Methotrexate and Probenecid interaction
Methotrexate and Probenecid: both prescribing labels describe an interaction that usually calls for monitoring, a dose change, or spacing the doses.
Usually manageable with monitoring or a dose change. Tell your pharmacist you take both.
What the FDA labels say
From the Methotrexate (Xatmep) label · effective 2026-05-28
Probenecid Probenecid may reduce renal elimination of methotrexate.
From the Probenecid label · effective 2026-04-29
Probenecid increases plasma concentrations of methotrexate in both animals and humans.
In animal studies, increased methotrexate toxicity has been reported.
If probenecid is given with methotrexate, the dosage of methotrexate should be reduced and serum levels may need to be monitored.
In animals and in humans, probenecid has been reported to increase plasma concentrations of methotrexate (see WARNINGS ).
Taking more than these two? Interactions stack. Check your whole list at once; it stays in your browser.
Open in the checkerNot medical advice. Interaction Checker quotes FDA label text and NIH fact sheets. Whether an interaction matters for you depends on doses, timing, kidney and liver function, and other conditions. Confirm with a pharmacist or prescriber.