximately 30 minutes before restarting the TORISEL infusion. (bula de Tensirolimo, Advertências e precauções)

Menções leves (9)

  • CefaclorcefalosporinaLeve

    Drug Interactions Antacids The extent of absorption of cefaclor extended-release tablets is diminished if magnesium or aluminum hydroxide-containing antacids are taken within 1 hour of administration; H 2 blockers do not alter either the rate or the extent of absorption of cefaclor extended-release tablets. (bula de Cefaclor, Interações medicamentosas)

  • Darunavir + cobicistateantirretroviralLeve

    …drug-drug interactions have not been observed or are not anticipated with concomitant use of darunavir and cobicistat with rilpivirine, dolutegravir, raltegravir, abacavir, emtricitabine, emtricitabine/tenofovir alafenamide, tenofovir DF, lamivudine, stavudine, zidovudine, or acid modifying medications (antacids, H 2 -receptor antagonists, proton pump inhibitors). (bula de Darunavir + cobicistate, Interações medicamentosas)

  • FerroVitaminas e mineraisLeve

    Os medicamentos que reduzem a acidez diminuem o ácido do estômago e podem reduzir a quantidade de ferro absorvida de suplementos e alimentos. (NIH Office of Dietary Supplements, Iron)

  • Lapatinibeinibidor da glicoproteína PLeve

    Acid-Reducing Agents The aqueous solubility of lapatinib is pH dependent, with higher pH resulting in lower solubility. (bula de Lapatinibe, Interações medicamentosas)

  • MidazolambenzodiazepínicoLeve

    No change in choice reaction time or sedation index was detected after dosing with the H2 receptor antagonists. (bula de Midazolam, Interações medicamentosas)

  • Moexiprilinibidor da ECALeve

    Moexipril hydrochloride has been used in clinical trials concomitantly with calcium-channel-blocking agents, diuretics, H 2 blockers, digoxin, oral hypoglycemic agents, and cholesterol-lowering agents. (bula de Moexipril, Interações medicamentosas)

  • Nisoldipinobloqueador dos canais de cálcio di-hidropiridínicoLeve

    No pharmacodynamic effects of either histamine H 2 receptor antagonist were observed. (bula de Nisoldipino, Interações medicamentosas)

  • Prasugrelantiagregante plaquetárioLeve

    Effient can be administered with aspirin (75 mg to 325 mg per day), heparin, GPIIb/IIIa inhibitors, statins, digoxin, and drugs that elevate gastric pH, including proton pump inhibitors and H 2 blockers [see Clinical Pharmacology (12.3) ] . (bula de Prasugrel, Interações medicamentosas)

  • Vitamina B12Vitaminas e mineraisLeve

    A terapia prolongada de redução da acidez interfere na absorção da B12 dos alimentos e pode levar a deficiência. (NIH Office of Dietary Supplements, Vitamin B12)

Nenhuma interação significativa relatada (19)

  • Alopurinolinibidor da xantina oxidaseSem interação

    Drug Interactions No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. (bula de Nizatidina, Interações medicamentosas)

  • Alvimopanantagonista opioideSem interação

    Effects of Concomitant Acid Blockers or Antibiotics A population pharmacokinetic analysis suggests that the pharmacokinetics of alvimopan were not affected by concomitant administration of acid blockers (proton pump inhibitors (PPIs), histamine-2 (H 2 ) receptor antagonists) or antibiotics. (bula de Alvimopan, Interações medicamentosas)

  • AminofilinametilxantinaSem interação

    Drug Interactions No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. (bula de Nizatidina, Interações medicamentosas)

  • Butalbital + paracetamol + cafeínabarbitúricoSem interação

    Drug Interactions No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. (bula de Nizatidina, Interações medicamentosas)

  • Drug Interactions No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. (bula de Nizatidina, Interações medicamentosas)

  • ClordiazepóxidobenzodiazepínicoSem interação

    Drug Interactions No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. (bula de Nizatidina, Interações medicamentosas)

  • Clordiazepóxido + clidíniobenzodiazepínicoSem interação

    Drug Interactions No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. (bula de Nizatidina, Interações medicamentosas)

  • Desloratadinaanti-histamínicoSem interação

    …safety profile of desloratadine. [See Clinical Pharmacology (12.3) .] 7.3 Cimetidine In controlled clinical studies co-administration of desloratadine with cimetidine, a histamine H2-receptor antagonist, resulted in increased plasma concentrations of desloratadine and 3 hydroxydesloratadine, but there were no clinically relevant changes in the safety profile… (bula de Desloratadina, Interações medicamentosas)

  • Ergotamina + cafeínaalcaloide do ergotSem interação

    Drug Interactions No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. (bula de Nizatidina, Interações medicamentosas)

  • Febuxostateinibidor da xantina oxidaseSem interação

    Drug Interactions No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. (bula de Nizatidina, Interações medicamentosas)

  • Lidocaínaanestésico localSem interação

    Drug Interactions No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. (bula de Nizatidina, Interações medicamentosas)

  • Lidocaína + epinefrinaanestésico localSem interação

    Drug Interactions No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. (bula de Nizatidina, Interações medicamentosas)

  • Lidocaína + prilocaínaanestésico localSem interação

    Drug Interactions No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. (bula de Nizatidina, Interações medicamentosas)

  • LorazepambenzodiazepínicoSem interação

    Drug Interactions No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. (bula de Nizatidina, Interações medicamentosas)

  • PentoxifilinametilxantinaSem interação

    Drug Interactions No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. (bula de Nizatidina, Interações medicamentosas)

  • Posaconazolantifúngico azólicoSem interação

    No clinically relevant effects on the pharmacokinetics of Noxafil delayed-release tablets were observed during concomitant use with antacids, H 2 -receptor antagonists and proton pump inhibitors, and metoclopramide [see Clinical Pharmacology (12.3) ] . (bula de Posaconazol, Interações medicamentosas)

  • Tadalafilainibidor da PDE5Sem interação

    H 2 Antagonists (e.g. Nizatidine) — An increase in gastric pH resulting from administration of nizatidine had no significant effect on pharmacokinetics. (bula de Tadalafila, Interações medicamentosas)

  • TeofilinametilxantinaSem interação

    Drug Interactions No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. (bula de Nizatidina, Interações medicamentosas)

  • VarfarinaanticoagulanteSem interação

    Drug Interactions No interactions have been observed between nizatidine and theophylline, chlordiazepoxide, lorazepam, lidocaine, phenytoin, and warfarin. (bula de Nizatidina, Interações medicamentosas)

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Não é aconselhamento médico. A gravidade reflete a redação da bula, não as suas circunstâncias. Um alerta “grave” pode ser rotina sob supervisão, e um “leve” pode ser importante em doses altas. Pergunte a um farmacêutico.