التداخل بين فلوكونازول وغليبيزيد

Oral hypoglycemics Clinically significant hypoglycemia may be precipitated by the use of fluconazole with oral hypoglycemic agents; one fatality has been reported from hypoglycemia in association with combined fluconazole and glyburide use.

Fluconazole reduces the metabolism of tolbutamide, glyburide, and glipizide and increases the plasma concentration of these agents.

When fluconazole is used concomitantly with these or other sulfonylurea oral hypoglycemic agents, blood glucose concentrations should be carefully monitored and the dose of the sulfonylurea should be adjusted as necessary.

Severe hypoglycemia can occur when GLUCOTROL and oral miconazole are used concomitantly ( 7.2 , 12.3 ). ▪ Fluconazole: Monitor patients closely.

An increase in GLUCOTROL AUC was seen after fluconazole administration ( 7.3 , 12.3 ). ▪ Colesevelam: GLUCOTROL XL should be administered at least 4 hours prior to colesevelam ( 7.4 , 12.3 ).

Fluconazole Monitor patients closely for hypoglycemia when Glucotrol XL is co-administered with fluconazole.

Concomitant treatment with fluconazole increases plasma concentrations of glipizide, which may lead to hypoglycemia [see Clinical Pharmacology (12.3) ] .