Interaction Checker

Zinc interactions

Zinc binds some antibiotics in the gut, and a few drugs increase zinc loss.

Zinc has 32 documented interactions across the FDA labels and fact sheets we index: 0 major, 10 moderate, 22 minor, and 0 where a label reports no significant interaction. Each entry below quotes the sentence behind it. This vitamin and mineral page is a starting point, not a verdict for your situation.

Interactions from the label

Moderate interactions (10)

  • Bismuth subcitrate, metronidazole, and tetracyclineantibioticModerate

    Zinc reduces absorption of quinolone and tetracycline antibiotics; take the antibiotic at least two hours before or four to six hours after zinc. (NIH Office of Dietary Supplements, Zinc)

  • CiprofloxacinfluoroquinoloneModerate

    Zinc reduces absorption of quinolone and tetracycline antibiotics; take the antibiotic at least two hours before or four to six hours after zinc. (NIH Office of Dietary Supplements, Zinc)

  • Demeclocyclinetetracycline antibioticModerate

    Zinc reduces absorption of quinolone and tetracycline antibiotics; take the antibiotic at least two hours before or four to six hours after zinc. (NIH Office of Dietary Supplements, Zinc)

  • Doxycyclinetetracycline antibioticModerate

    Zinc reduces absorption of quinolone and tetracycline antibiotics; take the antibiotic at least two hours before or four to six hours after zinc. (NIH Office of Dietary Supplements, Zinc)

  • LevofloxacinfluoroquinoloneModerate

    Zinc reduces absorption of quinolone and tetracycline antibiotics; take the antibiotic at least two hours before or four to six hours after zinc. (NIH Office of Dietary Supplements, Zinc)

  • Minocyclinetetracycline antibioticModerate

    Zinc reduces absorption of quinolone and tetracycline antibiotics; take the antibiotic at least two hours before or four to six hours after zinc. (NIH Office of Dietary Supplements, Zinc)

  • MoxifloxacinfluoroquinoloneModerate

    Zinc reduces absorption of quinolone and tetracycline antibiotics; take the antibiotic at least two hours before or four to six hours after zinc. (NIH Office of Dietary Supplements, Zinc)

  • OfloxacinfluoroquinoloneModerate

    Zinc reduces absorption of quinolone and tetracycline antibiotics; take the antibiotic at least two hours before or four to six hours after zinc. (NIH Office of Dietary Supplements, Zinc)

  • Tetracyclinetetracycline antibioticModerate

    Zinc reduces absorption of quinolone and tetracycline antibiotics; take the antibiotic at least two hours before or four to six hours after zinc. (NIH Office of Dietary Supplements, Zinc)

  • Tigecyclinetetracycline antibioticModerate

    Zinc reduces absorption of quinolone and tetracycline antibiotics; take the antibiotic at least two hours before or four to six hours after zinc. (NIH Office of Dietary Supplements, Zinc)

Minor mentions (22)

  • Atenolol and chlorthalidonebeta blockerMinor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Benazepril and hydrochlorothiazideACE inhibitorMinor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Bisoprolol and hydrochlorothiazidebeta blockerMinor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Candesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Chlorothiazidethiazide diureticMinor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Chlorthalidonethiazide diureticMinor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Enalapril and hydrochlorothiazideACE inhibitorMinor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Fosinopril and hydrochlorothiazideACE inhibitorMinor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Hydrochlorothiazidethiazide diureticMinor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Indapamidethiazide diureticMinor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Irbesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Lisinopril and hydrochlorothiazideACE inhibitorMinor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Losartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Metolazonethiazide diureticMinor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Metoprolol and hydrochlorothiazidebeta blockerMinor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Olmesartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Olmesartan, amlodipine, and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Quinapril and hydrochlorothiazideACE inhibitorMinor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Spironolactone and hydrochlorothiazidealdosterone antagonistMinor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Telmisartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Triamterene and hydrochlorothiazidepotassium-sparing diureticMinor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

  • Valsartan and hydrochlorothiazideangiotensin II receptor blocker (ARB)Minor

    Thiazide diuretics increase zinc loss in urine with long-term use. (NIH Office of Dietary Supplements, Zinc)

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Not medical advice. Severity reflects the label's wording, not your circumstances. A "major" flag can be routine under supervision and a "minor" one can matter at high doses. Ask a pharmacist.