التداخل بين ديفالبروكس (فالبروات) وحمض الفوليك (الفولات)

Evidence suggests that folic acid supplementation prior to conception and during the first trimester of pregnancy decreases the risk for congenital neural tube defects in the general population [see Use in Specific Populations ( 8.1 )] .

It is not known whether the risk of neural tube defects or decreased IQ in the offspring of women receiving valproate is reduced by folic acid supplementation.

Dietary folic acid supplementation both prior to conception and during pregnancy should be routinely recommended for women of childbearing potential using valproate.

هذه الأدوية المضادة للصرع تخفض مستويات الفولات، ومكملات حمض الفوليك قد تخفض بدورها مستويات الدواء في الدم.

النص الأصلي للنشرة (بالإنجليزية) These antiepileptic drugs lower folate levels, and folic acid supplements can in turn lower blood levels of the drug.