Bisoprolol and hydrochlorothiazide and Glyburide interaction
Bisoprolol and hydrochlorothiazide and Glyburide: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Bisoprolol and hydrochlorothiazide (bisoprolol fumarate and hydrochlorothiazide) label · effective 2026-08-11
Beta-blockers may further increase the risk of severe hypoglycemia when used concurrently with sulfonylureas.
The concomitant use of beta-blockers with sulfonylureas may increase the risk of severe hypoglycemia (see WARNINGS – Hypoglycemia ).
Antidiabetic drugs (oral agents and insulin) - dosage adjustment of the antidiabetic drug may be required.
From the Glyburide label · effective 2021-07-01
…Interactions The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, ACE inhibitors, disopyramide, fluoxetine, clarithromycin, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents.
These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.