التداخل بين فيلوديبين والجريب فروت

Coadministration of CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin, grapefruit juice, cimetidine) with felodipine may lead to several-fold increases in the plasma levels of felodipine, either due to an increase in bioavailability or due to a decrease in metabolism.

Grapefruit juice - Coadministration of felodipine with grapefruit juice resulted in more than 2-fold increase in the AUC and C max , but no prolongation in the half-life of felodipine.

عصير الجريب فروت قد يرفع مستويات بعض حاصرات قنوات الكالسيوم المستعملة لضغط الدم في الدم، مما قد يسبب انخفاضًا مفرطًا في ضغط الدم.

النص الأصلي للنشرة (بالإنجليزية) Grapefruit juice can raise blood levels of some calcium channel blockers used for blood pressure, which may cause excessive lowering of blood pressure.