التداخل بين الجريب فروت ونيفيديبين

Grapefruit juice should be avoided by patients on nifedipine.

…as ketoconazole, fluconazole, itraconazole, clarithromycin, erythromycin (Azithromycin, although structurally related to the class of macrolide antibiotic is void of clinically relevant CYP3A4 inhibition), grapefruit, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir, and ritonavir may result in increased exposure to nifedipine when co-administered.

Dietary Supplements Grapefruit Juice: In healthy volunteers, a single dose co-administration of 250 mL double strength grapefruit juice with 10 mg nifedipine increased AUC and C max by factors of 1.35 and 1.13, respectively.

Ingestion of repeated doses of grapefruit juice (5 × 200 mL in 12 hours) after administration of 20 mg nifedipine ER increased AUC and C max of nifedipine by a factor of 2.

The intake of grapefruit juice should be stopped at least 3 days prior to initiating patients on nifedipine.

عصير الجريب فروت قد يرفع مستويات بعض حاصرات قنوات الكالسيوم المستعملة لضغط الدم في الدم، مما قد يسبب انخفاضًا مفرطًا في ضغط الدم.

النص الأصلي للنشرة (بالإنجليزية) Grapefruit juice can raise blood levels of some calcium channel blockers used for blood pressure, which may cause excessive lowering of blood pressure.