التداخل بين ميتولازون وفينترمين وتوبيرامات

Sympathomimetics Metolazone may decrease arterial responsiveness to norepinephrine, but this diminution is not sufficient to preclude effectiveness of the pressor agent for therapeutic use.

In addition, when phentermine and topiramate extended-release capsules are used in conjunction with nonpotassium sparing diuretics this may further potentiate potassium-wasting.

…phentermine and topiramate extended-release capsules dosage reduction or discontinuation if cognitive dysfunction persists [see Warnings and Precautions (5.5) ] Non-Potassium Sparing Diuretics Clinical Impact Concurrent use of phentermine and topiramate extended-release capsules with non-potassium sparing diuretics may potentiate the potassium-wasting action of…

Intervention When phentermine and topiramate extended-release capsules are used concomitantly with non-potassium-sparing diuretics, measure potassium before and during phentermine and topiramate extended-release capsules treatment [see Warnings and Precautions (5.12) and Clinical Pharmacology (12.3) ] .

Non-potassium Sparing Diuretics : May potentiate hypokalemia.