Azelastin ve flutikazon ve Droperidol etkileşimi

• Avoid concurrent use of alcohol or other central nervous system (CNS) depressants with azelastine hydrochloride and fluticasone propionate nasal spray because further decreased alertness and impairment of CNS performance may occur.

Concurrent use of azelastine hydrochloride and fluticasone propionate nasal spray with alcohol or other central nervous system depressants should be avoided because additional reductions in alertness and additional impairment of central nervous system performance may occur [see Drug Interactions ( 7.1 )].

Possible pharmacodynamic interactions can occur between droperidol and potentially arrhythmogenic agents such as class I or III antiarrhythmics, antihistamines that prolong the QT interval, antimalarials, calcium channel blockers, neuroleptics that prolong the QT interval, and antidepressants.

Following the administration of droperidol, the dose of other CNS depressant drugs should be reduced.

As with other CNS depressant drugs, patients who have received droperidol should have appropriate surveillance.

These would include diuretics, laxatives and supraphysiological use of steroid hormones with mineralocorticoid potential.