Siprofloksasin ve Lantan etkileşimi

…Ciprofloxacin Antacids, Sucralfate, Multivitamins and Other Products Containing Multivalent Cations (magnesium/aluminum antacids; polymeric phosphate binders (for example, sevelamer, lanthanum carbonate); sucralfate; Videx ® (didanosine) chewable/buffered tablets or pediatric powder; other highly buffered drugs; or products containing calcium, iron, or zinc and…

The bioavailability of oral ciprofloxacin was decreased by approximately 50% when taken with LANTHANUM CARBONATE in a single-dose study in healthy volunteers.

Examples of relevant classes of compounds where antacids have been demonstrated to reduce bioavailability include antibiotics (such as quinolones, ampicillin, and tetracyclines), thyroid hormones, ACE inhibitors, statin lipid regulators, and anti-malarials.

Quinolone Antibiotics Co-administration of LANTHANUM CARBONATE with quinolone antibiotics may reduce the extent of their absorption.

When oral quinolones are given for short courses, consider eliminating the doses of LANTHANUM CARBONATE that would normally be scheduled near the time of quinolone intake to improve quinolone absorption [see Clinical Pharmacology (12.3) ] .

Oral quinolone antibiotics must be taken at least 1 hour before or 4 hours after LANTHANUM CARBONATE.