Interaction Checker

Interações de Sapropterina

Sapropterina (Kuvan, Javygtor) tem 15 interações documentadas nas bulas da FDA e nas fichas informativas que indexamos (graves: 0; moderadas: 15; leves: 0; casos em que uma bula relata não haver interação significativa: 0). Cada item abaixo cita a frase em que se baseia. Esta página de medicamento é um ponto de partida, não um veredito para a sua situação.

Interações segundo a bula

Interações moderadas (15)

  • Ácido fólico (folato)Vitaminas e mineraisModerada

    Inhibitors of Folate Synthesis (e.g., methotrexate, valproic acid, phenobarbital, trimethoprim) Clinical Impact In vitro and in vivo nonclinical data suggest that drugs that inhibit folate synthesis may decrease the bioavailability of endogenous BH4 by inhibiting the enzyme dihydrofolate reductase, which is involved in the recycling (regeneration) of BH4. (bula de Sapropterina, Interações medicamentosas)

  • Ácido valproicoanticonvulsivanteModerada

    Inhibitors of Folate Synthesis (e.g., methotrexate, valproic acid, phenobarbital, trimethoprim) Clinical Impact In vitro and in vivo nonclinical data suggest that drugs that inhibit folate synthesis may decrease the bioavailability of endogenous BH4 by inhibiting the enzyme dihydrofolate reductase, which is involved in the recycling (regeneration) of BH4. (bula de Sapropterina, Interações medicamentosas)

  • AmantadinaanticolinérgicoModerada

    Interaction with Levodopa : Seizures, over-stimulation or irritability may occur; monitor patients for a change in neurologic status. (bula de Sapropterina, Advertências e precauções)

  • Avanafilainibidor da PDE5Moderada

    Drugs Affecting Nitric Oxide‑Mediated Vasorelaxation (e.g., PDE-5 inhibitors) : Potential for vasorelaxation; monitor blood pressure. (bula de Sapropterina, Interações medicamentosas)

  • Carbidopa + levodopamedicamento dopaminérgicoModerada

    Interaction with Levodopa : Seizures, over-stimulation or irritability may occur; monitor patients for a change in neurologic status. (bula de Sapropterina, Advertências e precauções)

  • Carbidopa + levodopa + entacaponamedicamento dopaminérgicoModerada

    Interaction with Levodopa : Seizures, over-stimulation or irritability may occur; monitor patients for a change in neurologic status. (bula de Sapropterina, Advertências e precauções)

  • FenobarbitalbarbitúricoModerada

    Inhibitors of Folate Synthesis (e.g., methotrexate, valproic acid, phenobarbital, trimethoprim) Clinical Impact In vitro and in vivo nonclinical data suggest that drugs that inhibit folate synthesis may decrease the bioavailability of endogenous BH4 by inhibiting the enzyme dihydrofolate reductase, which is involved in the recycling (regeneration) of BH4. (bula de Sapropterina, Interações medicamentosas)

  • Fenobarbital + hiosciamina + atropina + escopolaminabarbitúricoModerada

    Inhibitors of Folate Synthesis (e.g., methotrexate, valproic acid, phenobarbital, trimethoprim) Clinical Impact In vitro and in vivo nonclinical data suggest that drugs that inhibit folate synthesis may decrease the bioavailability of endogenous BH4 by inhibiting the enzyme dihydrofolate reductase, which is involved in the recycling (regeneration) of BH4. (bula de Sapropterina, Interações medicamentosas)

  • Levodopamedicamento dopaminérgicoModerada

    Interaction with Levodopa : Seizures, over-stimulation or irritability may occur; monitor patients for a change in neurologic status. (bula de Sapropterina, Advertências e precauções)

  • MetotrexatoimunossupressorModerada

    Inhibitors of Folate Synthesis (e.g., methotrexate, valproic acid, phenobarbital, trimethoprim) Clinical Impact In vitro and in vivo nonclinical data suggest that drugs that inhibit folate synthesis may decrease the bioavailability of endogenous BH4 by inhibiting the enzyme dihydrofolate reductase, which is involved in the recycling (regeneration) of BH4. (bula de Sapropterina, Interações medicamentosas)

  • Sildenafilainibidor da PDE5Moderada

    Drugs Affecting Nitric Oxide‑Mediated Vasorelaxation (e.g., PDE-5 inhibitors) : Potential for vasorelaxation; monitor blood pressure. (bula de Sapropterina, Interações medicamentosas)

  • Sulfametoxazol + trimetoprimasulfonamidaModerada

    Inhibitors of Folate Synthesis (e.g., methotrexate, valproic acid, phenobarbital, trimethoprim) Clinical Impact In vitro and in vivo nonclinical data suggest that drugs that inhibit folate synthesis may decrease the bioavailability of endogenous BH4 by inhibiting the enzyme dihydrofolate reductase, which is involved in the recycling (regeneration) of BH4. (bula de Sapropterina, Interações medicamentosas)

  • Tadalafilainibidor da PDE5Moderada

    Drugs Affecting Nitric Oxide‑Mediated Vasorelaxation (e.g., PDE-5 inhibitors) : Potential for vasorelaxation; monitor blood pressure. (bula de Sapropterina, Interações medicamentosas)

  • TrimetoprimaantibióticoModerada

    Inhibitors of Folate Synthesis (e.g., methotrexate, valproic acid, phenobarbital, trimethoprim) Clinical Impact In vitro and in vivo nonclinical data suggest that drugs that inhibit folate synthesis may decrease the bioavailability of endogenous BH4 by inhibiting the enzyme dihydrofolate reductase, which is involved in the recycling (regeneration) of BH4. (bula de Sapropterina, Interações medicamentosas)

  • Vardenafilainibidor da PDE5Moderada

    Drugs Affecting Nitric Oxide‑Mediated Vasorelaxation (e.g., PDE-5 inhibitors) : Potential for vasorelaxation; monitor blood pressure. (bula de Sapropterina, Interações medicamentosas)

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