Interação entre Cenobamato e Clonazepam
Cenobamato e Clonazepam: ambas as bulas profissionais descrevem uma interação que geralmente exige monitoramento, alteração da dose ou espaçamento entre as doses.
Geralmente controlável com monitoramento ou alteração da dose. Informe ao seu farmacêutico que você toma os dois.
O que dizem as bulas da FDA
Da bula de Clonazepam (Klonopin) · em vigor desde 2025-12-01
They should also be warned about the concomitant use of alcohol or other CNS-depressant drugs during Klonopin therapy (see PRECAUTIONS: Drug Interactions and PRECAUTIONS: Information for Patients ).
…Interactions The CNS-depressant action of the benzodiazepine class of drugs may be potentiated by alcohol, narcotics, barbiturates, nonbarbiturate hypnotics, antianxiety agents, the phenothiazines, thioxanthene and butyrophenone classes of antipsychotic agents, monoamine oxidase inhibitors and the tricyclic antidepressants, and by other anticonvulsant drugs.
The selective serotonin reuptake inhibitors sertraline (weak CYP3A4 inducer) and fluoxetine (CYP2D6 inhibitor), and the anti-epileptic drug felbamate (CYP2C19 inhibitor and CYP3A4 inducer) do not affect the pharmacokinetics of clonazepam.
Da bula de Cenobamato (Xcopri) · em vigor desde 2025-08-25
Concomitant use with other CNS depressants or alcohol may have additive effects.
Anyone considering prescribing XCOPRI or any other AED must balance this risk with the risk of untreated illness.
Patients should be carefully observed for signs of central nervous system (CNS) depression, such as somnolence and sedation, when XCOPRI is used with other drugs with sedative properties because of potential additive effects.
CNS Depressants and Alcohol Concomitant use of XCOPRI with other CNS depressants, including alcohol, may increase the risk of neurological adverse reactions, including sedation and somnolence [see Warnings and Precautions ( 5.5 )] .
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Abrir no verificadorNão é aconselhamento médico. Interaction Checker cita o texto das bulas da FDA e fichas informativas do NIH. A importância de uma interação para você depende das doses, dos horários, da função renal e hepática e de outras condições de saúde. Confirme com um farmacêutico ou com o prescritor.