Interação entre Carisoprodol e Desflurano

• Additive sedative effects when used with other CNS depressants including alcohol (5.1)

Since the sedative effects of carisoprodol and other CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants) may be additive, appropriate caution should be exercised with patients who take more than one of these CNS depressants simultaneously.

CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants) - additive sedative effects ( 5.1 , 7.1 )

CNS Depressants The sedative effects of carisoprodol and other CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants) may be additive.

Therefore, caution should be exercised with patients who take more than one of these CNS depressants simultaneously.

For endotracheal intubation, do not reduce the dose of nondepolarizing muscle relaxants or succinylcholine.

During maintenance of anesthesia, the dose of nondepolarizing muscle relaxants is likely to be reduced compared to that during N2O/opioid anesthesia.

Administration of supplemental doses of muscle relaxants should be guided by the response to nerve stimulation.

DRUG INTERACTIONS No clinically significant adverse interactions with commonly used preanesthetic drugs, or drugs used during anesthesia (muscle relaxants, intravenous agents, and local anesthetic agents) were reported in clinical trials.