Interação entre Sevoflurano e Tizanidina
Sevoflurano e Tizanidina: ambas as bulas profissionais descrevem uma interação que geralmente exige monitoramento, alteração da dose ou espaçamento entre as doses.
Geralmente controlável com monitoramento ou alteração da dose. Informe ao seu farmacêutico que você toma os dois.
O que dizem as bulas da FDA
Da bula de Tizanidina (Zanaflex) · em vigor desde 2026-01-02
Sedation: Zanaflex may interfere with everyday activities; sedative effects of Zanaflex, alcohol, and other central nervous system (CNS) depressants are additive ( 5.3 , 7.4 )
The CNS depressant effects of Zanaflex with alcohol and other CNS depressants (e.g., benzodiazepines, opioids, tricyclic antidepressants) may be additive [see Drug Interactions ( 7.4 )] .
Monitor patients who take Zanaflex with another CNS depressant for symptoms of excess sedation.
Alcohol and Other CNS Depressants Alcohol increases the exposure of tizanidine after administration of Zanaflex.
Concomitant use of Zanaflex with CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants) may cause additive CNS depressant effects, including sedation.
Da bula de Sevoflurano (Ultane) · em vigor desde 2025-01-13
Neuromuscular Blocking Agents As is the case with other volatile anesthetics, sevoflurane increases both the intensity and duration of neuromuscular blockade induced by nondepolarizing muscle relaxants.
Therefore, during sevoflurane anesthesia, the dosage adjustments for these muscle relaxants are similar to those required with isoflurane.
In the absence of specific guidelines: For endotracheal intubation, do not reduce the dose of nondepolarizing muscle relaxants.
During maintenance of anesthesia, the required dose of nondepolarizing muscle relaxants is likely to be reduced compared to that during N 2 O/opioid anesthesia.
Administration of supplemental doses of muscle relaxants should be guided by the response to nerve stimulation.
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Abrir no verificadorNão é aconselhamento médico. Interaction Checker cita o texto das bulas da FDA e fichas informativas do NIH. A importância de uma interação para você depende das doses, dos horários, da função renal e hepática e de outras condições de saúde. Confirme com um farmacêutico ou com o prescritor.