التداخل بين الكحول وديسلفيرام

WARNING Disulfiram should never be administered to a patient when he is in a state of alcohol intoxication, or without his full knowledge.

CONTRAINDICATIONS Patients who are receiving or have recently received metronidazole, paraldehyde, alcohol, or alcohol-containing preparations, e.g., cough syrups, tonics and the like, should not be given disulfiram.

He should be warned to avoid alcohol in disguised forms, i.e., in sauces, vinegars, cough mixtures, and even in aftershave lotions and back rubs.

The Disulfiram-Alcohol Reaction Disulfiram plus alcohol, even small amounts, produce flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, marked uneasiness, weakness, vertigo, blurred vision, and confusion.

Mild reactions may occur in the sensitive individual when the blood alcohol concentration is increased to as little as 5 mg to 10 mg per 100 mL.

قد يسبب تفاعلًا شبيهًا بتفاعل ديسلفيرام: احمرار الوجه والغثيان والقيء وتسارع ضربات القلب والصداع.

النص الأصلي للنشرة (بالإنجليزية) Can cause a disulfiram-like reaction: flushing, nausea, vomiting, rapid heartbeat, and headache.