التداخل بين دوكسازوسين ونيفيديبين

In the presence of doxazosin, AUC and C max of nifedipine were increased by factors of 1.13 and 1.23, respectively.

Blood pressure should be monitored when doxazosin is co-administered with nifedipine, and dose reduction of nifedipine considered.

Central Alpha1-Blockers Doxazosin: Healthy volunteers participating in a multiple dose doxazosin-nifedipine interaction study received 2 mg doxazosin q.d. alone or combined with 20 mg nifedipine ER b.i.d. Co-administration of nifedipine resulted in a decrease in AUC and C max of doxazosin to 83% and 86% of the values in the absence of nifedipine, respectively.

Compared to nifedipine monotherapy, blood pressure was lower in the presence of doxazosin.