تداخلات حمض الفوليك (الفولات)

Use of the drug is also contraindicated in patients with documented megaloblastic anemia due to folate deficiency. (نشرة بيريميثامين، موانع الاستعمال)

CONTRAINDICATIONS Trimethoprim is contraindicated in individuals hypersensitive to trimethoprim and in those with documented megaloblastic anemia due to folate deficiency. (نشرة تريميثوبريم، موانع الاستعمال)

CONTRAINDICATIONS Sulfamethoxazole and trimethoprim is contraindicated in patients with a known hypersensitivity to trimethoprim or sulfonamides, in patients with a history of drug-induced immune thrombocytopenia with use of trimethoprim and/or sulfonamides, and in patients with documented megaloblastic anemia due to folate deficiency. (نشرة سلفاميثوكسازول وتريميثوبريم، موانع الاستعمال)

Effects of Other Drugs on SEPHIENCE Avoid concomitant use of drugs known to inhibit folate synthesis dihydrofolate reductase (DHFR) (e.g., trimethoprim, methotrexate, trimetrexate, pemetrexed, pralatrexate, raltitrexed, and piritrexim) while taking SEPHIENCE. (نشرة سيبيابترين، التداخلات الدوائية)

…Phenytoin and antacids should not be taken at the same time of day Antineoplastic agents (usually in combination) Bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate Antiviral agents Fosamprenavir, nelfinavir, ritonavir Antiepileptic drugs Carbamazepine, vigabatrin Other Chronic alcohol abuse, diazepam, diazoxide, folic acid, reserpine, rifampin, St. (نشرة فينيتوين، التداخلات الدوائية)

KHAPZORY is contraindicated in patients who have had severe hypersensitivity to leucovorin products, folic acid, or folinic acid [see Adverse Reactions ( 6.2 )] . (نشرة ليفوليوكوفورين، موانع الاستعمال)

VYKOURA is contraindicated in patients who have had a severe hypersensitivity reaction to leucovorin (folinic acid), levoleucovorin, or folic acid [see Warnings and Precautions (5.1) ]. (نشرة ليوكوفورين، موانع الاستعمال)

Acetazolamide may increase the effects of other folic acid antagonists. (نشرة أسيتازولاميد، التداخلات الدوائية)

…proteins may be elevated in the serum. d) Sex-steroid binding globulins are increased and result in elevated levels of total circulating sex steroids and corticoids; however, free or biologically active levels remain unchanged. e) Triglycerides and phospholipids may be increased. f) Glucose tolerance may be decreased. g) Serum folate levels may be depressed. (نشرة إيثينوديول ثنائي الأسيتات وإيثينيل إستراديول، الاحتياطات)

Administer vitamin B 12 and instruct patients to take folic acid to reduce the risk of treatment-related myelosuppression [see Dosage and Administration ( 2.1 )]. (نشرة برالاتريكسات، التحذيرات والاحتياطات)

هذه الأدوية المضادة للصرع تخفض مستويات الفولات، ومكملات حمض الفوليك قد تخفض بدورها مستويات الدواء في الدم. (NIH Office of Dietary Supplements, Folate)

Because trimethoprim may interfere with folic acid metabolism, trimethoprim should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. (نشرة بوليميكسين ب وتريميثوبريم للعين، الاحتياطات)

Initiate supplementation with oral folic acid and intramuscular vitamin B 12 to reduce the severity of hematologic and gastrointestinal toxicity of PEMFEXY. (نشرة بيميتريكسيد، التحذيرات والاحتياطات)

Evidence suggests that folic acid supplementation prior to conception and during the first trimester of pregnancy decreases the risk for congenital neural tube defects in the general population . (نشرة حمض الفالبرويك، التحذيرات والاحتياطات)

Folic acid antagonists have similar effects and may increase the incidence of hematologic reactions; if co-administered with dapsone the patient should be monitored more frequently. (نشرة دابسون، التحذيرات)

Evidence suggests that folic acid supplementation prior to conception and during the first trimester of pregnancy decreases the risk for congenital neural tube defects in the general population [see Use in Specific Populations ( 8.1 )] . (نشرة ديفالبروكس (فالبروات)، التحذيرات والاحتياطات)

Inhibitors of Folate Synthesis (e.g., methotrexate, valproic acid, phenobarbital, trimethoprim) Clinical Impact In vitro and in vivo nonclinical data suggest that drugs that inhibit folate synthesis may decrease the bioavailability of endogenous BH4 by inhibiting the enzyme dihydrofolate reductase, which is involved in the recycling (regeneration) of BH4. (نشرة سابروبترين، التداخلات الدوائية)

Drug Interactions: Reduced absorption of folic acid and digoxin have been reported when those agents were administered concomitantly with sulfasalazine. (نشرة سلفاسالازين، التداخلات الدوائية)

Reductions in Vitamins D, E, K (clotting factors) and Folic Acid Levels In preclinical studies in rats and dogs, sevelamer hydrochloride, which contains the same active moiety as sevelamer carbonate, reduced vitamins D, E, and K (coagulation parameters) and folic acid levels at doses of 6–10 times the recommended human dose. (نشرة سيفيلامير، التحذيرات والاحتياطات)

…trazodone, warfarin Drugs that may decrease phenytoin serum levels Antineoplastic agents usually in combination Bleomycin, carboplatin, cisplatin, doxorubicin, methotrexate Antiviral agents Fosamprenavir, nelfinavir, ritonavir Antiepileptic drugs Carbamazepine, vigabatrin Other Chronic alcohol abuse, diazepam, diazoxide, folic acid, reserpine, rifampin, St. (نشرة فوسفينيتوين، التداخلات الدوائية)

هذه الأدوية المضادة للصرع تخفض مستويات الفولات، ومكملات حمض الفوليك قد تخفض بدورها مستويات الدواء في الدم. (NIH Office of Dietary Supplements, Folate)

Leucovorin The concentration of fluorouracil is increased and its toxicity may be enhanced by leucovorin, folic acid, or folate analog products. (نشرة كابيسيتابين، التداخلات الدوائية)

هذه الأدوية المضادة للصرع تخفض مستويات الفولات، ومكملات حمض الفوليك قد تخفض بدورها مستويات الدواء في الدم. (NIH Office of Dietary Supplements, Folate)

Nitrous Oxide The use of nitrous oxide anesthesia potentiates the effect of methotrexate on folate-dependent metabolic pathways, resulting in the potential for increase toxicity. (نشرة ميثوتريكسات، التداخلات الدوائية)

In RA, concomitant medications besides MTX were nonsteroidal anti-inflammatory agents (NSAIDs), folic acid, corticosteroids and/or narcotics. (نشرة إنفليكسيماب، التداخلات الدوائية)

Drug Interactions There was no evidence of drug interactions in clinical studies in which dobutamine was administered concurrently with other drugs, including digitalis preparations, furosemide, spironolactone, lidocaine, glyceryl trinitrate, isosorbide dinitrate, morphine, atropine, heparin, protamine, potassium chloride, folic acid, and acetaminophen. (نشرة دوبوتامين، التداخلات الدوائية)

Serum folate levels may be depressed by oral contraceptive therapy. (نشرة ديسوجيستريل وإيثينيل إستراديول، الاحتياطات)

Interactions with Laboratory Tests Therapeutic concentrations of rifampin have been shown to inhibit standard microbiological assays for serum folate and Vitamin B 12 . (نشرة ريفابنتين، التداخلات الدوائية)

The morphologic change resembles pernicious anemia, but is not related to vitamin B12 or folic acid deficiency. (نشرة هيدروكسي يوريا، التحذيرات والاحتياطات)