Interação entre Celecoxibe e Fluconazol
Celecoxibe e Fluconazol: ambas as bulas profissionais descrevem uma interação que geralmente exige monitoramento, alteração da dose ou espaçamento entre as doses.
Geralmente controlável com monitoramento ou alteração da dose. Informe ao seu farmacêutico que você toma os dois.
O que dizem as bulas da FDA
Da bula de Celecoxibe (VYSCOXA) · em vigor desde 2025-07-31
Co-administration of celecoxib with drugs that are known to inhibit CYP2C9 (e.g., fluconazole) may enhance the exposure and toxicity of celecoxib whereas co-administration with CYP2C9 inducers (e.g., rifampin) may lead to compromised efficacy of celecoxib.
A dosage adjustment may be warranted when VYSCOXA is administered with CYP2C9 inhibitors or inducers [ see Clinical Pharmacology (12.3) ].
CYP2C9 Inhibitors or inducers Clinical Impact: Celecoxib metabolism is predominantly mediated via cytochrome P450 (CYP) 2C9 in the liver.
Da bula de Fluconazol (Fluconazole) · em vigor desde 2026-04-02
Celecoxib During concomitant treatment with fluconazole (200 mg daily) and celecoxib (200 mg), the celecoxib C max and AUC increased by 68% and 134%, respectively.
Half of the celecoxib dose may be necessary when combined with fluconazole.
Non-steroidal anti-inflammatory drugs The C max and AUC of flurbiprofen were increased by 23% and 81%, respectively, when coadministered with fluconazole compared to administration of flurbiprofen alone.
Although not specifically studied, fluconazole has the potential to increase the systemic exposure of other non-steroidal anti-inflammatory drugs (NSAIDs) that are metabolized by CYP2C9 (e.g., naproxen, lornoxicam, meloxicam, diclofenac).
Frequent monitoring for adverse events and toxicity related to NSAIDs is recommended.
Toma mais do que estes dois? As interações se acumulam. Verifique sua lista inteira de uma vez; ela fica no seu navegador.
Abrir no verificadorNão é aconselhamento médico. Interaction Checker cita o texto das bulas da FDA e fichas informativas do NIH. A importância de uma interação para você depende das doses, dos horários, da função renal e hepática e de outras condições de saúde. Confirme com um farmacêutico ou com o prescritor.