التداخل بين كلوروكين وهيدروكسي كلوروكين

Therefore, PLAQUENIL is not recommended in patients taking other drugs that have the potential to prolong the QT interval.

Cimetidine Concomitant use of cimetidine resulted in a 2-fold increase of exposure of chloroquine, which is structurally related to hydroxychloroquine.

Praziquantel Chloroquine has been reported to reduce the bioavailability of praziquantel.

Antacids and kaolin Antacids and kaolin can reduce absorption of chloroquine; an interval of at least 4 hours between intake of these agents and chloroquine should be observed.

Ampicillin In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin.

Patients infected with a resistant strain of plasmodia as shown by the fact that normally adequate doses have failed to prevent or cure clinical malaria or parasitemia should be treated with another form of antimalarial therapy.

WARNINGS Chloroquine-Resistant Malaria Chloroquine phosphate tablets are not effective against chloroquine- or hydroxychloroquine-resistant strains of Plasmodium species (see CLINICAL PHARMACOLOGY , Microbiology ).