Interaction Checker

Vitamin E interactions

High-dose vitamin E can inhibit platelet aggregation and add to the bleeding risk of blood thinners.

Vitamin E has 27 documented interactions across the FDA labels and fact sheets we index: 0 major, 24 moderate, 3 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This vitamin and mineral page is a starting point, not a verdict for your situation.

Interactions from the label

Moderate interactions (24)

  • ApixabananticoagulantModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • ArgatrobananticoagulantModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • AspirinNSAIDModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • Aspirin and dipyridamoleantiplatelet agentModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • BivalirudinanticoagulantModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • Butalbital, aspirin, and caffeinebarbiturateModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • Butalbital, aspirin, caffeine, and codeinebarbiturateModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • Cangrelorantiplatelet agentModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • Cilostazolantiplatelet agentModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • Clopidogrelantiplatelet agentModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • DabigatrananticoagulantModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • Dipyridamoleantiplatelet agentModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • EdoxabananticoagulantModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • EnoxaparinanticoagulantModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • Eptifibatideantiplatelet agentModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • FondaparinuxanticoagulantModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • HeparinanticoagulantModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • LomitapideModerate

    In this trial, the median levels of serum vitamin E, ALA, linoleic acid, EPA, DHA, and arachidonic acid decreased from baseline to Week 26 but remained above the lower limit of the reference range. (Lomitapide label, Warnings and precautions)

  • Orphenadrine, aspirin, and caffeinemuscle relaxantModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • Prasugrelantiplatelet agentModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • RivaroxabananticoagulantModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • Ticagrelorantiplatelet agentModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • Tirofibanantiplatelet agentModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

  • WarfarinanticoagulantModerate

    Vitamin E can inhibit platelet aggregation and vitamin K-dependent clotting, increasing bleeding risk with anticoagulant and antiplatelet drugs. (NIH Office of Dietary Supplements, Vitamin E)

Minor mentions (3)

  • NiacinMinor

    Antioxidant combinations including vitamin E blunted the HDL-raising effect of simvastatin plus niacin in a clinical study. (NIH Office of Dietary Supplements, Vitamin E)

  • OrlistatMinor

    ORLISTAT inhibited absorption of a vitamin E acetate supplement. (Orlistat label, Drug interactions)

  • SimvastatinstatinMinor

    Antioxidant combinations including vitamin E blunted the HDL-raising effect of simvastatin plus niacin in a clinical study. (NIH Office of Dietary Supplements, Vitamin E)

Check Vitamin E against everything you take. Add your full list; every pair is checked at once.

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.