التداخل بين ليفونورجيستريل ونوريثيستيرون

…Precautions ( 5.4 )] • Postpartum endometritis or infected abortion in the past 3 months • Known or suspected uterine or cervical malignancy • Known or suspected breast cancer or other progestin-sensitive cancer, now or in the past • Uterine bleeding of unknown etiology • Untreated acute cervicitis or vaginitis, including bacterial vaginosis or other lower genital…

• Known or suspected breast cancer or other progestin-sensitive cancer ( 4 )

• Uterine perforation may occur and may reduce contraceptive effectiveness or require surgery.

In addition, perforation may reduce contraceptive efficacy and result in pregnancy.

• Partial or complete expulsion may occur, which can be unnoticed, leading to loss of contraceptive efficacy.

• Effects of Other Drugs on Hormonal Contraceptives Substances decreasing the systemic concentrations of hormonal contraceptives (HCs) and potentially diminishing the efficacy of HCs: Drugs or herbal products that induce certain enzymes, including cytochrome P450 3A4 (CYP3A4), may decrease the systemic concentrations of HCs and potentially diminish the effectiveness…