التداخل بين أميلوريد وليثيوم

Amiloride may be considered as a therapeutic agent for lithium-induced nephrogenic diabetes insipidus.

• Diuretics, NSAID, renin-angiotensin system antagonists, or metronidazole may increase lithium serum concentrations.

Drugs Having Clinically Important Interactions with Lithium Table 4: Clinically Important Drug Interactions with Lithium Diuretics Clinical Impact: Diuretic-induced sodium loss may reduce lithium clearance and increase serum lithium concentrations .

Discontinue lithium or treat with amiloride as a therapeutic agent ( 5.2 ).

(See WARNINGS .) Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity.

Read circulars for lithium preparations before use of such concomitant therapy.