التداخل بين بيسوبرولول وهيدروكلوروثيازيد وغليبنكلاميد

…Interactions The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, ACE inhibitors, disopyramide, fluoxetine, clarithromycin, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents.

These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid.

Beta-blockers may further increase the risk of severe hypoglycemia when used concurrently with sulfonylureas.

The concomitant use of beta-blockers with sulfonylureas may increase the risk of severe hypoglycemia (see WARNINGS – Hypoglycemia ).

Antidiabetic drugs (oral agents and insulin) - dosage adjustment of the antidiabetic drug may be required.