Levonorgestrel and Norethindrone interaction
Levonorgestrel and Norethindrone: the Levonorgestrel prescribing label flags this combination with the strongest language, such as a contraindication, a boxed warning, or an instruction to avoid it.
Do not combine without a prescriber's guidance. The label language below is the strongest FDA uses.
What the FDA labels say
From the Levonorgestrel (Skyla) label · effective 2026-03-04
…Precautions ( 5.4 )] • Postpartum endometritis or infected abortion in the past 3 months • Known or suspected uterine or cervical malignancy • Known or suspected breast cancer or other progestin-sensitive cancer, now or in the past • Uterine bleeding of unknown etiology • Untreated acute cervicitis or vaginitis, including bacterial vaginosis or other lower genital…
• Known or suspected breast cancer or other progestin-sensitive cancer ( 4 )
• Uterine perforation may occur and may reduce contraceptive effectiveness or require surgery.
In addition, perforation may reduce contraceptive efficacy and result in pregnancy.
• Partial or complete expulsion may occur, which can be unnoticed, leading to loss of contraceptive efficacy.
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.