التداخل بين ميثوتريكسات وبروبينيسيد

Probenecid Probenecid may reduce renal elimination of methotrexate.

Probenecid increases plasma concentrations of methotrexate in both animals and humans.

In animal studies, increased methotrexate toxicity has been reported.

If probenecid is given with methotrexate, the dosage of methotrexate should be reduced and serum levels may need to be monitored.

In animals and in humans, probenecid has been reported to increase plasma concentrations of methotrexate (see WARNINGS ).